Results 11 to 20 of about 63,187 (253)

Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDL [PDF]

Cardiovascular Research, 2003
Objectives: The molecular mechanisms underlying the relationship between elevated plasma concentrations of triglyceride-rich lipoproteins and coronary artery disease remain uncertain.
A.L. Catapano, A. Pirillo, P. Eriksson, G.D. Norata, E. Callegari, A. Hamsten   +5 more
core   +4 more sources

Determinants of VLDL-triglycerides production.

Current Opinion in Lipidology, 2016
PURPOSE OF REVIEW: Plasma free fatty acids (FFA) are major substrates for hepatic VLDL-triglycerides (VLDL-TG) production. In addition, it is a common belief that VLDL-TG production is a substrate driven process primarily determined by systemic FFA ...
Nielsen, Søren, Karpe, Fredrik
core   +5 more sources

Intracellular Trafficking and Secretion of VLDL [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density ...
Tiwari, Samata, Siddiqi, Shadab A.
core   +4 more sources

Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2 [PDF]

Journal of Lipid Research, 2005
In this study, we tested the hypothesis that two separate pathways, the two-step process and an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different lipoproteins.
Borén, Jan,, Stillemark-Billton, Pia,, Beck, Caroline,, Olofsson, Sven-Olof,   +3 more
core   +4 more sources

Decreases in the serum VLDL-TG/non-VLDL-TG ratio from early stages of chronic hepatitis C: alterations in TG-rich lipoprotein levels. [PDF]

PLoS ONE, 2011
BACKGROUND: The liver secretes very-low-density lipoproteins (VLDLs) and plays a key role in lipid metabolism. Plasma total triglyceride (TG) level variations have been studied in patients with hepatitis C virus (HCV)-related chronic hepatitis (CH-C ...
Motoi Nishimura, Haruna Yamamoto, Toshihiko Yoshida, Masanori Seimiya, Yuji Sawabe, Kazuyuki Matsushita, Hiroshi Umemura, Kazuyuki Sogawa, Hirotaka Takizawa, Osamu Yokosuka, Fumio Nomura   +10 more
doaj   +2 more sources

Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer [PDF]

Journal of Lipid Research, 2006
There has been more interest in VLDL-triglyceride (TG) kinetics during the last decade. Unfortunately, robust measurement methods are elaborate and not readily available.
Lars C. Gormsen, Michael D. Jensen, Søren Nielsen   +2 more
doaj   +5 more sources

Progression of Chronic Kidney Disease Affects HDL Impact on Lipoprotein Lipase (LPL)-Mediated VLDL Lipolysis Efficiency

Kidney & Blood Pressure Research, 2018
Background/Aims: Hypertriglyceridaemia (HTG) and reduction and dysfunction of high density lipoprotein (HDL) are common lipid disturbances in chronic kidney disease (CKD). HTG in CKD is caused mainly by the decreased efficiency of lipoprotein lipase (LPL)
Agnieska Ćwiklińska, Monika Cackowska, Ewa Wieczorek, Ewa Król, Robert Kowalski, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwińska, Kamil Dąbkowski, Justyna Zielińska, Alicja Dębska-Ślizień, Maciej Jankowski   +11 more
doaj   +2 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source