Results 21 to 30 of about 66,180 (284)
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince+30 more
wiley +1 more source
VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation [PDF]
Our previous work indicated that apolipoprotein (apo) E4 assumes a more expanded conformation in the postprandial period. The postprandial state is characterized by increased VLDL lipolysis.
Sarada D. Tetali+9 more
doaj +4 more sources
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol+22 more
wiley +1 more source
Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2 [PDF]
In this study, we tested the hypothesis that two separate pathways, the two-step process and an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different lipoproteins. Expression of apoB-100 and C-terminally truncated forms of apoB-100 in McA-RH7777 cells demonstrated that VLDL particles can be assembled by apoB size-dependent ...
Caroline Beck+3 more
openaire +4 more sources
Background: Hepatic de novo lipogenesis (DNL) is ideally measured in very low-density lipoprotein (VLDL)-triacylglycerol (TAG). In the fasting state, the majority of plasma TAG typically represents VLDL-TAG; however, the merits of measuring DNL in total ...
Leanne Hodson+6 more
doaj +1 more source
Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis.
Deciphering novel pathways regulating liver lipid content has profound implications for understanding the pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Ji-Yeon Shin+9 more
semanticscholar +1 more source
ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance [PDF]
Apolipoprotein (apo)A-II is a major high density lipoprotein (HDL) protein; however, its role in lipoprotein metabolism is largely unknown. Transgenic (Tg) mice that overexpress human apoA-II present functional lecithin: cholesterol acyltransferase deficiency, HDL deficiency, hypertriglyceridemia and, when fed an atherogenic diet, increased non-HDL ...
Joan Carles Escolà‐Gil+5 more
openalex +5 more sources
Dysfunctional VLDL metabolism in MASLD [PDF]
AbstractLipidomics has unveiled the intricate human lipidome, emphasizing the extensive diversity within lipid classes in mammalian tissues critical for cellular functions. This diversity poses a challenge in maintaining a delicate balance between adaptability to recurring physiological changes and overall stability.
Urko M. Marigorta+3 more
openaire +4 more sources
The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with ...
P. Dlugosz, J. Nimpf
semanticscholar +1 more source
Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Dietary interventions based on protein restriction (PR) reduce circulating triglycerides (TGs), but underlying mechanisms and clinical relevance remain unclear.
J. H. Treviño-Villarreal+25 more
semanticscholar +1 more source