Results 21 to 30 of about 66,180 (284)

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

open access: yesHepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince   +30 more
wiley   +1 more source

VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation [PDF]

open access: yesJournal of Lipid Research, 2010
Our previous work indicated that apolipoprotein (apo) E4 assumes a more expanded conformation in the postprandial period. The postprandial state is characterized by increased VLDL lipolysis.
Sarada D. Tetali   +9 more
doaj   +4 more sources

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

open access: yesHepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol   +22 more
wiley   +1 more source

Relation of the size and intracellular sorting of apoB to the formation of VLDL 1 and VLDL 2 [PDF]

open access: yesJournal of Lipid Research, 2005
In this study, we tested the hypothesis that two separate pathways, the two-step process and an apolipoprotein B (apoB) size-dependent lipidation process, give rise to different lipoproteins. Expression of apoB-100 and C-terminally truncated forms of apoB-100 in McA-RH7777 cells demonstrated that VLDL particles can be assembled by apoB size-dependent ...
Caroline Beck   +3 more
openaire   +4 more sources

Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol

open access: yesUpsala Journal of Medical Sciences, 2020
Background: Hepatic de novo lipogenesis (DNL) is ideally measured in very low-density lipoprotein (VLDL)-triacylglycerol (TAG). In the fasting state, the majority of plasma TAG typically represents VLDL-TAG; however, the merits of measuring DNL in total ...
Leanne Hodson   +6 more
doaj   +1 more source

Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis.

open access: yesJournal of Clinical Investigation, 2019
Deciphering novel pathways regulating liver lipid content has profound implications for understanding the pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Ji-Yeon Shin   +9 more
semanticscholar   +1 more source

ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance [PDF]

open access: hybridJournal of Lipid Research, 2001
Apolipoprotein (apo)A-II is a major high density lipoprotein (HDL) protein; however, its role in lipoprotein metabolism is largely unknown. Transgenic (Tg) mice that overexpress human apoA-II present functional lecithin: cholesterol acyltransferase deficiency, HDL deficiency, hypertriglyceridemia and, when fed an atherogenic diet, increased non-HDL ...
Joan Carles Escolà‐Gil   +5 more
openalex   +5 more sources

Dysfunctional VLDL metabolism in MASLD [PDF]

open access: yesnpj Metabolic Health and Disease
AbstractLipidomics has unveiled the intricate human lipidome, emphasizing the extensive diversity within lipid classes in mammalian tissues critical for cellular functions. This diversity poses a challenge in maintaining a delicate balance between adaptability to recurring physiological changes and overall stability.
Urko M. Marigorta   +3 more
openaire   +4 more sources

The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

open access: yesInternational Journal of Molecular Sciences, 2018
Apolipoprotein E receptor 2 (ApoER2) and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with ...
P. Dlugosz, J. Nimpf
semanticscholar   +1 more source

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms.

open access: yesJCI Insight, 2018
Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Dietary interventions based on protein restriction (PR) reduce circulating triglycerides (TGs), but underlying mechanisms and clinical relevance remain unclear.
J. H. Treviño-Villarreal   +25 more
semanticscholar   +1 more source

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