Results 41 to 50 of about 66,180 (284)

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

Diabetes, 2014
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG).
J. Geerling, M. Boon, G. van der Zon, S. V. D. van den Berg, A. M. van den Hoek, M. Lombès, H. Princen, L. Havekes, P. Rensen, B. Guigas   +9 more
semanticscholar   +1 more source

Postprandial VLDL lipolysis products increase monocyte adhesion and lipid droplet formation via activation of ERK2 and NFκB.

American Journal of Physiology. Heart and Circulatory Physiology, 2014
Postprandial lipemia is characterized by a transient increase in circulating triglyceride-rich lipoproteins such as very low-density lipoprotein (VLDL) and has been shown to activate monocytes in vivo.
Laura J. den Hartigh, Robin Altman, J. Norman, J. Rutledge   +3 more
semanticscholar   +1 more source

FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver.

Endocrinology, 2014
Excessive production of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to hypertriglyceridemia in obesity and type 2 diabetes. To understand the underlying mechanism, we studied hepatic regulation of VLDL-TG production by (forkhead
Dae Hyun Kim, Ting Zhang, Sojin Lee, V. Calabuig-Navarro, J. Yamauchi, Ann R. Piccirillo, Yong-Jun Fan, R. Uppala, E. Goetzman, H. H. Dong   +9 more
semanticscholar   +1 more source

CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice[S]

Journal of Lipid Research, 2013
Recent findings described the role of CD36-mediated signaling in regulating cellular calcium and the release of various bioactive molecules, including the prostaglandins, neurotransmitters, cholecystokinin, and secretin. Here we document the role of CD36
F. Nassir, Okunade L Adewole, E. Brunt, N. Abumrad   +3 more
semanticscholar   +1 more source

Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol

Diabetes, 2013
The aim was to determine whether fed VLDL and chylomicron (CM) triacylglycerol (TAG) production rates are elevated in metabolic syndrome (MetS). Eight men with MetS (BMI 29.7 ± 1.1) and eight lean age-matched healthy men (BMI 23.1 ± 0.4) were studied ...
F. Shojaee-Moradie, Yuying Ma, Shao-ying Lou, R. Hovorka, A. Umpleby   +4 more
semanticscholar   +1 more source

Systemic Review to Explore the Effect of Dyslipidaemia and Metabolic Function in Coronary Heart Disease with Type 2 Diabetes Mellitus: In Tertiary Care Center

Journal of Pharmacy and Bioallied Sciences
Metabolic dyslipidemia (high triglyceride) and low high-density lipoprotein cholesterol (HDL-C) are highly prevalent in type 2 diabetes mellitus (T2DM).
Akansha Singh, Ranjit S. Ambad, Roshan K. Jha   +2 more
doaj   +1 more source

CideB Protein Is Required for the Biogenesis of Very Low Density Lipoprotein (VLDL) Transport Vesicle*

Journal of Biological Chemistry, 2013
Background: Nascent VLDL exits the ER in a specialized large vesicle, the VTV. Results: CideB interacts with COPII proteins, and CideB ablation abrogates VTV biogenesis.
Samata Tiwari, S. Siddiqi, S. Siddiqi
semanticscholar   +1 more source

Bariatric surgery improves postprandial VLDL kinetics and restores insulin-mediated regulation of hepatic VLDL production

JCI Insight, 2023
Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (RYGB) surgery on postprandial VLDL1 and VLDL2 apoB and TG kinetics and their relationship with insulin ...
Vehpi Yildirim, Kasper W. ter Horst, Pim W. Gilijamse, Dewi van Harskamp, Henk Schierbeek, Hans Jansen, Alinda W.M. Schimmel, Max Nieuwdorp, Albert K. Groen, Mireille J. Serlie, Natal A.W. van Riel, Geesje M. Dallinga-Thie   +11 more
openaire   +4 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source