Results 51 to 60 of about 66,180 (284)

Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides

Nature, 2011
Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce the levels of low-density lipoprotein (LDL)-associated cholesterol.
K. Rayner, Christine Esau, F. N. Hussain, Allison L. McDaniel, Stephanie M. Marshall, J. V. van Gils, T. D. Ray, Frederick J. Sheedy, L. Goedeke, Xueqing Liu, O. Khatsenko, V. Kaimal, C. Lees, C. Fernández-Hernando, E. Fisher, R. Temel, K. Moore   +16 more
semanticscholar   +1 more source

Surface Engineering of Thrombus‐Targeting Nanocarriers for Cardiovascular Diseases: A Short Review

Advanced Materials Interfaces, EarlyView.
This paper systematically introduces surface modification strategies for thrombus‐targeting nanocarriers, highlights the clinical significance of nanocarrier‐based thrombolysis therapies, and prospects the synergy of combing thrombolysis and anti‐inflammatory therapies for enhanced therapeutic effect.
Xinyue Ge, Lei Ding, Wenjun Zhao, Bohan Cui, Xiang Guan, Mingfei Pan, Qingguo Li, Ning Gu   +7 more
wiley   +1 more source

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System

Diabetes, 2012
Excessive secretion of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to diabetic dyslipidemia. Earlier studies have indicated a possible role for the hypothalamus and autonomic nervous system in the regulation of VLDL-TG.
E. Bruinstroop, Lei Pei, M. Ackermans, E. Foppen, Anke J. Borgers, J. Kwakkel, A. Alkemade, E. Fliers, A. Kalsbeek   +8 more
semanticscholar   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation[S]

Journal of Lipid Research, 2012
Regulation of hepatic very low density lipoprotein (VLDL) assembly and maturation is crucial in controlling lipid homeostasis and in the development of metabolic disorders, including obesity, hepatic steatosis, and insulin resistance.
Xuanhe Li, Jing Ye, Linkang Zhou, W. Gu, E. Fisher, Peng Li   +5 more
semanticscholar   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Enhanced Separation of Extracellular Vesicles Using Capillary Isotachophoresis With Spacer Compounds

ELECTROPHORESIS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are pivotal in numerous physiological and pathological processes, such as immune responses, viral pathogenesis, pregnancy, cardiovascular diseases, and cancer progression. Their capacity to influence complex intracellular pathways highlights their therapeutic potential in addressing various conditions, including ...
Milan Pieter Paul de Putter, Andrea Capuano, Meia Numan, Thomas Hankemeier, Yuliya Shakalisava   +4 more
wiley   +1 more source

Actinidia spp. (Kiwifruit): A Comprehensive Review of Its Nutraceutical Potential in Disease Mitigation and Health Enhancement

Food Frontiers, EarlyView.
Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha, Nida Rehman, Rimsha Anwar, Hina Rasheed, Roshina Rabail, Zuhaib F. Bhat, Amin Mousavi Khaneghah, Rana Muhammad Aadil   +7 more
wiley   +1 more source

GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice

PLoS ONE, 2012
Objective In addition to improve glucose intolerance, recent studies suggest that glucagon-like peptide-1 (GLP-1) receptor agonism also decreases triglyceride (TG) levels. The aim of this study was to evaluate the effect of GLP-1 receptor agonism on very-
E. Parlevliet, Yanan Wang, J. Geerling, J. P. Schröder-van der Elst, K. Picha, K. O'Neil, V. Stojanovic-Susulic, T. Ort, L. Havekes, J. Romijn, H. Pijl, P. Rensen   +11 more
semanticscholar   +1 more source

Mature VLDL Particles Exit the Golgi in Distinct Post‐Golgi VLDL Vesicles

The FASEB Journal, 2013
Post‐Golgi transport of VLDL is crucial for maintaining normal triacylglycerol (TAG) homeostasis of hepatocytes, however, nothing is known about the exit of VLDLs from the Golgi. To study this important process, we established an in vitro Golgi‐budding assay to examine the formation of Golgi‐derived VLDL vesicles using hepatic Golgi containing [3H]TAG ...
Shadab A. Siddiqi, Tanvir Hossain, Shaila Siddiqi   +2 more
openaire   +1 more source