Results 51 to 60 of about 106,533 (346)

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Journal of Lipid Research, 2015
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased ...
Yan Wang, V. Gusarova, S. Banfi, J. Gromada, Jonathan C. Cohen, H. Hobbs   +5 more
semanticscholar   +1 more source

ABNORMALITY OF LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS TYPE 1 AND POOR GLYCEMIC CONTROL WITH AND WITHOUT DIABETIC MICROANGIOPATHIES

Acta Biomedica Scientifica, 2016
Hyperglycemia and dyslipidemia are common metabolic abnormalities in adults with type 1 diabetes mellitus (T1DM) and both increase cardiovascular disease risk.
V. S. Syomshchikov, L. Y. Khamnueva, E. V. Chugunova   +2 more
doaj   +1 more source

Moderate exercise increases affinity of large very low density lipoproteins for hydrolysis by lipoprotein lipase [PDF]

, 2015
Context: Postprandial triglyceride (TG) concentration is independently associated with cardiovascular disease risk. Exercise reduces postprandial TG concentrations but the mechanisms responsible are unclear.
Bedford, Dorothy K., Caslake, Muriel J., Cooney, Josephine, GHAFOURI, Khloud, Gill, Jason M.R., Wilson, John   +5 more
core   +1 more source

Moderate dyslipoproteinemia induced inflammation and remodeling HDL and VLDL particles in post-renal transplant patients

Current Issues in Pharmacy and Medical Sciences, 2017
The aim of this paper was to examine whether moderate dyslipoproteinemia can cause an increase of hsCRP and LPO levels in Tx patients who had received immunosuppressive therapy and were without acute inflammatory diseases. Herein, the lipid levels, hsCRP,
Kimak Elzbieta, Baranowicz-Gaszczyk Iwona, Bialopiotrowicz Tomasz   +2 more
doaj   +1 more source

The role of lipid and lipoprotein metabolism in non-alcoholic fatty liver disease [PDF]

, 2017
Due to the epidemic of obesity across the world, nonalcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disorders in children and adolescents.
Anania, Caterina, Lavorato, Michela, Perla, Francesco Massimo, Prelati, Maurizia, Visicchio, Daniele   +4 more
core   +2 more sources

Studies on the Diagnosis of Type III Hyperlipoproteinemia A suggestion of chemical criteria based on VLDL-cholesterol and VLDL-cholesterol/VLDL-triglyceride

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1977
血中リポ蛋白の中間代謝産物 (ILDL, remnant) が異常に増加するIII型高脂血症は, 血清 Chol, TG値からは診断できず, 超遠心分離および電気泳動により, β-VLDLを証明する必要がある. しかしβ-VLDLの証明はやや客観性に乏しく, 本症診断における特異性にも問題がある. 最近III型高脂血症に特異的で感度の高い診断方法が数多く報告されているが, 未だ十分なものはない. 今回我々は, 臨床像およびリポ蛋白泳動によりβ-VLDLを証明した典型的なIII型高脂血症と思われる症例の血清脂質およびリポ蛋白を頻回に測定し, 他のタイプの高脂血症と比較検討し, 以下の結論を得た.1) III型高脂血症の血清 Chol は182～540mg/dlでTGは142～898mg/dlであった.
Hiroshi Mabuchi, Kosei Ueda, Ryosei Ueda, Ryozo Tatami, Toshihiro Haba, Tomio Kametani, Seigo Ito, Junji Koizumi, Masayuki Oota, Susumu Miyamoto, Ryoyu Takeda   +10 more
openaire   +4 more sources

VLDL Biogenesis and Secretion: It Takes a Village

Circulation Research, 2023
The production and secretion of VLDLs (very-low-density lipoproteins) by hepatocytes has a direct impact on liver fat content, as well as the concentrations of cholesterol and triglycerides in the circulation and thus affects both liver and cardiovascular health, respectively. Importantly, insulin resistance, excess caloric intake, and lack of physical
Willemien van Zwol, Bart van de Sluis, Henry N. Ginsberg, Jan Albert Kuivenhoven   +3 more
openaire   +2 more sources

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

Diabetes, 2014
Metformin is the first-line drug for the treatment of type 2 diabetes. Besides its well-characterized antihyperglycemic properties, metformin also lowers plasma VLDL triglyceride (TG).
J. Geerling, M. Boon, G. van der Zon, S. V. D. van den Berg, A. M. van den Hoek, M. Lombès, H. Princen, L. Havekes, P. Rensen, B. Guigas   +9 more
semanticscholar   +1 more source

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source

Postprandial VLDL lipolysis products increase monocyte adhesion and lipid droplet formation via activation of ERK2 and NFκB.

American Journal of Physiology. Heart and Circulatory Physiology, 2014
Postprandial lipemia is characterized by a transient increase in circulating triglyceride-rich lipoproteins such as very low-density lipoprotein (VLDL) and has been shown to activate monocytes in vivo.
Laura J. den Hartigh, Robin Altman, J. Norman, J. Rutledge   +3 more
semanticscholar   +1 more source