Results 21 to 30 of about 53,616 (262)
npj Vaccines, 2023 Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity compared to soluble proteins. We hypothesised that immune responses can be further improved by increasing the antigen density on the surface of VLPs.
F. Tarrés-Freixas +20 more
semanticscholar +1 more source
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Virus‐like particle (VLP) Peanut is a novel immunotherapeutic vaccine candidate for the treatment of peanut allergy. The active pharmaceutical ingredient represents cucumber mosaic VLPs (CuMVTT‐VLPs) that are genetically fused with one of the major ...
Pascal S. Krenger +11 more
semanticscholar +1 more source
Journal of Virology, 2022 Licensed preventive HPV vaccines are composed of VLPs derived by expression of major capsid protein L1. They confer protection generally restricted to infection by the αHPVs targeted by the up-to-9-valent vaccine, and their associated anogenital cancers ...
Pola Olczak +10 more
semanticscholar +1 more source
Mechanisms of cellular and humoral immunity through the lens of VLP-based vaccines
Expert Review of Vaccines, 2022 Introduction Vaccination can be effective defense against many infectious agents and the corresponding diseases. Discoveries elucidating the mechanisms of the immune system have given hopes to developing vaccines against diseases recalcitrant to current ...
Hunter McFall-Boegeman, Xuefei Huang
semanticscholar +1 more source
Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]
, 2020 Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core +2 more sources
RG1-VLP and Other L2-Based, Broad-Spectrum HPV Vaccine Candidates
Journal of Clinical Medicine, 2021 Licensed human papillomavirus (HPV) vaccines contain virus-like particles (VLPs) self-assembled from L1 major-capsid proteins that are remarkably effective prophylactic immunogens.
B. Huber +3 more
semanticscholar +1 more source
Designing a therapeutic hepatitis B vaccine to circumvent immune tolerance
Human Vaccines & Immunotherapeutics, 2020 An effective prophylactic hepatitis B virus (HBV) vaccine has long been available but is ineffective for chronic infection. The primary cause of chronic hepatitis B (CHB) and greatest impediment for a therapeutic vaccine is the direct and indirect ...
DC Whitacre +11 more
doaj +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2021 Introduction. Pneumonia often occurs secondary to influenza infection and accounts for a large proportion of the morbidity and mortality associated with seasonal and pandemic influenza outbreaks.
I. A. Leneva +5 more
doaj +1 more source
Vaccines, 2020 The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral
Rosamund Chapman +10 more
doaj +1 more source
Vaccines, 2021 The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic had brought disastrous consequences throughout the entire world. While several manufactured vaccines have been approved for emergency use, continuous efforts to generate ...
Ki-Back Chu +6 more
semanticscholar +1 more source