Results 31 to 40 of about 23,750 (257)

RNA: packaged and protected by VLPs

RSC Advances, 2018
VLP packaging is most efficient for compact RNA, and protects RNA against assault by small diffusible damaging agents.
Po-Yu Fang, Jessica C. Bowman, Lizzette M. Gómez Ramos, Chiaolong Hsiao, Loren Dean Williams   +4 more
openaire   +3 more sources

Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

Viruses, 2022
In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein virus-like particle (M2e5x VLP) into a pre-crosslinked bovine serum albumin (BSA) polymeric matrix enhances in vitro antigen immunogenicity and in vivo ...
Keegan Braz Gomes, Ipshita Menon, Priyal Bagwe, Lotika Bajaj, Sang-Moo Kang, Martin J. D’Souza   +5 more
doaj   +1 more source

Promotion of Cellular and Humoral Immunity against Foot-and-Mouth Disease Virus by Immunization with Virus-Like Particles Encapsulated in Monophosphoryl Lipid A and Liposomes

Vaccines, 2020
Virus-like particles (VLPs) have emerged as promising vaccine candidates against foot-and-mouth disease (FMD). However, such vaccines provide a relatively low level of protection against FMD virus (FMDV) because of their poor immunogenicity.
Woo Sik Kim, Yong Zhi, Huichen Guo, Eui-Baek Byun, Jae Hyang Lim, Ho Seong Seo   +5 more
doaj   +1 more source

Pigs Immunized with the Virus-like Particle Vaccine Are Protected against the Hepatitis E-3 Virus

Vaccines, 2021
In this study, we generated the HEV virus-like particle (VLP) vaccine expressing 239 amino acids (367–605 aa) of the HEV-3 ORF2 using the baculovirus expression system.
Hyeon-Jeong Go, Byung-Joo Park, Hee-Seop Ahn, Dong-Hwi Kim, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Yang-Kyu Choi, In-Soo Choi   +11 more
doaj   +1 more source

Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV

Viruses, 2019
Human cytomegalovirus (HCMV) infects more than 70% of the human population worldwide. HCMV is responsible for high morbidity and mortality in immunocompromised patients and remains the leading viral cause of congenital birth defects. Despite considerable
Michela Perotti, Laurent Perez
doaj   +1 more source

Safety and immunogenicity of VLPCOV-02, a SARS-CoV-2 self-amplifying RNA vaccine with a modified base, 5-methylcytosine

iScience
Summary: Continuing emergence of variants of concern resulting in reduced SARS-CoV-2 vaccine efficacy necessitates additional prevention strategies. The structure of VLPCOV-01, a lipid nanoparticle-encapsulated, self-amplifying RNA COVID-19 vaccine with ...
Masayuki Aboshi, Kenta Matsuda, Daisuke Kawakami, Kaoru Kono, Yoko Kazami, Takashi Sekida, Mai Komori, Amber L. Morey, Shigeru Suga, Jonathan F. Smith, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Nobuaki Sato, Wataru Akahata   +14 more
doaj   +1 more source

Transdermal Vaccination with the Matrix-2 Protein Virus-like Particle (M2e VLP) Induces Immunity in Mice against Influenza A Virus

Vaccines, 2021
In this study, our goal was to utilize the extracellular domain matrix-2 protein virus-like particle (M2e VLP) that has been found to be highly conserved amongst all strains of influenza and could serve as a potential vaccine candidate against influenza.
Kimberly Braz Gomes, Sucheta D’Sa, Grace Lovia Allotey-Babington, Sang-Moo Kang, Martin J. D’Souza   +4 more
doaj   +1 more source

Molecular pharming — VLPs made in plants

Current Opinion in Biotechnology, 2016
Plant-based expression offers a safe, inexpensive and potentially limitless way to produce therapeutics in a quick and flexible manner. Plants require only simple inorganic nutrients, water, carbon dioxide and sunlight for efficient growth. Virus-like particles (VLPs) are convincing look-alikes of viruses but without carrying infectious genomic ...
Marsian, Johanna, Lomonossoff, George P
openaire   +2 more sources

0. Prologue | The 2023 UCF VLP Institute Podcast Series

, 2023
Welcome to The 2023 UCF Veterans Legacy Program (VLP) Institute Podcast Series, a limited narrative podcast series directed, produced, written, edited, and hosted by Sebastian Garcia.
Garcia, Sebastian
core  

7. “That Felt So Personal” | The 2023 UCF VLP Institute Podcast Series

, 2023
In the seventh episode of “The 2023 UCF VLP Institute Podcast Series,” we pick back up where we left off last week: the conclusion of the “meta” field trip and into the roundtable discussion about it.
Garcia, Sebastian
core