Results 51 to 60 of about 18,155 (206)

THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj  

Fluid‐induced slip on a rate‐and‐state fault during co‐ and post‐injection: The interplay of fluid pressure diffusion and poroelastic stress

Deep Underground Science and Engineering, EarlyView.
Fault slip can occur ahead of the injection pressure front due to poroelastic stress. Our model captures the interaction of pressure, stress, and friction, providing new insights into injection‐induced seismicity and post‐injection fault slip. Shut‐in operations can either mitigate or accelerate seismic events depending on fault conditions and ...
Qifeng Xie, Lei Wang, Qi Li
wiley   +1 more source

Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells. [PDF]

PLoS ONE, 2013
Our previous study has shown that mesothelin (MSLN) is a potential immunotherapeutic target for pancreatic cancer. Here, we further studied the immunogenicity of chimeric murine MSLN-virus-like particles (mMSLN-VLPs), their ability to break tolerance to ...
Sheng Zhang, Lin-Kin Yong, Dali Li, Rafael Cubas, Changyi Chen, Qizhi Yao   +5 more
doaj   +1 more source

The pandemic generation: Investigating the long‐term impact of a large‐scale stressor on the anxiety of children

JCPP Advances, EarlyView.
Abstract Background As a large‐scale global stressor, the COVID‐19 pandemic has a substantial impact on the mental health of children and adolescents. In this longitudinal study we investigate long‐term trajectories of anxiety of children during and after the pandemic (April 2020–April 2023), and identify associated risk factors. Methods A total of 514
Michiel A. J. Luijten, Hedy A. van Oers, Jacintha M. Tieskens, Marlene A. Werner, Josjan Zijlmans, Lotte Haverman, Tinca J. C. Polderman, Lianne P. de Vries   +7 more
wiley   +1 more source

Beta Human Papillomaviruses Seropositivity and the Association With Cutaneous Squamous Cell Carcinoma—A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common nonmelanoma skin cancers, with increasing incidence globally. Beta genus human papillomaviruses (β‐HPVs), particularly in immunocompromised individuals, have been implicated in the development of cSCC. However, the strength of association between β‐HPV seropositivity
Shweh Fern Loo, Ci Zhuang Teh, Wanni Chia, Choon Chiat Oh   +3 more
wiley   +1 more source

Significance of VLPs in Vlp-circRNA vaccines: a vaccine candidate or delivery vehicle?

RNA Biology
Circular RNAs (circRNAs) are a class of single-stranded RNAs with a closed loop lacking 5' and 3' ends. These circRNAs are translatable and, therefore, have a potential in developing vaccine. CircRNA vaccines have been shown to be more stable, safe, easy to manufacture and scale-up production when compared to mRNA vaccines. However, these vaccines also
Reeshu Gupta, Kajal Arora, Nupur Mehrotra Arora, Prabuddha Kundu   +3 more
openaire   +3 more sources

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, EarlyView.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source

Relating gas ascent to eruption triggering for the April 27, 2016, White Island (Whakaari), New Zealand eruption sequence

Earth, Planets and Space, 2018
The April 27, 2016 eruption sequence at White Island was comprised of 6 discrete eruptive events that occurred over a 35-min period. Seismicity included three episodes of VLP activity: the first occurring ~ 2 h and a second occurring 10 min prior to the ...
Arthur Jolly, Ivan Lokmer, Bruce Christenson, Johannes Thun   +3 more
doaj   +1 more source

Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine. [PDF]

PLoS ONE, 2012
Murabutide (MB) is a synthetic immunomodulator recognized by the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptor on mammalian cells. MB has previously been approved for testing in multiple human clinical trials to determine
Erin M Jackson, Melissa M Herbst-Kralovetz   +1 more
doaj   +1 more source

Advances and challenges in experimental models for Epstein–Barr virus research

mLife, EarlyView.
Abstract Epstein–Barr virus (EBV), the first identified human oncovirus, is a ubiquitous γ‐herpesvirus etiologically linked to diverse malignancies, lymphoproliferative disorders, and autoimmune diseases. Experimental models are pivotal for unraveling the infection and pathogenesis mechanisms, life cycle regulation, as well as development and ...
Gulimire Wufuer, Jiabao Tang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +5 more
wiley   +1 more source