Results 71 to 80 of about 23,750 (257)

EBO-VLP causes iBRB breakdown through pericytes secretion of VEGF.

, 2023
(A-B) Integrity of the tri-culture iBRB model after EBO-VLP, EBO-VLP + Avastin and VEGF treatment. Na-F permeability (A) and the TEER values (B) of the iBRB model were examined 48 h after EBO-VLP administration.
Xiaowei Zhang (6505), Wei Li (7081), Xian-En Zhang (9589), Zhengyuan Guo (8922134), Jiawang Gao (12516715), Zongqiang Cui (168558)   +5 more
core   +1 more source

The pandemic generation: Investigating the long‐term impact of a large‐scale stressor on the anxiety of children

JCPP Advances, EarlyView.
Abstract Background As a large‐scale global stressor, the COVID‐19 pandemic has a substantial impact on the mental health of children and adolescents. In this longitudinal study we investigate long‐term trajectories of anxiety of children during and after the pandemic (April 2020–April 2023), and identify associated risk factors. Methods A total of 514
Michiel A. J. Luijten, Hedy A. van Oers, Jacintha M. Tieskens, Marlene A. Werner, Josjan Zijlmans, Lotte Haverman, Tinca J. C. Polderman, Lianne P. de Vries   +7 more
wiley   +1 more source

The choice of resin-bound ligand affects the structure and immunogenicity of column-purified human papillomavirus type 16 virus-like particles. [PDF]

PLoS ONE, 2012
Cell growth conditions and purification methods are important in determining biopharmaceutical activity. However, in studies aimed at manufacturing virus-like particles (VLPs) for the purpose of creating a prophylactic vaccine and antigen for human ...
Hyoung Jin Kim, Su Jeung Lim, Hye-Lim Kwag, Hong-Jin Kim   +3 more
doaj   +1 more source

VLP vaccination and sampling schedule of mice and VLP-specific humoral immune response.

, 2013
(A) Timeline of study 1 vaccinations and sample collection days. Serum VLP-specific IgG (B), IgG1 (C), IgG2a (D), and IgA (E) production following IN delivery of VLP and MB (25 µg, 100 µg, or 250 µg), MB alone (250 µg), VLP and alum delivered ...
Melissa M. Herbst-Kralovetz (314322), Erin M. Jackson (314320)   +1 more
core   +1 more source

THE RECOMBINANT ANTIGENS FOR VACCINES FOR THE TREATMENT OF PAPILLOMAVIRUS (REVIEW)

Разработка и регистрация лекарственных средств, 2019
Two licensed vaccines Gardasil and Cervarix, containing main capsid protein L1 virus-like particles antigen, are used for prevention of diseases associated with human papilloma virus.
M. A. Zhuchenko
doaj  

Beta Human Papillomaviruses Seropositivity and the Association With Cutaneous Squamous Cell Carcinoma—A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common nonmelanoma skin cancers, with increasing incidence globally. Beta genus human papillomaviruses (β‐HPVs), particularly in immunocompromised individuals, have been implicated in the development of cSCC. However, the strength of association between β‐HPV seropositivity
Shweh Fern Loo, Ci Zhuang Teh, Wanni Chia, Choon Chiat Oh   +3 more
wiley   +1 more source

A cholesterol-lowering VLP vaccine that targets PCSK9 [PDF]

Vaccine, 2015
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protein that controls cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the low-density lipoprotein receptor (LDL-R). Mutations that cause increased activity of PCSK9 are associated with hypercholesterolemia, atherosclerosis and early cardiovascular disease ...
Erin, Crossey, Marcelo J A, Amar, Maureen, Sampson, Julianne, Peabody, John T, Schiller, Bryce, Chackerian, Alan T, Remaley   +6 more
openaire   +2 more sources

Voice and Speech in Atypical Parkinsonian Disorders

Movement Disorders Clinical Practice, EarlyView.
Background Motor speech disorders are early, common, and functionally limiting features of atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA). These impairments are underrecognized and undertreated in neurology clinics.
Federico Rodriguez‐Porcel, Farwa Ali, Michiko Bruno, Heather Davis Cuevas, Rohit Dhall, Kylie Dunne‐Platero, Lawrence I. Golbe, Ihtsham Haq, Nicole Herndon, Lawrence S. Honig, Kyurim Kang, Sarah Kremen, Guillaume Lamotte, Nikolaus R. McFarland, Michela Mir, Leila Montaser‐Kouhsari, Alexander Pantelyat, Joel Page, Hylan Pickett, Laura Purcell Verdun, Kelly Richardson, Jessica Shurer, Michelle Troche, Rene L. Utianski, Katya Villarreal‐Cavazos, Tuhin Virmani, Anne‐Marie Wills, as the Diagnosis and Treatment Working Group, CurePSP Center of Care (CoC) Network, Farwa Ali, Michiko Bruno, Timothy Chang, Rohit Dhall, Kimiko Domoto‐Reilly, Lawrence I. Golbe, Ihtsham Haq, Lawrence S. Honig, Sarah Kremen, Guillaume Lamotte, Zoltan Mari, Nikolaus R. McFarland, Leila Montaser‐Kouhsari, Alexander Pantelyat, Federico Rodriguez‐Porcel, Junaid Siddiqui, Jessica Shurer, Christopher Spears, Tuhin Virmani, Anne‐Marie Wills   +48 more
wiley   +1 more source

Temporal Dynamics of Parkinson's Disease Tremor: Clinical and Neuroimaging Insights

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is a progressive neurodegenerative disorder clinically defined by three cardinal motor symptoms: bradykinesia, rigidity, and tremor. Although the natural history of bradykinesia and rigidity is well described, the evolution of tremor as the disease progresses remains controversial. Objectives The goal was to
Melanie Suette, Robert Matic, Marisa Koini, Lukas Gattermeyer‐Kell, Daniela Kern, Petra Katschnig‐Winter, Mariella Koegl, Maximilian Sackl, Christian Tinauer, Birgit Helmlinger, Manuel Leitner, Stefan Ropele, Daniela Pinter, Christian Enzinger, Stephan Seiler, Petra Schwingenschuh   +15 more
wiley   +1 more source

Influence of antigen density and TLR ligands on preclinical efficacy of a VLP-based vaccine against peanut allergy. [PDF]

BACKGROUND Virus-like particle (VLP) Peanut is a novel immunotherapeutic vaccine candidate for the treatment of peanut allergy. The active pharmaceutical ingredient represents cucumber mosaic VLPs (CuMVTT -VLPs) that are genetically fused with one of ...
Zeltins, Andris, Scott, Callum J W, Heath, Matthew D, Hewings, Simon, Krenger, Pascal S, Velazquez, Thalia L C, Sobczak, Jan, Kramer, Matthias F, Bachmann, Martin F, Josi, Romano, Balke, Ina, Skinner, Murray A   +11 more
core   +1 more source