Results 81 to 90 of about 23,750 (257)

Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine. [PDF]

PLoS ONE, 2012
Murabutide (MB) is a synthetic immunomodulator recognized by the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptor on mammalian cells. MB has previously been approved for testing in multiple human clinical trials to determine
Erin M Jackson, Melissa M Herbst-Kralovetz   +1 more
doaj   +1 more source

Deep Reinforcement Learning Based Autonomous Decision‐Making for Cooperative Uncrewed Aerial Vehicles: A Search and Rescue Real World Application

Journal of Field Robotics, EarlyView.
ABSTRACT This paper presents the first end‐to‐end framework that combines guidance, navigation, and centralized task allocation for multiple UAVs performing autonomous search‐and‐rescue (SAR) in GNSS‐denied indoor environments. A twin delayed deep deterministic policy gradient controller is trained with an artificial potential field (APF) reward that ...
Thomas Hickling, Maxwell Hogan, Abdulla Tammam, Nabil Aouf   +3 more
wiley   +1 more source

Immunogenicity of VLP-VP2 in mice (determination of antibody titers of VLP-VP2 in mice).

, 2014
Immunogenicity of VLP-VP2 in mice (determination of antibody titers of VLP-VP2 in mice).
Yu-wei Gao (510434), Xue-xing Zheng (510432), Hao Feng (54208), Hua-lei Wang (510428), Meng Liang (375583), Zhi-fang Zhang (5657590), Gui-qiu Hu (510427), Xian-zhu Xia (510436), He Guo (218473), Hongru Liang (510429), Song-tao Yang (510435), Pingsen Zhao (510430), Yu-jiao Yang (510431), Yong-kun Zhao (510433)   +13 more
core   +1 more source

Ground‐based robotic remote sensing for standardized biodiversity monitoring in coastal habitats

Remote Sensing in Ecology and Conservation, EarlyView.
Illustrated workflow of the proposed citizen‐to‐robot monitoring pipeline: (i) expert‐validated citizen observations are translated into AI models, (ii) deployed on a ground‐based robotic platform for proximal sensing of coastal dune habitats, (iii) enabling standardized detection of ecological targets (e.g., Pancratium maritimum & Brithys crini), and (
Giovanni Di Lorenzo, Simonetta Bagella, Micaela del Valle Rasino, Maria Laura Carranza, Manolo Garabini, Franco Angelini   +5 more
wiley   +1 more source

Immunomodulation and Vaccination with RHDV VLP [PDF]

, 2017
Colorectal cancer (CRC) is an insidious disease, responsible for almost 700,000 deaths annually worldwide. The incidence of CRC in New Zealand is more than double the world average, at 48.1 and 36.7 cases per 100,000 annually for men and women ...
Donaldson, Braeden Carl
core   +1 more source

Relating gas ascent to eruption triggering for the April 27, 2016, White Island (Whakaari), New Zealand eruption sequence

Earth, Planets and Space, 2018
The April 27, 2016 eruption sequence at White Island was comprised of 6 discrete eruptive events that occurred over a 35-min period. Seismicity included three episodes of VLP activity: the first occurring ~ 2 h and a second occurring 10 min prior to the ...
Arthur Jolly, Ivan Lokmer, Bruce Christenson, Johannes Thun   +3 more
doaj   +1 more source

Peptide‐Ligand Cooperative Interplay Drives Gold Nanoparticle Encapsulation by Protein Cages

Small, EarlyView.
Gold nanoparticle encapsulation within protein cages is governed by salt‐dependent binding energetics and cooperative peptide–ligand interactions. Ligands enhance electrostatic attraction while peptides extend recruitment and prevent kinetic trapping, enabling robust cargo loading. This molecular‐level insight links experiments and simulations, guiding
Wenhui Li, Niklas Mucke, Michael Rütten, Tommaso L. Schweers, Tobias Beck, Vikram Jadhao   +5 more
wiley   +1 more source

Display of malaria transmission-blocking antigens on chimeric duck hepatitis B virus-derived virus-like particles produced in Hansenula polymorpha.

PLoS ONE, 2019
BACKGROUND:Malaria caused by Plasmodium falciparum is one of the major threats to human health globally. Despite huge efforts in malaria control and eradication, highly effective vaccines are urgently needed, including vaccines that can block malaria ...
David Wetzel, Jo-Anne Chan, Manfred Suckow, Andreas Barbian, Michael Weniger, Volker Jenzelewski, Linda Reiling, Jack S Richards, David A Anderson, Betty Kouskousis, Catherine Palmer, Eric Hanssen, Gerhard Schembecker, Juliane Merz, James G Beeson, Michael Piontek   +15 more
doaj   +1 more source

High-Throughput Production of Influenza Virus-Like Particle (VLP) Array by Using VLP-factory™, a MultiBac Baculoviral Genome Customized for Enveloped VLP Expression [PDF]

, 2019
Baculovirus-based expression of proteins in insect cell cultures has emerged as a powerful technology to produce complex protein biologics for many applications ranging from multiprotein complex structural biology to manufacturing of therapeutic proteins including virus-like particles (VLPs).
Sari-Ak, Duygu, Bahrami, Shervin, Laska, Magdalena, Drncova, Petra, Fitzgerald, Daniel J, Berger-Schaffitzel, Christiane, Garzoni, Frederic, Berger, Imre   +7 more
openaire   +5 more sources

DNA‐Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity

Small, EarlyView.
DNA–enzyme hybrid nanostructures enable precise spatial and stoichiometric control over enzyme organization, offering a powerful platform to modulate catalytic activity. This review critically evaluates key mechanistic hypotheses, including proximity effects, microenvironment changes, confinement, and stabilization, as well as highlighting ...
Manar Elnaggar, Amelie Heuer‐Jungemann
wiley   +1 more source