Results 101 to 110 of about 25,779 (213)

Lipid A-modified Escherichia coli can produce porcine parvovirus virus-like particles with high immunogenicity and minimal endotoxin activity

Microbial Cell Factories
Background A cost-effective Escherichia coli expression system has gained popularity for producing virus-like particle (VLP) vaccines. However, the challenge lies in balancing the endotoxin residue and removal costs, as residual endotoxins can cause ...
Xuegang Shen, Yong-Bo Yang, Yanfei Gao, Shujie Wang, Haiwei Wang, Mingxia Sun, Fandan Meng, Yan-Dong Tang, Yabin Tu, Qingke Kong, Tong-Qing An, Xue-Hui Cai   +11 more
doaj   +1 more source

Microbiome Insights Into Zoonotic Risk at Wildlife–Human Interfaces in a Transitioning Landscape in Thailand

Integrative Zoology, EarlyView.
This study shows how ecological transitions, such as reforestation in Southeast Asia, reshape host–microbe–pathogen dynamics at the wildlife–domestic interface. By integrating long‐read microbiome sequencing, ecological gradients, and statistical and network analysis, we identify host species that disproportionately contribute to pathogen diversity and
Pauline Van Leeuwen, Chuanpot Thinphovong, Vincent Sluydts, Alix Nicolas, Anamika Kritiyakan, Areeya Kriengudom, Pipat Soisook, Kittipong Chaisiri, Serge Morand, Johan Michaux   +9 more
wiley   +1 more source

Evaluation of cellular immune response and biosafety of SV40 virus-like particle in tumor immunotherapy

Journal of Materials Science: Materials in Medicine
Virus-like particle (VLP) holds great promise for applications in vaccines and tumor immunotherapy. However, their clinical translation has been limited by a lack of comprehensive in vivo studies on immune responses and antigenic toxicity. In this study,
Ting He, Ruoxuan Hei, Chong Liu, Huiping Wang, Zhaowei Gao, Ke Dong, Juan Zhang   +6 more
doaj   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, EarlyView.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Generation of chimeric HPV16 L1/L2-E7 VLP.

, 2015
A Sf-9 insect cells were infected with recombinant HPV16 L1/L2-E7 baculovirus and VLP purified by sucrose cushion and CsCl gradient centrifugation. Purified VLP, infected, and uninfected Sf-9 cell lysates were analyzed by SDS-PAGE and Coomassie staining.
Markus Wolschek (167359), Christoph Jindra (705992), Bettina Huber (705990), Thomas Muster (167361), Reinhard Kirnbauer (562348), Boris Ferko (225334), Sabine Brandt (123497), Saeed Shafti-Keramat (705994)   +7 more
core   +1 more source

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, EarlyView.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

Mannosylation enhances VLP binding and uptake by murine APCs.

, 2014
Murine splenocytes pulsed with DyLight labeled; VLP (white), monomannose-VLP (grey) or dimannose-VLP (black), were incubated at 4°C (B,D,F) or 37°C (C,E,G).
Margaret A. Baird (615879), David S. Larsen (615880), Sarah L. Young (615878), Vernon K. Ward (333594), Farah Al-Barwani (615877)   +4 more
core   +1 more source

ACE2-Decorated Virus-Like Particles Effectively Block SARS-CoV-2 Infection

International Journal of Nanomedicine
Canan Bayraktar,1,* Alisan Kayabolen,1,* Arda Odabas,1 Aysegul Durgun,1 Ipek Kok,1 Kenan Sevinc,1 Aroon Supramaniam,2 Adi Idris,2,3 Tugba Bagci-Onder1 1Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul ...
Bayraktar C, Kayabolen A, Odabas A, Durgun A, Kok I, Sevinc K, Supramaniam A, Idris A, Bagci-Onder T   +8 more
doaj  

Approximating multidimensionality with asymmetric unidimensional IRT models

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Unidimensional item response theory (IRT) models are widely used even in settings where assessment data exhibit subtle forms of multidimensionality. Recent empirical evidence suggests that when item difficulty is associated with dimensionality, asymmetric item characteristic curves (ICCs) emerge in the unidimensional approximation.
Xiangyi Liao, Yinqiu He, Daniel Bolt, James Soland, Carlin Conner, Emily J. Solari   +5 more
wiley   +1 more source

A nucleoside-modified mRNA vaccine forming rabies virus-like particle elicits strong cellular and humoral immune responses against rabies virus infection in mice

Emerging Microbes and Infections
Rabies is a lethal zoonotic disease that threatens human health. As the only viral surface protein, the rabies virus (RABV) glycoprotein (G) induces main neutralizing antibody (Nab) responses; however, Nab titre is closely correlated with the ...
Jie Liu, Jie Sun, Xue Ding, Wenhao Liu, Yipeng Wang, Zihan Wang, Hanyu Peng, Yong Zhang, Weiheng Su, Chunlai Jiang   +9 more
doaj   +1 more source