Results 121 to 130 of about 26,425 (258)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

A nucleoside-modified mRNA vaccine forming rabies virus-like particle elicits strong cellular and humoral immune responses against rabies virus infection in mice

Emerging Microbes and Infections
Rabies is a lethal zoonotic disease that threatens human health. As the only viral surface protein, the rabies virus (RABV) glycoprotein (G) induces main neutralizing antibody (Nab) responses; however, Nab titre is closely correlated with the ...
Jie Liu, Jie Sun, Xue Ding, Wenhao Liu, Yipeng Wang, Zihan Wang, Hanyu Peng, Yong Zhang, Weiheng Su, Chunlai Jiang   +9 more
doaj   +1 more source

E6-RHDV-VLP-PADRE immunisation reduces tumour burden and increases survival in mice with pre-existing TC-1 tumours.

, 2013
(a) C57BL/6 mice (eight per group) were inoculated with 1×105 TC-1 tumour cells/mouse s.c., vaccinated nine days later followed by a second vaccination after one week.
Sara McKee (421996), Vernon Ward (421997), Vivienne Young (421994), Khairunadwa Jemon (421993), Sarah Young (158443), Margaret Baird (421998), Merilyn Hibma (421999), Michelle Wilson (421995)   +7 more
core   +1 more source

Challenges in Gene‐Directed Therapies for Rare Neurodevelopmental Disorders Using HNRNPU as an Exemplar

Clinical Genetics, EarlyView.
Beyond diagnosing rare neurodevelopmental disorders like HNRNPU‐RNDD, developing gene‐directed therapies requires overcoming complex hurdles, including spatial, developmental, and cell‐type constraints. Addressing these requires understanding the molecular effects of dosage and chromatin dynamics to deliver precise, effective treatments.
Daniel Aiyedun, Susan F. Rogers, Doaa M. Taha, Meena Balasubramanian   +3 more
wiley   +1 more source

Biases and complementarity in gut viromes obtained from bulk and virus-like particle-enriched metagenomic sequencing

Microbiology Spectrum
Due to varying sequencing strategies, current gut virome findings show significant variability. Specifically, bulk- and virus-like particle (VLP)-enriched metagenomic sequencing (termed bulk and VLP, respectively) present unique advantages and ...
Yun Li, Chuqing Sun, Jiaying Zhu, Mingyan Geng, Min Li, Xing-Ming Zhao, Wei-Hua Chen   +6 more
doaj   +1 more source

Polyoma VLP and FITC-FSA uptake in renal medullary endothelial cells.

, 2014
Panels A–F: Mouse tissues were perfusion fixed 7 min after intravenous injection of BK-VLP (A–C), or JC-VLP (D–F), and paraffin sections double immune labeled with anti-BK-VP1 (red) and anti-Meca 32 (green). Panels A–C: Arrows indicate endothelial uptake
Bård Smedsrød (134170), Christine Hanssen Rinaldo (655630), Kjetil Elvevold (655634), Hans H. Hirsch (290600), Ruomei Li (655632), Jaione Simon-Santamaria (3598871), Ivana Malovic (655633), Piotr Kardas (655631), Peter McCourt (52244), Karen Kristine Sørensen (655635)   +9 more
core   +1 more source

Attention Based Optimization for 3D Shape Registration

Computer Graphics Forum, EarlyView.
Abstract Transformers are sequence‐to‐sequence architectures originally designed to handle structurally rigid and order‐sensitive data, such as text and images. At their core, they exploit the attention mechanism, which is permutation‐equivariant and relies on computing token‐to‐token relationships.
A. Riva, L. Olearo, S. Melzi
wiley   +1 more source

Macrophages are required for VLP-mediated post-exposure protection and IgG antibody production.

, 2015
(A) CD11b-DTR mice were depleted of macrophages by injection of diphtheria toxin, then infected with EBOV and treated with VLPs 24 hours post-infection, or left untreated.
Sina Bavari (154739), Carl I. Shaia (704916), Natarajan Ayithan (696321), Scott M. Anthony (531045), Kelly S. Stuthman (696322), Keiko Ozato (25065), Steven B. Bradfute (262649), Mike Bray (18300), Prafullakumar Tailor (704915)   +8 more
core   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Surgical Treatment of Distal Radius Fractures Using Minimally Invasive Plate Osteosynthesis or Open Reduction and Internal Fixation: A Five-Year Comparative Follow-Up Study

Applied Sciences
Distal radius fractures (DRFs) constitute one of the most prevalent injuries in adults. This study compares the clinical and radiological outcomes of intra- and extra-articular DRFs treated with percutaneous Kirschner wires (PKW) or volar locking plates (
Giuseppe Rovere, Pierfrancesco Pirri, Gianmarco Murgante, Vincenzo De Luna, Aurelio Testa, Giovanna Fidone, Francesco Liuzza, Pasquale Farsetti, Fernando De Maio   +8 more
doaj   +1 more source