Results 11 to 20 of about 18,155 (206)

Immunogenicity of HIV-1 Vaccines Expressing Chimeric Envelope Glycoproteins on the Surface of Pr55 Gag Virus-Like Particles

Vaccines, 2020
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral
Rosamund Chapman, Michiel van Diepen, Shireen Galant, Elizabeth Kruse, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny Moore, Nicola Douglass, Anna-Lise Williamson, Edward Rybicki   +10 more
doaj   +1 more source

Immune Suppressive Extracellular Vesicle Proteins of Leptopilina heterotoma Are Encoded in the Wasp Genome

G3: Genes, Genomes, Genetics, 2020
Leptopilina heterotoma are obligate parasitoid wasps that develop in the body of their Drosophila hosts. During oviposition, female wasps introduce venom into the larval hosts’ body cavity.
Brian Wey, Mary Ellen Heavner, Kameron T. Wittmeyer, Thomas Briese, Keith R. Hopper, Shubha Govind   +5 more
doaj   +1 more source

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Viruses, 2019
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes.
Maria Malm, Timo Vesikari, Vesna Blazevic   +2 more
doaj   +1 more source

Quality Assessment of Virus-Like Particles at Single Particle Level: A Comparative Study

Viruses, 2020
Virus-like particles (VLPs) have emerged as a powerful scaffold for antigen presentation and delivery strategies. Compared to single protein-based therapeutics, quality assessment requires a higher degree of refinement due to the structure of VLPs and ...
Irene González-Domínguez, Eduard Puente-Massaguer, Laura Cervera, Francesc Gòdia   +3 more
doaj   +1 more source

Vaccination with virus-like particles containing hemagglutinin protects the lungs of mice with postifluenza bacterial pneumonia: virological, microbiological and clinical data

Вопросы вирусологии, 2020
Introduction. Influenza is a severe viral disease, a frequent complication of which is a secondary bacterial pneumonia. Influenza vaccines prevent secondary bacterial complications.
I. N. Falynskova, A. Yu. Egorov, A. V. Poddubikov, N. O. Vartanova, N. P. Kartashova, E. A. Glubokova, V. A. Mkhitarov, D. S. Dzhalilova, O. V. Makarova, I. A. Leneva   +9 more
doaj   +1 more source

Superior neutralizing antibody response and protection in mice vaccinated with heterologous DNA prime and virus like particle boost against HPAI H5N1 virus. [PDF]

PLoS ONE, 2011
BACKGROUND: Although DNA plasmid and virus-like particle (VLP) vaccines have been individually tested against highly pathogenic avian influenza (HPAI) H5N1 viruses, the combination of both vaccines into a heterologous prime-boost strategy against HPAI ...
Heng Ding, Cheguo Tsai, Ramona Alikiiteaga Gutiérrez, Fan Zhou, Philippe Buchy, Vincent Deubel, Paul Zhou   +6 more
doaj   +1 more source

Dry Formulation of Virus-Like Particles in Electrospun Nanofibers

Vaccines, 2021
Biologics can be combined with liquid polymer materials and electrospun to produce a dry nanofibrous scaffold. Unlike spray-drying and freeze-drying, electrospinning minimizes the physiological stress on sensitive materials, and nanofiber mat properties ...
Sasheen Dowlath, Katrin Campbell, Farah Al-Barwani, Vivienne L. Young, Sarah L. Young, Greg F. Walker, Vernon K. Ward   +6 more
doaj   +1 more source

The safety of attenuated and recombinant nasal influenza vaccines in terms of the development of secondary bacterial superinfection

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Introduction. Influenza is a severe viral disease. The most common post-influenza complication is pneumonia. Earlier, we developed an experimental mouse model of viralbacterial pneumonia induced by successive infection with influenza virus and St. aureus,
N. R. Makhmudova, I. A. Leneva, N. V. Larionova, A. V. Poddubikov, I. N. Falynskova, N. P. Kartashova, O. A. Svitich   +6 more
doaj   +1 more source

Pigs Immunized with the Virus-like Particle Vaccine Are Protected against the Hepatitis E-3 Virus

Vaccines, 2021
In this study, we generated the HEV virus-like particle (VLP) vaccine expressing 239 amino acids (367–605 aa) of the HEV-3 ORF2 using the baculovirus expression system.
Hyeon-Jeong Go, Byung-Joo Park, Hee-Seop Ahn, Dong-Hwi Kim, Da-Yoon Kim, Jae-Hyeong Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Yang-Kyu Choi, In-Soo Choi   +11 more
doaj   +1 more source

Promotion of Cellular and Humoral Immunity against Foot-and-Mouth Disease Virus by Immunization with Virus-Like Particles Encapsulated in Monophosphoryl Lipid A and Liposomes

Vaccines, 2020
Virus-like particles (VLPs) have emerged as promising vaccine candidates against foot-and-mouth disease (FMD). However, such vaccines provide a relatively low level of protection against FMD virus (FMDV) because of their poor immunogenicity.
Woo Sik Kim, Yong Zhi, Huichen Guo, Eui-Baek Byun, Jae Hyang Lim, Ho Seong Seo   +5 more
doaj   +1 more source