Results 11 to 20 of about 25,779 (213)

Establishment of a yeast-based VLP platform for antigen presentation [PDF]

Microbial Cell Factories, 2018
Background Chimeric virus-like particles (VLP) allow the display of foreign antigens on their surface and have proved valuable in the development of safe subunit vaccines or drug delivery.
David Wetzel, Theresa Rolf, Manfred Suckow, Andreas Kranz, Andreas Barbian, Jo-Anne Chan, Joachim Leitsch, Michael Weniger, Volker Jenzelewski, Betty Kouskousis, Catherine Palmer, James G. Beeson, Gerhard Schembecker, Juliane Merz, Michael Piontek   +14 more
doaj   +2 more sources

dreamingpug/VLP: VLP modeling codes

, 2022
All codes created to model and screen VLP candidates with potential for pH-dependant ...
dreamingpug
core   +1 more source

Designing a therapeutic hepatitis B vaccine to circumvent immune tolerance

Human Vaccines & Immunotherapeutics, 2020
An effective prophylactic hepatitis B virus (HBV) vaccine has long been available but is ineffective for chronic infection. The primary cause of chronic hepatitis B (CHB) and greatest impediment for a therapeutic vaccine is the direct and indirect ...
DC Whitacre, CJ Peters, C Sureau, K Nio, F Li, L Su, JE Jones, M Isogawa, M Sallberg, L Frelin, DL Peterson, DR Milich   +11 more
doaj   +1 more source

VLP-RBD vaccine induces high-titer antibody responses in mice.

, 2021
Mice were immunized with RBD, VLP-RBD-M (VLP was prepared from mammalian cells), VLP-RBD-E (VLP was prepared from bacterial cells), or PBS. Mouse sera were collected on day 10 post-2nd immunization for detection of RBD-specific antibodies (A) and spike ...
Jian Shang (1358481), Xiujuan Zhang (174319), Fang Li (41162), Sharon A. Taft-Benz (11402321), Chien-Te K. Tseng (492742), Marc Jenkins (11402327), Wanbo Tai (6535757), Elizabeth J. Anderson (7894313), Ralph S. Baric (7408220), Lanying Du (290113), Qibin Geng (3850708), Aleksandra Drelich (9143151), Victoria K. Baxter (11402318), Audrey C. Knight (11402324), Juan Shi (122591), Sarah R. Leist (7037384), Stephanie A. Montgomery (5797922), Kenneth H. Dinnon III (6482825), Mark Heise (67117), Sung-Wook Hong (592268), Yushun Wan (8551200)   +20 more
core   +1 more source

VLP-RBD vaccine protects mice from SARS-CoV-2 infection in vivo.

, 2021
Mice were immunized with VLP-RBD vaccine, RBD vaccine or PBS, and were then intranasally challenged with a mouse-adapted SARS-CoV-2 strain. Clinical scores (A), body weights (B), and virus titers in the lung tissue (C) of mice were recorded. The data are
Jian Shang (1358481), Xiujuan Zhang (174319), Fang Li (41162), Sharon A. Taft-Benz (11402321), Chien-Te K. Tseng (492742), Marc Jenkins (11402327), Wanbo Tai (6535757), Elizabeth J. Anderson (7894313), Ralph S. Baric (7408220), Lanying Du (290113), Qibin Geng (3850708), Aleksandra Drelich (9143151), Victoria K. Baxter (11402318), Audrey C. Knight (11402324), Juan Shi (122591), Sarah R. Leist (7037384), Stephanie A. Montgomery (5797922), Kenneth H. Dinnon III (6482825), Mark Heise (67117), Sung-Wook Hong (592268), Yushun Wan (8551200)   +20 more
core   +1 more source

Immunogenicity of HIV-1 Vaccines Expressing Chimeric Envelope Glycoproteins on the Surface of Pr55 Gag Virus-Like Particles

Vaccines, 2020
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral
Rosamund Chapman, Michiel van Diepen, Shireen Galant, Elizabeth Kruse, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny Moore, Nicola Douglass, Anna-Lise Williamson, Edward Rybicki   +10 more
doaj   +1 more source

Immune Suppressive Extracellular Vesicle Proteins of Leptopilina heterotoma Are Encoded in the Wasp Genome

G3: Genes, Genomes, Genetics, 2020
Leptopilina heterotoma are obligate parasitoid wasps that develop in the body of their Drosophila hosts. During oviposition, female wasps introduce venom into the larval hosts’ body cavity.
Brian Wey, Mary Ellen Heavner, Kameron T. Wittmeyer, Thomas Briese, Keith R. Hopper, Shubha Govind   +5 more
doaj   +1 more source

Preparation of VLP nanoparticle, SARS-CoV-2 RBD, and VLP-based SARS-CoV-2 RBD vaccine.

, 2021
VLP nanoparticle (A), Fc-tagged SARS-CoV-2 RBD (B), and VLP-RBD complex (C) were each purified to high homogeneity. Left: representative elution profiles of the three proteins from Superose 6 Increase 10/300 GL high-resolution gel filtration ...
Jian Shang (1358481), Xiujuan Zhang (174319), Fang Li (41162), Sharon A. Taft-Benz (11402321), Chien-Te K. Tseng (492742), Marc Jenkins (11402327), Wanbo Tai (6535757), Elizabeth J. Anderson (7894313), Ralph S. Baric (7408220), Lanying Du (290113), Qibin Geng (3850708), Aleksandra Drelich (9143151), Victoria K. Baxter (11402318), Audrey C. Knight (11402324), Juan Shi (122591), Sarah R. Leist (7037384), Stephanie A. Montgomery (5797922), Kenneth H. Dinnon III (6482825), Mark Heise (67117), Sung-Wook Hong (592268), Yushun Wan (8551200)   +20 more
core   +1 more source

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Viruses, 2019
Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes.
Maria Malm, Timo Vesikari, Vesna Blazevic   +2 more
doaj   +1 more source

Quality Assessment of Virus-Like Particles at Single Particle Level: A Comparative Study

Viruses, 2020
Virus-like particles (VLPs) have emerged as a powerful scaffold for antigen presentation and delivery strategies. Compared to single protein-based therapeutics, quality assessment requires a higher degree of refinement due to the structure of VLPs and ...
Irene González-Domínguez, Eduard Puente-Massaguer, Laura Cervera, Francesc Gòdia   +3 more
doaj   +1 more source