Results 21 to 30 of about 18,155 (206)

Transdermal Vaccination with the Matrix-2 Protein Virus-like Particle (M2e VLP) Induces Immunity in Mice against Influenza A Virus

Vaccines, 2021
In this study, our goal was to utilize the extracellular domain matrix-2 protein virus-like particle (M2e VLP) that has been found to be highly conserved amongst all strains of influenza and could serve as a potential vaccine candidate against influenza.
Kimberly Braz Gomes, Sucheta D’Sa, Grace Lovia Allotey-Babington, Sang-Moo Kang, Martin J. D’Souza   +4 more
doaj   +1 more source

Virus-Like Particles and Nanoparticles for Vaccine Development against HCMV

Viruses, 2019
Human cytomegalovirus (HCMV) infects more than 70% of the human population worldwide. HCMV is responsible for high morbidity and mortality in immunocompromised patients and remains the leading viral cause of congenital birth defects. Despite considerable
Michela Perotti, Laurent Perez
doaj   +1 more source

Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery

Viruses, 2022
In this study, we demonstrate how encapsulating a conserved influenza ectodomain matrix-2 protein virus-like particle (M2e5x VLP) into a pre-crosslinked bovine serum albumin (BSA) polymeric matrix enhances in vitro antigen immunogenicity and in vivo ...
Keegan Braz Gomes, Ipshita Menon, Priyal Bagwe, Lotika Bajaj, Sang-Moo Kang, Martin J. D’Souza   +5 more
doaj   +1 more source

RNA: packaged and protected by VLPs

RSC Advances, 2018
VLP packaging is most efficient for compact RNA, and protects RNA against assault by small diffusible damaging agents.
Po-Yu Fang, Jessica C. Bowman, Lizzette M. Gómez Ramos, Chiaolong Hsiao, Loren Dean Williams   +4 more
openaire   +3 more sources

VLPs of Leptopilina boulardi share biogenesis and overall stellate morphology with VLPs of the heterotoma clade [PDF]

Virus Research, 2011
Viruses and virus-like particles (VLPs) of insect parasitoids modify host-parasite interactions. The Drosophila wasp, Leptopilina heterotoma, produce 300 nm spiked VLPs that bind to the host's blood cells via surface projections. L. heterotoma is a generalist wasp that attacks over a dozen Drosophila species.
Gwenaelle, Gueguen, Roma, Rajwani, Indira, Paddibhatla, Jorge, Morales, Shubha, Govind   +4 more
openaire   +2 more sources

Safety and immunogenicity of VLPCOV-02, a SARS-CoV-2 self-amplifying RNA vaccine with a modified base, 5-methylcytosine

iScience
Summary: Continuing emergence of variants of concern resulting in reduced SARS-CoV-2 vaccine efficacy necessitates additional prevention strategies. The structure of VLPCOV-01, a lipid nanoparticle-encapsulated, self-amplifying RNA COVID-19 vaccine with ...
Masayuki Aboshi, Kenta Matsuda, Daisuke Kawakami, Kaoru Kono, Yoko Kazami, Takashi Sekida, Mai Komori, Amber L. Morey, Shigeru Suga, Jonathan F. Smith, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Nobuaki Sato, Wataru Akahata   +14 more
doaj   +1 more source

VLPs and particle strategies for cancer vaccines [PDF]

Expert Review of Vaccines, 2013
Effective delivery of tumor antigens to APCs is one of the key steps for eliciting a strong and durable immune response to tumors. Several cancer vaccines have been evaluated in clinical trials, based on soluble peptides, but results have not been fully satisfactory.
UNGARO, FRANCESCA, CONTE, CLAUDIA, QUAGLIA, FABIANA, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro   +5 more
openaire   +4 more sources

A study of the safety and immunogenicity of a new vaccine for the prevention of COVID-19 based on virus-like particles in phase I clinical trials

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. One of the more promising developments in preventing the spread of infections, including COVID-19, is the production of vaccines based on virus-like particles (VLP).
Tatiana V. Grebennikova, Olga N. Zaykova, Alexey A. Plotnikov, Lyudmila V. Kostina, Yana Yu. Chernoryzh, Olesia V. Eliseeva, Oleg E. Latyshev, Viktor F. Larichev, Irina T. Fedyakina, Milana A. Losich, Ilya M. Kirillov, Ilya E. Filatov, Marina V. Balandina, Valery V. Tsibezov, Kirill I. Yurlov, Ekaterina I. Lesnova, Valeria M. Kondratieva, Alina A. Kozlova, Marina S. Baranets, Aleksandr L. Gintsburg   +19 more
doaj   +1 more source

Generation and immunogenicity assessment of ELPylated virus-like particles of porcine circovirus type 2

Virology Journal, 2020
Background Porcine circovirus type 2 (PCV2) is an economically important pathogen affecting swine industry worldwide. The production of current PCV2 vaccines is time-consuming and expensive.
Yangyang Li, Yajie Wang, Jian Cheng, Xiaohui Zhou, Huipeng Lu, Xinyu Zhang, Xiaoli Xia, Huaichang Sun   +7 more
doaj   +1 more source

Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice

Virus Research, 2023
Background: Human metapneumovirus (HMPV) causes respiratory tract infections among infant, elderly, and immunocompromised patients, with significant mortality. Currently no licensed vaccines or therapeutic agents of HMPV exist.
Fenlian Ma, Aijun Chen, Lihong Yao, Hanchun Gao, Qian Zhang, Wenzhe Hou, Lishu Zheng   +6 more
doaj   +1 more source