Results 121 to 130 of about 10,634 (223)

Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics

, 2001
Mg2+ and ketamine interact superadditively at N- methyl-D-aspartate (NMDA) receptors, which may explain the clinical efficacy of the combination. Because patients are usually exposed concomitantly to volatile anesthetics, we tested the hypothesis that ...
Hollmann, M. W., Hoenemann, C. W., Durieux, M. E., Liu, W. H., Liu, H. T.   +4 more
core  

Structure Elucidation and Total Synthesis of Granolides A–C: Ethyl‐branched Sesquiterpenes From the Tropical Frog Gephyromantis granulatus

Chemistry – A European Journal, Volume 32, Issue 25, 2 July 2026.
Males of the tropical frog Gephyromantis granulatus carry unique ethyl‐branched sesquiterpenoid macrolactones in their scent glands. Their structure elucidation was performed by GC/MS, leading to the proposed structures of the granolides. A flexible enantioselective synthesis confirmed the structures and allowed determination of their absolute ...
Johanna Kuhn, Miguel Vences, Stefan Schulz   +2 more
wiley   +1 more source

Targeted Versus Continuous Delivery of Volatile Anesthetics During Cholinergic Bronchoconstriction

, 2018
Volatile anesthetics have been shown to reduce lung resistance through dilation of constricted airways. In this study, we hypothesized that diffusion of inhaled anesthetics from airway lumen to smooth muscle would yield significant bronchodilation in ...
Brett A. Simon, John S. McNeil, Jacob Herrmann, David W. Kaczka, Jarred R. Mondoñedo   +4 more
core   +1 more source

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel, Andre Dallmann, Ibrahim Ince, Michaela Meyer, Jan‐Frederik Schlender, Donato Teutonico, Erik Sjögren   +6 more
wiley   +1 more source

Antagonism of propofol anesthesia by alkyl-fluorobenzene derivatives

Scientific Reports
Despite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated analogue of propofol has previously been shown to antagonize propofol anesthesia in tadpoles and ...
Diana M. Plasencia, Liam H. Rodgers, Alexys R. Knighton, Roderic G. Eckenhoff, E. Railey White   +4 more
doaj   +1 more source

Trade‐offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress

Functional Ecology, Volume 40, Issue 7, Page 1994-2010, July 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Balancing survival and reproduction presents a fundamental evolutionary challenge, especially in extreme and unpredictable environments. Thermoregulatory behaviour, in particular, imposes a costly trade‐off, as time spent maintaining optimal body temperature precludes ...
David L. Hubert, Ehren J. Bentz, Robert T. Mason   +2 more
wiley   +1 more source

Malignant Hyperthermia in Sweden: Clinical Presentations and Genetic Findings

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Introduction Malignant hyperthermia (MH) is a pharmacogenetic, hypermetabolic and potentially lethal reaction to potent volatile anaesthetics and the muscle relaxant succinylcholine. To improve the understanding of MH, the aim of this retrospective study was to describe the Swedish cohort with respect to clinical manifestations, demographics ...
Anna Hellblom, Maria Soller, Carolina Samuelsson   +2 more
wiley   +1 more source

Volatile general anesthetics enhance desensitization of GABA receptor-Cl^- channel complex

, 1999
Effects of volatile general anesthetics, halothane, isoflurane and enflurane, on γ-aminobutyric acid (GABA)-induced Cl^- current of rat dorsal root ganglion neurons in primary culture were studied by the whole-cell patch-clamp technique. Bath application
Nakahiro, Masanobu, ナカヒロ, マサノブ, 中広, 全延   +2 more
core   +1 more source

An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin. [PDF]

Pharmaceuticals (Basel), 2023
Truglia B, Carbone N, Ghadre I, Vallero S, Zito M, Zizzi EA, Deriu MA, Tuszynski JA.   +7 more
europepmc   +1 more source

Health, Social and Recidivism Outcomes Among People Who Have Been Incarcerated in New South Wales, Australia: Study Protocol and Cohort Profile for the Prison Outcomes STudy (POST)

Drug and Alcohol Review, Volume 45, Issue 5, July 2026.
ABSTRACT Introduction We have been funded to examine post‐incarceration health and social outcomes for all people incarcerated in New South Wales, Australia, 2000–2022; assess treatment and services for drug dependence and serious mental illness; and project the impact of expanding intervention coverage. We will use a linked cohort, the Prison Outcomes
Louisa Degenhardt, Michael Farrell, Michael Doyle, Jack Stone, Chrianna Bharat, Matt Hickman, Marianne Martinello, Don Weatherburn, Kimberlie Dean, Joe Coyte, Christel Macdonald, Mary Ellen Harrod, Luke Grant, Gloria Larman, Peter Vickerman, Colette McGrath, Peter Thompson, Alison Churchill, Greg Dore, Thomas Santo Jr   +19 more
wiley   +1 more source