Results 121 to 130 of about 314,110 (197)

Antagonism of propofol anesthesia by alkyl-fluorobenzene derivatives

Scientific Reports
Despite their frequent use across many clinical settings, general anesthetics are medications with lethal side effects and no reversal agents. A fluorinated analogue of propofol has previously been shown to antagonize propofol anesthesia in tadpoles and ...
Diana M. Plasencia, Liam H. Rodgers, Alexys R. Knighton, Roderic G. Eckenhoff, E. Railey White   +4 more
doaj   +1 more source

Correlating Pulmonary Hemodynamics With HP 129Xe Dissolved‐Phase MRSI in a Controlled Porcine Intervention Study

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2588-2600, December 2026.
ABSTRACT Purpose Pulmonary hypertension is related to a 1‐year mortality ranging from < 5% to > 20% in low‐ and high‐risk groups. Right heart catheterization is the diagnostic gold standard, associated with a 1.1% rate of severe adverse events, posing the need for a non‐invasive diagnostic tool.
Markus Phillip Andersen, Mattias Hedegaard Kristensen, Esben Søvsø Szocska Hansen, Rolf F. Schulte, Mohsen Redda, Uffe Kjærgaard, Michael Vaeggemose, Christoffer Laustsen   +7 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin. [PDF]

Pharmaceuticals (Basel), 2023
Truglia B, Carbone N, Ghadre I, Vallero S, Zito M, Zizzi EA, Deriu MA, Tuszynski JA.   +7 more
europepmc   +1 more source

A Pilot and Feasibility Study of a Four‐Stage Neurological Staging Framework in Pediatric Tracheal Extubation During Anesthesia Emergence

Pediatric Anesthesia, Volume 36, Issue 11, Page 1409-1416, November 2026.
ABSTRACT Background Postoperative tracheal extubation is a particularly high‐risk period in pediatric anesthesia. Because emergence from anesthesia is a complex and complicated process, determining the optimal timing for safe tracheal extubation remains challenging.
Megumi Okuyama, Katsuhiko Ishibashi, Shiori Nakao, Tomoharu Ukiya, Kohei Takahashi, Taiki Kojima   +5 more
wiley   +1 more source

Effects of Esketamine on Emergence Delirium in Children Undergoing Sevoflurane Anesthesia: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 11, Page 1361-1374, November 2026.
ABSTRACT Background Emergence delirium is a frequent and distressing postoperative complication in children, particularly following sevoflurane‐based anesthesia. Despite its clinical importance, the optimal preventive strategy remains under investigation.
Munder Lateiresh, Abdelaziz Louat, Mukhtar Alwefati, Alhasan Altayf, Matthieu Legrand, Phillip D. Cohen, Eman Abdulwahed, Sapna R. Kudchadkar, Muhammed Elhadi   +8 more
wiley   +1 more source

Pre‐Extubation Low‐Dose Propofol in Pediatric Ear, Nose, and Throat Procedures: A Meta‐Analysis With Trial Sequential Analysis

Pediatric Anesthesia, Volume 36, Issue 11, Page 1375-1386, November 2026.
ABSTRACT Background Post‐extubation emergence agitation (EA) is common in pediatric ear, nose, and throat (ENT) procedures and may lead to serious complications. Aims To assess the efficacy of low‐dose propofol administered before extubation, compared with placebo, for preventing EA, using meta‐analysis with trial sequential analysis (TSA).
Rafaela Silva, Raphaela Mendes, João Mario Borges, Henrique Pivetta, Rafael Miranda, Isabela Alles, Vinicius Oliveira, Steven Staffa, Walid Alrayashi   +8 more
wiley   +1 more source

Volatile anesthetics as a neuroprotective agent [PDF]

Korean Journal of Anesthesiology, 2011
Sungsik Park
doaj   +1 more source

Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons. [PDF]

Neuropharmacology, 2023
Speigel I, Patel K, Osman V, Hemmings HC.   +3 more
europepmc   +1 more source

A Sedation Protocol for Endoscopic Baton‐Plate Adjustment in Neonates With Pierre Robin Sequence

Pediatric Anesthesia, Volume 36, Issue 11, Page 1449-1457, November 2026.
ABSTRACT Background Robin sequence (RS) is characterized by upper airway obstruction leading to life‐threatening desaturations in neonates. Procedural sedation in this population presents unique challenges due to anatomical airway anomalies, young patient age, and associated comorbidities.
Nicolas Leister, Sarah Achterrath, Uwe Trieschmann, Teresa Kruse, Bert Braumann, Volker C. Schick   +5 more
wiley   +1 more source