Results 161 to 170 of about 694,198 (334)

Cardiac‐specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility

open access: yesExperimental Physiology, EarlyView.
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Kelsey Halvorson   +11 more
wiley   +1 more source

Sex‐specific differences in mortality and neurocardiac interactions in the Kv1.1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP)

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The Kcna1 knockout mouse model of sudden unexpected death in epilepsy (SUDEP) exhibits sex‐specific differences in SUDEP risk. Female mice exhibit a lower SUDEP risk than males, despite similar seizure characteristics and interictal cardiac function across sexes.
Kelsey Paulhus   +11 more
wiley   +1 more source

Propofol-Based Anesthesia Maintenance and/or Volatile Anesthetics during Intracranial Aneurysm Repair: A Comparative Analysis of Neurological Outcomes. [PDF]

open access: yesJ Clin Med, 2023
Esmaeeli S   +13 more
europepmc   +1 more source

Synergistic roles of aquaporin 5 and intra‐ and extracellular carbonic anhydrases in promoting CO2 diffusion across the Xenopus oocyte plasma membrane

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Fick's law: JCO2=PM*,CO2±hAQP5·([CO2]os±bCA−[CO2]is±hCAII)TransmembraneCO2gradient${J}_{{\mathrm{CO}}_{2}}=\underset{\pm \mathrm{hAQP}5}{\underset{}{{P}_{\mathrm{M}^\ast ,{\mathrm{CO}}_{2}}}}\, \cdot \underset{\mathrm{Transmembrane}\ {\mathrm{CO}}_{2}\ \mathrm{gradient}}{\underset{}{(\underset{\pm \mathrm{bCA}}{\underset ...
Deng‐Ke Wang   +2 more
wiley   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang   +4 more
wiley   +1 more source

An observational laboratory study to evaluate an anesthetic gas adsorber without anesthetic gas scavenging system

open access: yesBMC Anesthesiology
Background Volatile anesthetics are known to be potent greenhouse gases and a significant source of per-and polyfluoroalkyl substances (PFAS) “forever chemical” pollution.
Katja Nickel   +8 more
doaj   +1 more source

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