Results 71 to 80 of about 19,754 (301)

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

open access: yesAdvanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong   +12 more
wiley   +1 more source

Inhaled Volatiles for Status Asthmaticus, Epilepsy, and Difficult Sedation in Adult ICU and PICU: A Systematic Review

open access: yesCritical Care Explorations
OBJECTIVES:. Inhaled volatile anesthetics support management of status asthmaticus (SA), status epilepticus (SE), and difficult sedation (DS). This study aimed to evaluate the effectiveness, safety, and feasibility of using inhaled anesthetics for SA, SE,
Kevin Gorsky, MD   +83 more
doaj   +1 more source

Isoflurane cracks the polycarbonate connector of extra-corporeal circuit -A case report- [PDF]

open access: yesKorean Journal of Anesthesiology, 2010
Cardiopulmonary bypass (CPB) is widely used for cardiac surgery by virtue of its proven safety over the course of its use during the past half century. Even though perfusion is safer, incidents still occur.
Hyung Sun Lim   +4 more
doaj   +1 more source

Research advances in dysphagia animal models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai   +5 more
wiley   +1 more source

Effects of Inhalation versus Total Intravenous Anesthesia on Postoperative Pulmonary Complications after Anatomic Pulmonary Resection

open access: yesJournal of Chest Surgery, 2022
Background: No consensus exists regarding whether volatile anesthetics are superior to intravenous anesthetics for reducing postoperative pulmonary complications (PPCs) in patients undergoing general anesthesia for surgery.
Soojin Lee   +4 more
doaj   +1 more source

Enhanced charge-independent Mitochondrial Free Ca\u3csup\u3e2+\u3c/sup\u3e and Attenuated ADP-induced NADH Oxidation by Isoflurane: Implications for Cardioprotection [PDF]

open access: yes, 2012
Modulation of mitochondrial free Ca2 + ([Ca2 +]m) is implicated as one of the possible upstream factors that initiates anesthetic-mediated cardioprotection against ischemia–reperfusion (IR) injury.
Agarwal, Bhawana   +4 more
core   +1 more source

Critical Changes in Cortical Neuronal Interactions in Anesthetized and Awake Rats [PDF]

open access: yes, 2015
Background: Neuronal interactions are fundamental for information processing, cognition and consciousness. Anesthetics reduce spontaneous cortical activity; however, neuronal reactivity to sensory stimuli is often preserved or augmented.
Hudetz, Anthony G.   +3 more
core   +2 more sources

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

open access: yesChemistry &Biodiversity, EarlyView.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni   +5 more
wiley   +1 more source

Local anaesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro

open access: yes, 2016
Retrospective studies indicate that the use of regional anesthesia can reduce cancer recurrence after surgery which could be due to ranging from immune function preservation to direct molecular mechanisms.
Chen, L   +5 more
core   +3 more sources

Home - About - Disclaimer - Privacy