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Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2.

Biochemical and Biophysical Research Communications - BBRC, 2018
Sulindac sulfone is a metabolite of sulindac, a non-steroidal anti-inflammatory drug (NSAID), without anti-inflammatory ability. However, sulindac sulfone has been reported to significantly reduce polyps in patients with colorectal adenomatous polyposis ...
Y. Aono   +6 more
semanticscholar   +1 more source

Endosomes: another extra-mitochondrial location of type-1 porin/voltage-dependent anion-selective channels (VDAC)

Pfl�gers Archiv European Journal of Physiology, 1998
Endocytotic vesicles (EV) isolated from rat renal cortex were subjected to SDS-polyacrylamide gel electrophoresis and Western blotting. A monoclonal antibody against human type-1 porin (31 kDa) detected a strong band of 31 kDa. The same antibody has been used as the primary antibody in indirect immunocytochemistry. Light microscopy of cryostat sections
Reymann, S.   +4 more
openaire   +3 more sources

Microglial voltage-dependent anion channel 1 signaling modulates sleep deprivation-induced transition to chronic postsurgical pain

SLEEP, 2023
AbstractStudy ObjectivesThis study verified that sleep deprivation before and after skin/muscle incision and retraction (SMIR) surgery increased the risk of chronic pain and investigated the underlying roles of microglial voltage-dependent anion channel 1 (VDAC1) signaling.MethodsAdult mice received 6 hours of total sleep deprivation from 1 day prior ...
Shi-Nan, Wei   +11 more
openaire   +2 more sources

LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1

Cell Biology and Toxicology, 2021
Shangjie Liu   +8 more
semanticscholar   +1 more source

Hypothermia‐induced increase of oligodendrocyte precursor cells: Possible involvement of plasmalemmal voltage‐dependent anion channel 1

Journal of Neuroscience Research, 2010
AbstractHypothermia is believed to suppress cell proliferation by inducing apoptosis/necrosis and phase‐specific/nonspecific cell cycle arrest, which are, directly or indirectly, related to a reduced energy supply. Intriguingly, hypothermia is known to improve neurological recovery of animals and humans exposed to focal brain hypoxic‐ischemic injury ...
Shinya, Imada   +8 more
openaire   +2 more sources

Identification of voltage-dependent anion-selective channel protein 1 as a freezability biomarker in chicken spermatozoa

International Journal of Biological Macromolecules
The sperm freezability during cryopreservation varies widely in chicken breeds and individuals, however, the underlying mechanisms are especially less examined. Comparative 4D label-free quantitative proteomic analysis of four high-freezability (HF) and four low-freezability (LF) Beijing-You chickens identified 42 differentially expressed proteins ...
Yunhe, Zong   +8 more
openaire   +2 more sources

Advances in TRP channel drug discovery: from target validation to clinical studies

Nature Reviews Drug Discovery, 2021
Ari-Pekka Koivisto   +2 more
exaly  

Pushing the limit of 3d transition metal-based layered oxides that use both cation and anion redox for energy storage

Nature Reviews Materials, 2022
Minghao Zhang   +2 more
exaly  

Anion-Exchange Membrane Water Electrolyzers

Chemical Reviews, 2022
Claudie Roy   +2 more
exaly  

Pseudo-halide anion engineering for α-FAPbI3 perovskite solar cells

Nature, 2021
Jaeki Jeong, Jongdeuk Seo, Haizhou Lu
exaly  

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