Results 1 to 10 of about 9,741 (137)

Signaling pathways regulating VDAC1 overexpression associated with apoptosis, pyroptosis, and ferroptosis [PDF]

Cell Communication and Signaling
Mitochondrial VDAC1 is a multi-functional protein that acts as a convergence point for various cell survival and death signals. Under stress and pathological conditions, VDAC1 is overexpressed.
Aditya Karunanithi Nivedita, Manikandan Santhanam, Venkatadri Babu, Anna Shteinfer-Kuzmine, Alfredo Garcia Venzor, Debra Toiber, Varda Shoshan-Barmatz   +6 more
doaj   +2 more sources

Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities

Cells, 2022
The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to power cellular bioactivities via energy generation. VDAC1 is involved
Linlin Guo
exaly   +3 more sources

Elliptical β-barrel deformation underlies gating in VDAC1. [PDF]

Protein Sci
Abstract Gating by voltage‐dependent anion channels (VDAC) regulates mitochondrial metabolite flux, yet the structural mechanism underlying the open‐to‐closed transition remains unresolved. Here, we combine atomistic molecular dynamics (MD) simulations with double electron–electron resonance (DEER), using hydrostatic pressure as a reversible ...
Bergdoll L, Elgeti M, Belyaeva J, Zlobin A, Duneau JP, Hubbell W, Abramson J.   +6 more
europepmc   +2 more sources

p53 Interacts with VDAC1, Modulating Its Expression Level and Oligomeric State to Activate Apoptosis [PDF]

Biomolecules
The p53 tumor suppressor, a key transcription factor, acts as a cellular stress sensor that regulates hundreds of genes involved in responses to DNA damage, oxidative stress, and ischemia.
Elinor Gigi, Aditya Karunanithi Nivedita, Danya Ben-Hail, Manikandan Santhanam, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz   +5 more
doaj   +2 more sources

Disrupting VDAC1–tubulin interaction uncovers crosstalk between mitochondrial and microtubule functions with implication to cancer therapy [PDF]

Cellular and Molecular Life Sciences
Tubulin, a key component of the microtubule (MT) cytoskeleton, interacts with the mitochondrial gatekeeper protein VDAC1. Using a peptide array, we identified four VDAC1-binding sites in α-tubulin-1B.
Manikandan Santhanam, Anna Shteinfer-Kuzmine, Omer Bushusha, Ran Zalk, Larisa Gheber, Varda Shoshan-Barmatz   +5 more
doaj   +2 more sources

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear.
Angelique Mularoni, Jean-Guy Delcros, Celine Freton   +2 more
exaly   +3 more sources

HSP90AA1–VDAC1 interaction contributes to breast cancer progression and doxorubicin resistance through PI3K/AKT signaling [PDF]

Breast Cancer Research
Background Chemotherapy resistance remains a major obstacle to durable control of breast cancer (BC), particularly to doxorubicin (DOX). Heat shock protein 90 alpha family class A member 1 (HSP90AA1) and the mitochondrial outer-membrane channel VDAC1 ...
Yutong Fang, Cuiping Guo, Fengtao Zheng, Yefeng Xiao, Junpeng Liu, Yongqu Zhang, Jundong Wu   +6 more
doaj   +2 more sources

DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates in vitro and in vivo RSV infection [PDF]

Journal of Virology
Human respiratory syncytial virus (RSV) is a major pathogen causing acute lower respiratory tract infections in infants, young children, and elderly people worldwide. Viruses often hijack host cell ion channels to optimize their intracellular environment,
Siyu Lin, Xiaotong Chen, Meihua Luo, Xiaolu Cui, You Dai, Zhen Sun, Guikang Wang, Hong Peng, Ping Ling, Jinlin Long, Huifang Zhou, Changlei Luo, Yan-Fei Qi, Ke Zhang, Yu-Si Luo   +14 more
doaj   +2 more sources

Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels

Redox Biology
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Given the critical role of liver in iron storage and metabolism, ferroptosis, characterized by iron-dependent lipid peroxidation and oxidative damage, has become ...
Yaotang Deng, Yaling Huang
exaly   +3 more sources

VDAC1-Based Peptides as Potential Modulators of VDAC1 Interactions with Its Partners and as a Therapeutic for Cancer, NASH, and Diabetes

Biomolecules
This review presents current knowledge related to the voltage-dependent anion channel-1 (VDAC1) as a multi-functional mitochondrial protein that acts in regulating both cell life and death.
Anna Shteinfer-Kuzmine, Manikandan Santhanam, Varda Shoshan-Barmatz   +2 more
exaly   +3 more sources