Results 1 to 10 of about 11,641 (203)

VDAC1-Based Peptides as Potential Modulators of VDAC1 Interactions with Its Partners and as a Therapeutic for Cancer, NASH, and Diabetes

Biomolecules
This review presents current knowledge related to the voltage-dependent anion channel-1 (VDAC1) as a multi-functional mitochondrial protein that acts in regulating both cell life and death.
Varda Shoshan-Barmatz, Manikandan Santhanam, Anna Shteinfer-Kuzmine   +2 more
exaly   +6 more sources

Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels

Redox Biology
Hepatocellular carcinoma (HCC) is one of the most common and lethal malignancies worldwide. Given the critical role of liver in iron storage and metabolism, ferroptosis, characterized by iron-dependent lipid peroxidation and oxidative damage, has become ...
Yaotang Deng, Manfeng Liang, Hairou Su
exaly   +4 more sources

Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities

Cells, 2022
The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to power cellular bioactivities via energy generation. VDAC1 is involved
Linlin Guo, Jay Overholser
exaly   +4 more sources

Senkyunolide I Inhibits mtDNA-cGAS-STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis. [PDF]

Adv Sci (Weinh)
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Ye Z, Huang Y, Han B, Zhang L, Yu C, Yang Y, Liu B, Jian Y, Xu Z, Zeng C.   +9 more
europepmc   +2 more sources

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar-Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps. [PDF]

Adv Sci (Weinh)
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Zhu X, Chen Y, Meng W, Xu B, Mou J, Liu X, Wang M, Gu Q, Sun Q, Li M, Zhao C, Zeng M, Lv Y, Yi B, Qu S, Bai X, Li J, Luo X, Hu S, Yu B, Jia H.   +20 more
europepmc   +2 more sources

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency. [PDF]

Adv Sci (Weinh)
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Yang Q, Jiang H, Xiong C, Zhou X, Tan Q, Xiao H, Qiu L, Gan C, Chen Y, Yang H, Jiang W, Li Q.   +11 more
europepmc   +2 more sources

The compartment-specific interactome of VDAC1 reveals its emerging role beyond mitochondria in breast cancer [PDF]

Scientific Reports
Voltage-dependent anion channel 1 (VDAC1) is a multifunctional protein that is primarily localized in the outer mitochondrial membrane, where it regulates metabolite flux and apoptosis.
Paweł Jóźwiak, Marek Mądrecki, Joanna Oracz, Marcin Jankowski, Kamila Balcerzak, Karolina Anna Kozal, Dorota Żyżelewicz, Anna Krześlak   +7 more
doaj   +2 more sources

Targeting Ero1L by Parthenolide Alleviates Cellular Senescence and Fibrosis of Localized Scleroderma by Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes Stabilization. [PDF]

Aging Cell
PTL inhibits cell senescence and alleviates fibrosis of Los by regulating Ero1L‐mediated mitochondria‐associated endoplasmic reticulum membranes stabilization. ABSTRACT Mitochondrial dysfunction drives scleroderma pathogenesis. The mitochondria‐associated endoplasmic reticulum membrane (MAM) regulates mitochondrial function.
Wang F, Xing R, Xie M, Qin Y, Zhang Y, Cao D, He G, Lyu X.   +7 more
europepmc   +2 more sources

A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization inhibitor [PDF]

eLife
Voltage-dependent anion channel (VDAC) is the most abundant protein of the mitochondrial outer membrane and a key regulator of metabolite exchange and mitochondrial physiology.
Varun Ravishankar, Luís Borges-Araújo, Megha Rajendran, Elodie Lafargue, Deborah Byrne, Nicolas Buzhinsky, Mya S Wolfe, Wendy Fitzgerald, Nina A Bautista, Bethel G Beyene, Motahareh G Larimi, Jean-Pierre Duneau, James Sturgis, Sergey M Bezrukov, Ignacio Casuso, Tatiana K Rostovtseva, Lucie Bergdoll   +16 more
doaj   +2 more sources

Disrupting VDAC1–tubulin interaction uncovers crosstalk between mitochondrial and microtubule functions with implication to cancer therapy [PDF]

Cellular and Molecular Life Sciences
Tubulin, a key component of the microtubule (MT) cytoskeleton, interacts with the mitochondrial gatekeeper protein VDAC1. Using a peptide array, we identified four VDAC1-binding sites in α-tubulin-1B.
Manikandan Santhanam, Anna Shteinfer-Kuzmine, Omer Bushusha, Ran Zalk, Larisa Gheber, Varda Shoshan-Barmatz   +5 more
doaj   +2 more sources