Results 31 to 40 of about 11,641 (203)

IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling [PDF]

, 2022
Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in type 2 diabetes mellitus (T2DM).
Tse, G.
core   +1 more source

VDAC1-based peptide as potential treatment for pathologies of the liver and pancreas

Медицинский совет, 2022
Diseases associated with damage to such vital organs of the digestive system as the liver and pancreas are an urgent problem of world health. Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic; the problem of type 2 diabetes (T2D) mellitus
V. N. Nikolenko, N. A. Rizaeva, A. A. Bolotskaia, K. V. Bulygin   +3 more
doaj   +1 more source

Overexpressed VDAC1 in breast cancer as a novel prognostic biomarker and correlates with immune infiltrates

World Journal of Surgical Oncology, 2022
Background More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis.
Yutong Fang, Junpeng Liu, Qunchen Zhang, Chuanghong She, Rongji Zheng, Rendong Zhang, Zexiao Chen, Chunfa Chen, Jundong Wu   +8 more
doaj   +1 more source

VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway

Cell Death and Disease, 2022
The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of metabolites and ions, thereby integrating both cell survival and death signals.
Erica de Sousa, Marília Inês Móvio, Théo Henrique de Lima-Vasconcellos, Gabrieli Bovi dos Santos, Talita dos Santos Gomes, Lais Takata Walter, Daniela Almeida da Silva, Tiago Rodrigues, Giselle Cerchiaro, Alexandre Hiroaki Kihara   +9 more
doaj   +1 more source

Probing the orientation of yeast VDAC1 in vivo [PDF]

FEBS Letters, 2009
Voltage dependent anion channel (VDAC) is a vital ion channel in mitochondrial outer membranes and its structure was recently shown to be a 19 stranded β‐barrel. However the orientation of VDAC in the membrane remains unclear. We probe here the topology and membrane orientation of yeast Saccharomyces cerevisiae in vivo.
McDonald BM, Wydro MM, Lightowlers RN, Lakey JH   +3 more
openaire   +3 more sources

VDAC1 Is a Transplasma Membrane NADH-Ferricyanide Reductase [PDF]

Journal of Biological Chemistry, 2004
Porin isoform 1 or VDAC (voltage-dependent anion-selective channel) 1 is the predominant protein in the outer mitochondrial membrane. We demonstrated previously that a plasma membrane NADH-ferricyanide reductase activity becomes up-regulated upon mitochondrial perturbation, and therefore suggested that it functions as a cellular redox sensor.
M. A. BAKER, J. D. LY, DE PINTO V, A. LAWEN, LANE DJR   +4 more
openaire   +4 more sources

Inhibition of VDAC1 Rescues Aβ1-42-Induced Mitochondrial Dysfunction and Ferroptosis via Activation of AMPK and Wnt/β-Catenin Pathways

Mediators of Inflammation, 2023
Beta-amyloid (Aβ) accumulation in the brains of Alzheimer’s disease (AD) patients leads to mitochondrial dysfunction and ferroptosis in neurons. Voltage-dependent anion channel 1 (VDAC1) is a major protein in the mitochondrial outer membrane. It has been
Xinpei Zhou, Ximin Tang, Tao Li, Dandan Li, Zhiting Gong, Xiujun Zhang, Yanjiao Li, Jianhua Zhu, Yong Wang, Bensi Zhang   +9 more
doaj   +1 more source

Role of VDAC1 in hepatocyte apoptosis during acute liver injury in rats induced by obstructive jaundice [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Exploring the role of VDAC1 in hepatocyte apoptosis during acute liver injury induced by obstructive jaundice.Materials and Methods: Animal and cell models were established to investigate possible mechanisms during acute liver injury ...
Jinshan Liu, Jinlong Hu, Hongyu Xu, Liang Yan, Jiaming Yao, Baoqiang Cao   +5 more
doaj   +1 more source

VDAC1 Negatively Regulates Floral Transition in Arabidopsis thaliana [PDF]

International Journal of Molecular Sciences, 2021
Voltage-dependent anion channels (VDACs) are the most important proteins in mitochondria. They localize to the outer mitochondrial membrane and contribute to the metabolite transport between the mitochondria and cytoplasm, which aids plant growth regulation.
Jingya Xu, Yuzhen Zhang, Hongjia Ren, Runyi Yu, Chen Yuan, Yikai Hu, Rumeng Xu, Xuming Wang, Cheng Qin   +8 more
openaire   +2 more sources

Hierridin B Isolated from a Marine Cyanobacterium Alters VDAC1, Mitochondrial Activity, and Cell Cycle Genes on HT-29 Colon Adenocarcinoma Cells

Marine Drugs, 2016
Background: Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated. Methods: HT-29 cells were exposed to the
Sara Freitas, Rosário Martins, Margarida Costa, Pedro N. Leão, Rui Vitorino, Vitor Vasconcelos, Ralph Urbatzka   +6 more
doaj   +1 more source