Results 31 to 40 of about 10,788 (194)
Molecular OncologyEtoposide is an inhibitor of DNA topoisomerase II, an enzyme essential for DNA transcription, replication, and chromosome segregation. It is well accepted that etoposide triggers cell death due to DNA damage.
Aditya Karunanithi Nivedita +1 more
doaj +2 more sources
Вавиловский журнал генетики и селекции, 2023 The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. It has been known that nucleic acids enter plant organelles through alternative channels,
T. A. Tarasenko +4 more
doaj +1 more source
VDAC1-based peptide as potential treatment for pathologies of the liver and pancreas
Медицинский совет, 2022 Diseases associated with damage to such vital organs of the digestive system as the liver and pancreas are an urgent problem of world health. Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic; the problem of type 2 diabetes (T2D) mellitus
V. N. Nikolenko +3 more
doaj +1 more source
IP3R1/GRP75/VDAC1 complex mediates endoplasmic reticulum stress-mitochondrial oxidative stress in diabetic atrial remodeling [PDF]
, 2022 Rationale Endoplasmic reticulum (ER) stress and mitochondrial dysfunction are important mechanisms of atrial remodeling, predisposing to the development of atrial fibrillation (AF) in type 2 diabetes mellitus (T2DM).
Tse, G.
core +1 more source
Experimental and Molecular MedicineMetformin (MetF) is used worldwide as a first-line therapy for type 2 diabetes. Recently, interest in the pleiotropic effects of MetF, such as its anticancer and antiaging properties, has increased.
Minjeong Ko +8 more
doaj +2 more sources
World Journal of Surgical Oncology, 2022 Background More and more evidence suggests that cancer is a mitochondrial metabolic disease recently and mitochondria dysfunction is critical to tumorigenesis.
Yutong Fang +8 more
doaj +1 more source
Probing the orientation of yeast VDAC1 in vivo [PDF]
FEBS Letters, 2009 Voltage dependent anion channel (VDAC) is a vital ion channel in mitochondrial outer membranes and its structure was recently shown to be a 19 stranded β‐barrel. However the orientation of VDAC in the membrane remains unclear. We probe here the topology and membrane orientation of yeast Saccharomyces cerevisiae in vivo.
McDonald BM +3 more
openaire +3 more sources
VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway
Cell Death and Disease, 2022 The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of metabolites and ions, thereby integrating both cell survival and death signals.
Erica de Sousa +9 more
doaj +1 more source
VDAC1 Is a Transplasma Membrane NADH-Ferricyanide Reductase [PDF]
Journal of Biological Chemistry, 2004 Porin isoform 1 or VDAC (voltage-dependent anion-selective channel) 1 is the predominant protein in the outer mitochondrial membrane. We demonstrated previously that a plasma membrane NADH-ferricyanide reductase activity becomes up-regulated upon mitochondrial perturbation, and therefore suggested that it functions as a cellular redox sensor.
M. A. BAKER +4 more
openaire +4 more sources
VDAC1 Negatively Regulates Floral Transition in Arabidopsis thaliana [PDF]
International Journal of Molecular Sciences, 2021 Voltage-dependent anion channels (VDACs) are the most important proteins in mitochondria. They localize to the outer mitochondrial membrane and contribute to the metabolite transport between the mitochondria and cytoplasm, which aids plant growth regulation.
Jingya Xu +8 more
openaire +2 more sources