Results 21 to 30 of about 10,788 (194)
VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism [PDF]
Scientific Reports, 2020 The voltage-dependent anion channel 1 (VDAC1) is a key player in mitochondrial function. VDAC1 serves as a gatekeeper mediating the fluxes of ions, nucleotides, and other metabolites across the outer mitochondrial membrane, as well as the release of ...
Hadar Klapper-Goldstein +8 more
doaj +3 more sources
Properties of the permeability transition in VDAC1−/− mitochondria
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Opening of the permeability transition pore (PTP), a high-conductance mitochondrial channel, causes mitochondrial dysfunction with Ca2+ deregulation, ATP depletion, release of pyridine nucleotides and of mitochondrial apoptogenic proteins. Despite major efforts, the molecular nature of the PTP remains elusive.
KRAUSKOPF A +4 more
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Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks
Biomolecules, 2022 Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer.
Swaroop Kumar Pandey +4 more
doaj +2 more sources
VDAC1 (voltage-dependent anion channel 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
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Deletion of VDAC1 Hinders Recovery of Mitochondrial and Renal Functions After Acute Kidney Injury
Biomolecules, 2020 Voltage-dependent anion channels (VDACs) constitute major transporters mediating bidirectional movement of solutes between cytoplasm and mitochondria.
Grazyna Nowak +2 more
doaj +2 more sources
The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2013 The voltage-dependent anion channel (VDAC), located at the outer mitochondria membrane (OMM), mediates interactions between mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca(2+), and metabolites. Substantial evidence points to VDAC1 as being a key player in apoptosis, regulating the release of apoptogenic proteins from ...
Keinan, Nurit +3 more
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Molecular Therapy - Nucleic Acids, 2019 The mitochondrial gatekeeper voltage-dependent anion channel 1 (VDAC1) controls metabolic and energy cross-talk between mitochondria and the rest of the cell and is involved in mitochondria-mediated apoptosis.
Tasleem Arif, Varda Shoshan-Barmatz
exaly +3 more sources
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Molecular Therapy: Nucleic Acids, 2014 Alterations in cellular metabolism and bioenergetics are vital for cancer cell growth and motility. Here, the role of the mitochondrial protein voltage-dependent anion channel (VDAC1), a master gatekeeper regulating the flux of metabolites and ions ...
Tasleem Arif +4 more
doaj +2 more sources
VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration
BiomoleculesVoltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating the exchange of ions and metabolites between mitochondria and the cytosol.
Shirel Argueti-Ostrovsky +3 more
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Molecular Oncology, 2018 Mitochondrial VDAC1 mediates cross talk between the mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+, and metabolites and serves as a key player in apoptosis.
Anna Shteinfer-Kuzmine +2 more
exaly +2 more sources