Results 21 to 30 of about 11,641 (203)
Properties of the Permeability Transition in VDAC1-/- Mitochondria [PDF]
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2006 Opening of the permeability transition pore (PTP), a high-conductance mitochondrial channel, causes mitochondrial dysfunction with Ca2+ deregulation, ATP depletion, release of pyridine nucleotides and of mitochondrial apoptogenic proteins.
FORTE MA +8 more
core +5 more sources
VDAC1 in the diseased myocardium and the effect of VDAC1-interacting compound on atrial fibrosis induced by hyperaldosteronism [PDF]
Scientific Reports, 2020 The voltage-dependent anion channel 1 (VDAC1) is a key player in mitochondrial function. VDAC1 serves as a gatekeeper mediating the fluxes of ions, nucleotides, and other metabolites across the outer mitochondrial membrane, as well as the release of ...
Hadar Klapper-Goldstein +8 more
doaj +3 more sources
VDAC1 selectively transfers apoptotic Ca 2 signals to mitochondria [PDF]
Cell Death & Differentiation, 2012 Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect ...
De Stefani D +6 more
core +8 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear.
Hubert Gorny +5 more
doaj +2 more sources
Silencing VDAC1 to Treat Mesothelioma Cancer: Tumor Reprograming and Altering Tumor Hallmarks
Biomolecules, 2022 Mesothelioma, an aggressive cancer with a poor prognosis, is linked to asbestos exposure. However, carbon nanotubes found in materials we are exposed to daily can cause mesothelioma cancer.
Swaroop Kumar Pandey +4 more
doaj +2 more sources
Deletion of VDAC1 Hinders Recovery of Mitochondrial and Renal Functions After Acute Kidney Injury
Biomolecules, 2020 Voltage-dependent anion channels (VDACs) constitute major transporters mediating bidirectional movement of solutes between cytoplasm and mitochondria.
Grazyna Nowak +2 more
doaj +2 more sources
Molecular Therapy - Nucleic Acids, 2019 The mitochondrial gatekeeper voltage-dependent anion channel 1 (VDAC1) controls metabolic and energy cross-talk between mitochondria and the rest of the cell and is involved in mitochondria-mediated apoptosis.
Tasleem Arif +2 more
exaly +3 more sources
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Molecular Therapy: Nucleic Acids, 2014 Alterations in cellular metabolism and bioenergetics are vital for cancer cell growth and motility. Here, the role of the mitochondrial protein voltage-dependent anion channel (VDAC1), a master gatekeeper regulating the flux of metabolites and ions ...
Tasleem Arif +4 more
doaj +2 more sources
Molecular OncologyEtoposide is an inhibitor of DNA topoisomerase II, an enzyme essential for DNA transcription, replication, and chromosome segregation. It is well accepted that etoposide triggers cell death due to DNA damage.
Aditya Karunanithi Nivedita +1 more
doaj +2 more sources
Вавиловский журнал генетики и селекции, 2023 The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. It has been known that nucleic acids enter plant organelles through alternative channels,
T. A. Tarasenko +4 more
doaj +1 more source