Results 41 to 50 of about 10,788 (194)
Mediators of Inflammation, 2023 Beta-amyloid (Aβ) accumulation in the brains of Alzheimer’s disease (AD) patients leads to mitochondrial dysfunction and ferroptosis in neurons. Voltage-dependent anion channel 1 (VDAC1) is a major protein in the mitochondrial outer membrane. It has been
Xinpei Zhou +9 more
doaj +1 more source
Investigating VDAC1 Orientation In Vivo [PDF]
Biophysical Journal, 2010 VDAC is an important and abundant ion channel in mitochondrial outer membranes but its structure remained unclear until recent structures of human VDAC1 revealed a 19 stranded β-barrel. Nevertheless there are still unresolved questions concerning the orientation of VDAC in the membrane and its fine structure.
Lakey, Jeremy H. +3 more
openaire +1 more source
Cells, 2019 Reprograming of the metabolism of cancer cells is an event recognized as a hallmark of the disease. The mitochondrial gatekeeper, voltage-dependent anion channel 1 (VDAC1), mediates transport of metabolites and ions in and out of mitochondria, and is ...
Tasleem Arif +4 more
doaj +1 more source
Role of VDAC1 in hepatocyte apoptosis during acute liver injury in rats induced by obstructive jaundice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Exploring the role of VDAC1 in hepatocyte apoptosis during acute liver injury induced by obstructive jaundice.Materials and Methods: Animal and cell models were established to investigate possible mechanisms during acute liver injury ...
Jinshan Liu +5 more
doaj +1 more source
Marine Drugs, 2016 Background: Hierridin B was isolated from a marine cyanobacterium Cyanobium sp. strain and induced cytotoxicity selectively in HT-29 adenocarcinoma cells. The underlying molecular mechanism was not yet elucidated. Methods: HT-29 cells were exposed to the
Sara Freitas +6 more
doaj +1 more source
VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection
, 2022 Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infection in insect
Dongsheng Jia (521906) +6 more
core +1 more source
Correlation between ODN and VDAC1 pixel intensity by linear regression.
, 2023 Pixel intensity values for FITC-labeled ODN and Alexa Fluor 555-labeled anti-VDAC1 antibody were plotted against each other and a simple linear regression model was fit to the data.
Philip L. Lorenzi (30988) +14 more
core +1 more source
VDAC1, mitochondrial dysfunction, and Alzheimer's disease
Pharmacological Research, 2018 Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear.
Varda, Shoshan-Barmatz +3 more
openaire +2 more sources
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
doaj +1 more source
Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions
Diagnostics, 2023 Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions ...
Irit Allon +5 more
doaj +1 more source