Results 41 to 50 of about 11,641 (203)
Investigating VDAC1 Orientation In Vivo [PDF]
Biophysical Journal, 2010 VDAC is an important and abundant ion channel in mitochondrial outer membranes but its structure remained unclear until recent structures of human VDAC1 revealed a 19 stranded β-barrel. Nevertheless there are still unresolved questions concerning the orientation of VDAC in the membrane and its fine structure.
Lakey, Jeremy H. +3 more
openaire +1 more source
Cells, 2019 Reprograming of the metabolism of cancer cells is an event recognized as a hallmark of the disease. The mitochondrial gatekeeper, voltage-dependent anion channel 1 (VDAC1), mediates transport of metabolites and ions in and out of mitochondria, and is ...
Tasleem Arif +4 more
doaj +1 more source
VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection
, 2022 Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infection in insect
Dongsheng Jia (521906) +6 more
core +1 more source
Correlation between ODN and VDAC1 pixel intensity by linear regression.
, 2023 Pixel intensity values for FITC-labeled ODN and Alexa Fluor 555-labeled anti-VDAC1 antibody were plotted against each other and a simple linear regression model was fit to the data.
Philip L. Lorenzi (30988) +14 more
core +1 more source
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
doaj +1 more source
Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction [PDF]
, 2014 VDAC1, an outer mitochondrial membrane (OMM) protein, is crucial for regulating mitochondrial metabolic and energetic functions and acts as a convergence point for various cell survival and death signals. VDAC1 is also a key player in apoptosis, involved
Shoshan-Barmatz, Varda +4 more
core +1 more source
VDAC1, mitochondrial dysfunction, and Alzheimer's disease
Pharmacological Research, 2018 Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear.
Varda, Shoshan-Barmatz +3 more
openaire +2 more sources
Is VDAC1 a Novel BCL2 Family Member that Binds BAX? [PDF]
, 2023 Apoptosis is a type of regulated cell death important for normal embryonic development and maintenance of adult tissues by removing excess or dysfunctional cells to ensure proper functioning of organs.
Pearson, Claire
core +1 more source
Visualizing VDAC1 in live cells using a tetracysteine tag.
PLoS ONEThe voltage-dependent anion channel 1 (VDAC1) is a crucial gatekeeper in the outer mitochondrial membrane, controlling metabolic and energy homeostasis. The available methodological approaches fell short of accurate visualization of VDAC1 in living cells.
Johannes Pilic +5 more
doaj +1 more source
Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. [PDF]
PLoS ONE, 2014 Mitochondrial voltage-dependent anion channels (VDACs) play a key role in mitochondria-mediated apoptosis. Both in vivo and in vitro evidences indicate that VDACs are actively involved in tumor progression.
Jae-Hong Ko +4 more
doaj +1 more source