Results 61 to 70 of about 11,641 (203)

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

PB1-F2 Protein Interacts with ANT3 and VDAC1

, 2013
(A) Cellular proteins pulled down with GST-PB1-F2 were separated by 12% SDS-PAGE and silver-stained. The asterisks mark the protein bands that are unique to the GST-PB1-F2 lanes (~36 kDa, 55 kDa, and 80 kDa).
Adolfo García-Sastre (51848), Dmitriy Zamarin (59793), Peter Palese (59796), Xiaoyao Xiao (59794), Rong Wang (59795)   +4 more
core   +1 more source

Signaling pathways regulating VDAC1 overexpression associated with apoptosis, pyroptosis, and ferroptosis

Cell Communication and Signaling
Mitochondrial VDAC1 is a multi-functional protein that acts as a convergence point for various cell survival and death signals. Under stress and pathological conditions, VDAC1 is overexpressed.
Aditya Karunanithi Nivedita, Manikandan Santhanam, Venkatadri Babu, Anna Shteinfer-Kuzmine, Alfredo Garcia Venzor, Debra Toiber, Varda Shoshan-Barmatz   +6 more
doaj   +1 more source

The VDAC1 oligomerization regulated by ATP5B leads to the NLRP3 inflammasome activation in the liver cells under PFOS exposure

Ecotoxicology and Environmental Safety
As a persistent organic pollutant, perfluorooctane sulfonate (PFOS) has a serious detrimental impact on human health. It has been suggested that PFOS is associated with liver inflammation. However, the underlying mechanisms are still unclear.
Yu Ma, Wei Yang, Peiyao Liang, Ruzhen Feng, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Qiujuan Li, Guang Yang, Xiaofeng Yao   +9 more
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

p53 Interacts with VDAC1, Modulating Its Expression Level and Oligomeric State to Activate Apoptosis

Biomolecules
The p53 tumor suppressor, a key transcription factor, acts as a cellular stress sensor that regulates hundreds of genes involved in responses to DNA damage, oxidative stress, and ischemia.
Elinor Gigi, Aditya Karunanithi Nivedita, Danya Ben-Hail, Manikandan Santhanam, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz   +5 more
doaj   +1 more source

VDAC1 negatively regulates melanogenesis through the Ca 2+ -calcineurin-CRTC1-MITF pathway

Life Science Alliance, 2022
This study revealed an important and novel role of mitochondrial VDAC1 in regulating melanogenesis in resting melanocytes through a Ca 2+ -regulated pathway that is independent of the alpha-MSH/UVB pathway.
Jianli Wang, Juanjuan Gong, Qiaochu Wang, Tieshan Tang, Wei Li   +4 more
doaj   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Research progress in targeting voltage-dependent anion channel-1 for cancer therapy [PDF]

Jichu yixue yu linchuang
Voltage-dependent anion channel-1 (VDAC1), a key regulator of mitochondrial function, is highly expressed in various cancers and is associated with poor prognosis.
XU Jiaai, GUO Ying, ZHANG Chao, LI He, YANG Chunhua
doaj   +1 more source