Results 71 to 80 of about 10,788 (194)

Rapid and efficient quality control analysis of isolated mitochondria by interferometric light microscopy

VIEW, EarlyView.
Mitochrial transplantation is a promising therapy to restore energy in damaged cells, but it lacks fast and reliable methods to assess mitochondrial quality before use. In this study, we used a label‐free imaging technique called interferometric light microscopy to rapidly measure the size and concentration of isolated mitochondria.
Sabah Mozafari, Christopher Ribes, Dmitry Ayollo, Florence Gazeau, Amanda K. A. Silva, Kelly Aubertin   +5 more
wiley   +1 more source

Ca2+-mediated regulation of VDAC1 expression levels is associated with cell death induction

, 2014
VDAC1, an outer mitochondrial membrane (OMM) protein, is crucial for regulating mitochondrial metabolic and energetic functions and acts as a convergence point for various cell survival and death signals. VDAC1 is also a key player in apoptosis, involved
Shoshan-Barmatz, Varda, Keinan, Nurit, Arif, Tasleem, Weisthal, Shira, Ben-Hail, Danya   +4 more
core   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Shared and specific molecular mechanisms of proteasome inhibitors in chemotherapy‐induced peripheral neurotoxicity

British Journal of Pharmacology, EarlyView.
This study compares the molecular mechanisms of chemotherapy‐related peripheral neurotoxicity of two proteasome inhibitors, bortezomib and carfilzomib, using a multidisciplinary approach to reveal that, alongside shared effects on mitochondria structure and function, the more neurotoxic drug BTZ has specific effects on microtubules and mitochondrial ...
Federico Iseppon, Alessio Malacrida, Alessia Chiorazzi, Annalisa Canta, Paola Alberti, Valentina Alda Carozzi, Eleonora Pozzi, Virginia Rodriguez‐Menendez, Laura Cherchi, Valentina Fabbro, Lisa Pagani, Elisa Tonelli, Laura Tapella, Andrea Mattarei, Sara Palermo, Daniele Cartelli, Mario Mauri, Noemi Scimia, Serena Stanga, Dmitry Lim, Carla Distasi, Marta Delconti, Clizia Chinello, Patricia Morcillo, Maria Elena Pero, Francesca Bartolini, Guido Cavaletti, Cristina Meregalli   +27 more
wiley   +1 more source

VDAC1 Topology in the Outer Mitochondrial Membrane: The Final Answer [PDF]

Biophysical Journal, 2013
The first two authors equally contributed.Voltage Dependent Anion Channel (VDAC) is a pore forming protein located in outer mitochondrial membrane (1). Its lack is lethal in human (2) and it is involved in cellular cross-talk, important in the apoptotic cascade (3).
GUARINO, FRANCESCA MARIA, Tomasello M. F., Magrì A., Impellizzeri A., Reina S., MESSINA, Angela Anna, DE PINTO, Vito Nicola   +6 more
openaire   +2 more sources

The compartment-specific interactome of VDAC1 reveals its emerging role beyond mitochondria in breast cancer

Scientific Reports
Voltage-dependent anion channel 1 (VDAC1) is a multifunctional protein that is primarily localized in the outer mitochondrial membrane, where it regulates metabolite flux and apoptosis.
Paweł Jóźwiak, Marek Mądrecki, Joanna Oracz, Marcin Jankowski, Kamila Balcerzak, Karolina Anna Kozal, Dorota Żyżelewicz, Anna Krześlak   +7 more
doaj   +1 more source

AMPK/PGC-1α and p53 modulate VDAC1 expression mediated by reduced ATP level and metabolic oxidative stress in neuronal cells

Acta Biochimica et Biophysica Sinica
Voltage-dependent anion channel 1 (VDAC1) is a pore protein located in the outer mitochondrial membrane. Its channel gating mediates mitochondrial respiration and cell metabolism, and it has been identified as a critical modulator of mitochondria ...
Wang Zhitong, Xu Tingting, Sun Yingni, Zhang Xiang, Wang Xiaoliang   +4 more
doaj   +1 more source

VDAC1 associated gene signature (VAG).

, 2014
VDAC1 associated gene signature (VAG).
Wanjun Gu (123093), Tong Zhou (3770), Hyoweon Bang (123106), Jae-Hong Ko (123110), Inja Lim (123098)   +4 more
core   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Light‐Activated Isolation of High‐Quality Mitochondria for Therapeutic Transplantation

Angewandte Chemie, Volume 138, Issue 28, 6 July 2026.
The Light‐Activated Mitochondrial Isolation (LAMI) platform enables the selective and non‐destructive isolation of high‐purity, metabolically active mitochondria. By integrating modular, ligand‐programmable magnetic probes with photo‐cleavable release, LAMI overcomes long‐standing limitations of conventional isolation methods and provides a robust ...
Hui Liu, Yuxin Jiao, Ting Zhang, Haiwei Wang, Yufei Xue, Jiayu Ding, Yang Ding, Meiling Wang, Weisen Zhang, Hua Bai, Bo Peng, Nicolas H. Voelcker, Lin Li   +12 more
wiley   +2 more sources