Results 71 to 80 of about 11,641 (203)
The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease
Pediatric Investigation, EarlyView.Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia +3 more
wiley +1 more source
VDAC1 (voltage-dependent anion channel 1) [PDF]
, 2012 Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is ...
Shoshan-Barmatz, V, Mizrachi, D
core +1 more source
Phytotherapy Research, EarlyView.Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang +9 more
wiley +1 more source
Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression
BMC Anesthesiology, 2022 Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long +5 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim +4 more
wiley +1 more source
TSPO colocalizes with VDAC1 in Leydig and Sertoli cells.
, 2013 (A) Panel shows confocal images of TSPO and VDAC1 localization in the testis. TSPO labeling is not apparent in germ cells but specific fluorescence is visible in Sertoli cells (arrowhead) and Leydig cells.
Newton S. Phuong (454429) +2 more
core +1 more source
Yeast, EarlyView.We present cryoBN‐PAGE, a method that enables blue native polyacrylamide gel electrophoresis analysis of mitochondrial respiratory complexes and supercomplexes directly from whole yeast cells using cryogenic milling. This approach eliminates the need for mitochondrial isolation, reducing time and cost while preserving native protein complexes.
Lizeth J. Camacho Lopez +3 more
wiley +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source
VDAC1 associated gene signature (VAG).
, 2014 VDAC1 associated gene signature (VAG).
Wanjun Gu (123093) +4 more
core +1 more source
The role of calcium in VDAC1 oligomerization and mitochondria-mediated apoptosis [PDF]
, 2013 The voltage-dependent anion channel (VDAC), located at the outer mitochondria membrane (OMM), mediates interactions between mitochondria and other parts of the cell by transporting anions, cations, ATP, Ca2+, and metabolites.
Pahima, Hadas +3 more
core +1 more source