Results 71 to 80 of about 17,038 (231)

Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression

BMC Anesthesiology, 2022
Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long, Xingjun Fang, Peihua Yuan, Liqin Cheng, Hongtao Li, LiangChao Qu   +5 more
doaj   +1 more source

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]

, 2020
Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila, Eghbali, Mansoureh, Medzikovic, Lejla, Umar, Soban   +3 more
core  

Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection [PDF]

, 2016
Mitochondria are the foremost producers of the cellular energy currency ATP. They are also a significant source of reactive oxygen species and an important buffer of intracellular calcium.
Bingol, Caviston, Chourasia, Cui, Daniel A. East, Duchen, East, East, Fei, Feng, Gatliff, Geisler, Guardia-Laguarta, Guo, Hanna, Jain, Jin, Kamat, Kawamata, Kim, Landes, Lee, Lee, Lefebvre, Lionaki, Liu, Lokireddy, Magrané, Martinez-Vicente, Martinou, Matic, Mattiazzi, Melser, Michalik, Michelangelo Campanella, Narendra, Narendra, Orr, Padman, Palomo, Pankiv, Panov, Pickrell, Quirós, Richter, Rugarli, Ryan, Sarraf, Schwarten, Shaw, Sheng, Shin, Stafa, Stoica, Strappazzon, Subramaniam, Tanti, Tsunemi, Valente, Van Humbeeck, Vives-Bauza, Wallace, Wang, Wang, Wu, Zhang, Zhu   +66 more
core   +2 more sources

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide

Biomolecules, 2022
The mitochondrial voltage-dependent anion channel-1 (VDAC1) protein functions in a variety of mitochondria-linked physiological and pathological processes, including metabolism and cell signaling, as well as in mitochondria-mediated apoptosis.
Uttpal Anand, Anna Shteinfer-Kuzmine, Gal Sela, Manikandan Santhanam, Benjamin Gottschalk, Rajaa Boujemaa-Paterski, Ohad Medalia, Wolfgang F. Graier, Varda Shoshan-Barmatz   +8 more
doaj   +1 more source

Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity [PDF]

, 2017
Impairments in mitochondrial function and substrate metabolism are implicated in the etiology of obesity and Type 2 diabetes. MicroRNAs (miRNAs) can degrade mRNA or repress protein translation and have been implicated in the development of such disorders.
Britton, SL, Camera, DM, Hawley, JA, Kalanon, M, Koch, LG, Lamon, S, Mikovic, J, Pinto, SK, Stephenson, EJ   +8 more
core   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

Environmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim, Wonhyoung Park, Whasun Lim, Gwonhwa Song, Sunwoo Park   +4 more
wiley   +1 more source

AMPK/PGC-1α and p53 modulate VDAC1 expression mediated by reduced ATP level and metabolic oxidative stress in neuronal cells

Acta Biochimica et Biophysica Sinica
Voltage-dependent anion channel 1 (VDAC1) is a pore protein located in the outer mitochondrial membrane. Its channel gating mediates mitochondrial respiration and cell metabolism, and it has been identified as a critical modulator of mitochondria ...
Wang Zhitong, Xu Tingting, Sun Yingni, Zhang Xiang, Wang Xiaoliang   +4 more
doaj   +1 more source

Gene expression meta-analysis identifies VDAC1 as a predictor of poor outcome in early stage non-small cell lung cancer. [PDF]

PLoS ONE, 2011
The bioenergetic status of non-small cell lung cancer correlates with tumour aggressiveness. The voltage dependent anion channel type 1 (VDAC1) is a component of the mitochondrial permeability transition pore, regulates mitochondrial ATP/ADP exchange ...
Claire Grills, Puthen V Jithesh, Jaine Blayney, Shu-Dong Zhang, Dean A Fennell   +4 more
doaj   +1 more source

Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy [PDF]

, 2017
Immune checkpoint factors, such as programmed cell death protein-1/2 (PD-1, PD-2) or cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) receptors, are targets for monoclonal antibodies (MAbs) developed for cancer immunotherapy.
Mai, Antonello, Mazzone, Roberta, Valente, Sergio, Zwergel, Clemens   +3 more
core   +1 more source