Voltage-Dependent Anion Channel 1 Expression in Oral Malignant and Premalignant Lesions [PDF]
Diagnostics, 2023 Background: The voltage-dependent anion channel 1 protein (VDAC1) plays a role in cellular metabolism and survival. It was found to be down or upregulated (overexpressed) in different malignancies but it was never studied in application to oral lesions ...
Irit Allon +5 more
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Traumatic and Diabetic Schwann Cell Demyelination Is Triggered by a Transient Mitochondrial Calcium Release through Voltage Dependent Anion Channel 1 [PDF]
Biomedicines, 2022 A large number of peripheral neuropathies, among which are traumatic and diabetic peripheral neuropathies, result from the degeneration of the myelin sheath, a process called demyelination.
Nicolas Tricaud +4 more
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Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism [PDF]
Redox Biology, 2023 Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and dysfunction.
Geer Tian +8 more
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Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia–reperfusion injury [PDF]
Neural Regeneration ResearchIschemia–reperfusion injury is a common pathophysiological mechanism in retinal degeneration. PANoptosis is a newly defined integral form of regulated cell death that combines the key features of pyroptosis, apoptosis, and necroptosis. Oligomerization of
Hao Wan +8 more
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A plausible involvement of plasmalemmal voltage‐dependent anion channel 1 in the neurotoxicity of 15‐deoxy‐Δ12,14‐prostaglandin J2 [PDF]
Brain and Behavior, 2020 Introduction 15‐deoxy‐Δ12,14‐prostaglandin J2 (15d‐PGJ2) causes neuronal apoptosis independently of its nuclear receptor, peroxysome‐proliferator activated receptor γ.
Hiromi Koma +3 more
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Voltage-Dependent Anion Channel-1, a Possible Ligand of Plasminogen Kringle 5. [PDF]
PLoS ONE, 2016 Kringle 5, the fifth fragment of plasminogen, is known to be important for inhibiting the proliferation and migration of vascular endothelial cell (VEC), while not having any effects on normal endothelial cells.
Yin-Ku Liang, Liu-Jiao Bian
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Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics [PDF]
Frontiers in Oncology, 2017 Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity,
Varda Shoshan-Barmatz +3 more
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Voltage-Dependent Anion Channel 1(VDAC1) Participates the Apoptosis of the Mitochondrial Dysfunction in Desminopathy. [PDF]
PLoS ONE, 2016 Desminopathies caused by the mutation in the gene coding for desmin are genetically protein aggregation myopathies. Mitochondrial dysfunction is one of pathological changes in the desminopathies at the earliest stage.
Huanyin Li +5 more
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Identification and validation of voltage‐dependent anion channel 1‐related genes and immune cell infiltration in diabetic nephropathy [PDF]
Journal of Diabetes InvestigationAims/Introduction This study investigated the roles of voltage‐dependent anion channel 1‐related differentially expressed genes (VRDEGs) in diabetic nephropathy (DN).
Jiaqun Lin +6 more
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Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction [PDF]
MedCommAcute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics ...
Tao Chen +14 more
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