Results 41 to 50 of about 32,223 (242)

Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux

Molecules and Cells
: Voltage dependent anion channels (VDACs 1, 2 and 3) in the outer mitochondrial membrane control the flux of anions and oxidizable substrates that sustain mitochondrial metabolism.
Seyed Majed Modaresi, Leilei Zhang, Amir Ata Saei, Morris Degen, Mohammad Khavani, Hassan Gharibi, Ákos Végvári, Zhiwei Ye, Jie Zhang, Evgeny Pavlov, Elizabeth A. Jonas, Kenneth D. Tew, Sebastian Hiller, Danyelle M. Townsend, Eduardo N. Maldonado   +14 more
doaj   +1 more source

Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer

Cellular Physiology and Biochemistry, 2015
Background/Aims: Gastric cancer (GC) remains the second leading cause of cancer-related deaths in the world. Successful early cancer detection is hampered by lack of highly sensitive and specific biomarkers.
Wen Gao, Jing Xu, Fuqiang Wang, Long Zhang, Rui Peng, Yunxia Zhu, Qiyun Tang, Jindao Wu   +7 more
doaj   +1 more source

DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1

Molecular Medicine, 2023
Background Mitochondrial metabolism has been proposed as an attractive target for breast cancer therapy. The discovery of new mechanisms underlying mitochondrial dysfunction will facilitate the development of new metabolic inhibitors to improve the ...
Ling Huang, Bo Wei, Yuran Zhao, Xue Gong, Liming Chen   +4 more
doaj   +1 more source

Flexibility of the N-Terminal mVDAC1 Segment Controls the Channel’s Gating Behavior

, 2012
Since the solution of the molecular structures of members of the voltage dependent anion channels (VDACs), the N-terminal α-helix has been the main focus of attention, since its strategic location, in combination with its putative conformational ...
Grosse, Wolfgang, Anastasia Salisowski, Koert, Ulrich, Reiss, Philipp, Ulrich Koert (125542), Georgios Psakis (125535), Katrin Christiane Back, Philipp Reiss, Mertins, Barbara, Lars-Oliver Essen (125543), Wolfgang Grosse (125537), Back, Katrin Christiane, Anastasia Salisowski (125540), Essen, Lars-Oliver, Barbara Mertins, Wolfgang Grosse, Psakis, Georgios, Barbara Mertins (125533), Philipp Reiss (125541), Lars-Oliver Essen, Georgios Psakis, Katrin Christiane Back (125538), Salisowski, Anastasia, Ulrich Koert   +23 more
core   +1 more source

A novel regulator of selective autophagy: TNIP1/ABIN-1 modulates mitophagy

Autophagy Reports, 2023
TNIP1/ABIN-1 is a novel inhibitor of inflammation and cell death. In our study, we elucidated the MAP1LC3/LC3 (microtubule associated protein 1 light chain 3)-interacting region (LIR) 1 and 2 motifs of TNIP1-dependent direct binding to LC3B-II and ...
Rosetta Merline, Liliana Schaefer
doaj   +1 more source

Over-expression of voltage dependent anion channel 1 in human endometrial cancer.

, 2021
Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial ...
Shahan Mamoor
core   +1 more source

Human erythroid differentiation requires VDAC1-mediated mitochondrial clearance

Haematologica, 2021
Erythroblast maturation in mammals is dependent on organelle clearance throughout terminal erythropoiesis. We studied the role of the outer mitochondrial membrane protein voltage-dependent anion channel-1 (VDAC1) in human terminal erythropoiesis.
Martina Moras, Claude Hattab, Pedro Gonzalez-Menendez, Claudio M. Fader, Michael Dussiot, Jerome Larghero, Caroline Le Van Kim, Sandrina Kinet, Naomi Taylor, Sophie D. Lefevre, Mariano A. Ostuni   +10 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Single-channel analysis of the anion channel-forming protein from the plant pathogenic bacterium Clavibacter michiganense ssp. nebraskense

, 1993
Schürholz T, Dloczik L, Neumann E. Single-channel analysis of the anion channel-forming protein from the plant pathogenic bacterium Clavibacter michiganense ssp. nebraskense. Biophysical Journal.
Schürholz, Theo, Neumann, Eberhard, Dloczik, Larissa   +2 more
core   +2 more sources

Combining nano-differential scanning fluorimetry and microscale thermophoresis to investigate VDAC1 interaction with small molecules

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
The mitochondrial voltage-dependent anion channel 1 (VDAC1) plays a central role in metabolism and apoptosis, which makes it a promising therapeutic target. Nevertheless, molecular mechanisms governing VDAC1 functioning remain unclear.
Hubert Gorny, Angélique Mularoni, Jean-Guy Delcros, Céline Freton, Jordane Preto, Isabelle Krimm   +5 more
doaj   +1 more source