Results 41 to 50 of about 91,818 (287)
The voltage-dependent anion channel-1 modulates apoptotic cell death [PDF]
Cell Death & Differentiation, 2005 The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in U-937 cells and VDAC inhibitors. Glutamate 72 in VDAC1, shown previously to bind dicyclohexylcarbodiimide (DCCD), which inhibits hexokinase isoform I (HK-I) binding to mitochondria, was mutated to glutamine ...
Hilal Zaid +4 more
semanticscholar +3 more sources
VDAC1 (voltage-dependent anion channel 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Shoshan-Barmatz, V, Mizrachi, D
openaire +2 more sources
Voltage-dependent anion channels 1 and 2 are expressed in porcine oocytes [PDF]
Bioscience Reports, 2009 The eukaryotic VDAC (voltage-dependent anion channel) is a pore-forming protein originally discovered in the outer membrane of mitochondria. It has been established as a key player in mitochondrial metabolism and ion signalling. In addition, in recent years, it has also been proposed that VDAC is present in extra-mitochondrial membranes, and it has ...
Cassará, María Carolina +4 more
openaire +3 more sources
ACS Applied Materials and Interfaces, 2021 Targeted therapies of melanoma are of urgent need considering the resistance of this aggressive type of cancer to chemotherapeutics. The voltage-dependent anion channel 1 (VDAC1)-hexokinase-II (HK-II) complex is an emerging target for novel anticancer ...
Fan Zhang +8 more
semanticscholar +1 more source
Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression
BMC Anesthesiology, 2022 Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long +5 more
doaj +1 more source
Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target [PDF]
Cancer Biology & Therapy, 2010 Commentary to:Down-regulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivoInbar Koren, Ziv Raviv and Varda Shoshan ...
Saroj P, Mathupala, Peter L, Pedersen
openaire +2 more sources
The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide
Biomolecules, 2022 The mitochondrial voltage-dependent anion channel-1 (VDAC1) protein functions in a variety of mitochondria-linked physiological and pathological processes, including metabolism and cell signaling, as well as in mitochondria-mediated apoptosis.
Uttpal Anand +8 more
doaj +1 more source
A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
Micromachines, 2020 Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano +6 more
doaj +1 more source
TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control [PDF]
, 2014 The 18-kDa TSPO (translocator protein) localizes on the outer mitochondrial membrane (OMM) and participates in cholesterol transport. Here, we report that TSPO inhibits mitochondrial autophagy downstream of the PINK1-PARK2 pathway, preventing essential ...
Anholt R +22 more
core +3 more sources
Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1 [PDF]
Biochemical and Biophysical Research Communications, 2010 VDAC1 is a key component of the mitochondrial permeability transition pore. To initiate apoptosis and certain other forms of cell death, mitochondria become permeable such that cytochrome c and other pre-apoptotic molecules resident inside the mitochondria enter the cytosol and activate apoptotic cascades.
Yumay, Chen +4 more
openaire +2 more sources