Results 21 to 30 of about 33,437,851 (274)
The mitochondrial voltage-dependent anion channel 1 in tumor cells [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015 VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and efflux of metabolites, ions, nucleotides, Ca2+ and more. The location of VDAC1 at the outer mitochondrial membrane also enables its interaction with proteins that mediate and ...
Shoshan-Barmatz, Varda +4 more
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Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast. [PDF]
Cell Mol Life Sci, 2020 The Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In Saccharomyces cerevisiae, inactivation of POR1, encoding VDAC1, produces defective growth in the presence of non-fermentable carbon source.
Magrì A +11 more
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Voltage-dependent anion channels 1 and 2 are expressed in porcine oocytes [PDF]
Bioscience Reports, 2009 The eukaryotic VDAC (voltage-dependent anion channel) is a pore-forming protein originally discovered in the outer membrane of mitochondria. It has been established as a key player in mitochondrial metabolism and ion signalling. In addition, in recent years, it has also been proposed that VDAC is present in extra-mitochondrial membranes, and it has ...
Cassará, María Carolina +4 more
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Dynamics and interactions of the voltage-dependent anion channel 1 studied by NMR spectroscopy [PDF]
, 2022 Der spannungsabhängige Anionenkanal (engl. “voltage-dependent anion channel”, VDAC), das häufigste Protein in der äußeren Mitochondrienmembran, dient als wichtiger Kontrollpunkt für den Ein- und Austritt von mitochondrialen Metaboliten und ist in mitochondriale Apoptose involviert.
Villinger, Saskia +5 more
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The voltage-dependent anion channel-1 modulates apoptotic cell death [PDF]
Cell Death & Differentiation, 2005 The role of the voltage-dependent anion channel (VDAC) in cell death was investigated using the expression of native and mutated murine VDAC1 in U-937 cells and VDAC inhibitors. Glutamate 72 in VDAC1, shown previously to bind dicyclohexylcarbodiimide (DCCD), which inhibits hexokinase isoform I (HK-I) binding to mitochondria, was mutated to glutamine ...
H, Zaid +4 more
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Lidocaine promotes apoptosis in breast cancer cells by affecting VDAC1 expression
BMC Anesthesiology, 2022 Objective To investigate the effect of lidocaine on the expression of voltage-dependent anion channel 1 (VDAC1) in breast invasive carcinoma (BRCA) and its impact on the apoptosis of breast cancer cells.
Dingde Long +5 more
doaj +1 more source
Voltage dependent anion channel-1 (VDAC-1) as an anti-cancer target [PDF]
Cancer Biology & Therapy, 2010 Commentary to:Down-regulation of voltage-dependent anion channel-1 expression by RNA interference prevents cancer cell growth in vivoInbar Koren, Ziv Raviv and Varda Shoshan ...
Saroj P, Mathupala, Peter L, Pedersen
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Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1. [PDF]
Protein Sci, 2017 AbstractVoltage‐dependent anion channel 1 (VDAC1), which is located in the outer mitochondrial membrane, plays important roles in various cellular processes. For example, oligomerization of VDAC1 is involved in the release of cytochrome c to the cytoplasm, leading to apoptosis. However, it is unknown how VDAC1 oligomerization occurs in the membrane. In
Hosaka T +8 more
europepmc +5 more sources
The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide
Biomolecules, 2022 The mitochondrial voltage-dependent anion channel-1 (VDAC1) protein functions in a variety of mitochondria-linked physiological and pathological processes, including metabolism and cell signaling, as well as in mitochondria-mediated apoptosis.
Uttpal Anand +8 more
doaj +1 more source
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats. [PDF]
Neurosci Bull, 2017 Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the ...
Kong X +7 more
europepmc +4 more sources