Results 21 to 30 of about 91,818 (287)

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. [PDF]

Mol Cell Biol, 2015
The oxygen-limiting (hypoxic) microenvironment of tumors induces metabolic reprogramming and cell survival, but the underlying mechanisms involving mitochondria remain poorly understood. We previously demonstrated that hypoxia-inducible factor 1 mediates the hyperfusion of mitochondria by inducing Bcl-2/adenovirus E1B 19-kDa interacting protein 3 and ...
Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM.   +17 more
europepmc   +8 more sources

Protective Effect of Treated Olive Mill Wastewater on Target Bacteria and Mitochondrial Voltage-Dependent Anion-Selective Channel 1

Antioxidants, 2023
Olive mill wastewater, a by-product of the olive oil industry, represents an important resource, rich in bioactive compounds with antioxidant activity.
Paola Foti, Stefano Conti-Nibali, Cinzia L. Randazzo, Simona Reina, Flora V. Romeo, Cinzia Caggia, Vito De Pinto   +6 more
doaj   +2 more sources

Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltage dependent anion channel 1). [PDF]

Autophagy
Exposure of inner mitochondrial membrane resident protein PHB2 (prohibitin 2) during autophagic removal of depolarized mitochondria (mitophagy) depends on the ubiquitin-proteasome system.
Roy M, Nandy S, Marchesan E, Banerjee C, Mondal R, Caicci F, Ziviani E, Chakraborty J.   +7 more
europepmc   +2 more sources

A plausible involvement of plasmalemmal voltage‐dependent anion channel 1 in the neurotoxicity of 15‐deoxy‐Δ12,14‐prostaglandin J2 [PDF]

Brain and Behavior, 2020
Introduction 15‐deoxy‐Δ12,14‐prostaglandin J2 (15d‐PGJ2) causes neuronal apoptosis independently of its nuclear receptor, peroxysome‐proliferator activated receptor γ.
Hiromi Koma, Yasuhiro Yamamoto, Noboru Okamura, Tatsurou Yagami   +3 more
doaj   +2 more sources

The mitochondrial voltage-dependent anion channel 1 in tumor cells. [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2015
VDAC1 is found at the crossroads of metabolic and survival pathways. VDAC1 controls metabolic cross-talk between mitochondria and the rest of the cell by allowing the influx and efflux of metabolites, ions, nucleotides, Ca2+ and more.
V. Shoshan-Barmatz, Danya Ben-Hail, L. Admoni, Y. Krelin, Shambhoo Sharan Tripathi   +4 more
semanticscholar   +5 more sources

Peroxynitrite nitrates adenine nucleotide translocase and voltage-dependent anion channel 1 and alters their interactions and association with hexokinase II in mitochondria. [PDF]

Mitochondrion, 2019
Cardiac ischemia and reperfusion (IR) injury induces excessive emission of deleterious reactive O2 and N2 species (ROS/RNS), including the non-radical oxidant peroxynitrite (ONOO-) that can cause mitochondria dysfunction and cell death. In this study, we
Yang M, Xu Y, Heisner JS, Sun J, Stowe DF, Kwok WM, Camara AKS.   +6 more
europepmc   +2 more sources

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction [PDF]

MedComm
Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics ...
Tao Chen, Yang Zhang, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang, Shibiao Chen, Yong Li   +14 more
doaj   +2 more sources

Protocol for high-yield bacterial expression and purification of the voltage-dependent anion channel 1 for high-throughput biophysical assays [PDF]

STAR Protocols
Summary: Voltage-dependent anion channel 1 (VDAC1) is a key protein in cellular metabolism and apoptosis. Here, we present a protocol to express and purify milligram amounts of recombinant VDAC1 in Escherichia coli.
Stefano Conti Nibali, Andrea Magrì, Angela Messina, Armin Wagner, Ramona Duman, Vito De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato   +8 more
doaj   +2 more sources

Expression profile of mitochondrial voltage-dependent anion channel-1 (VDAC1) influenced genes is associated with pulmonary hypertension. [PDF]

Korean J Physiol Pharmacol, 2017
Several human diseases have been associated with mitochondrial voltage-dependent anion channel-1 (VDAC1) due to its role in calcium ion transportation and apoptosis.
Zhou T, Tang H, Han Y, Fraidenburg D, Kim YW, Lee D, Choi J, Bang H, Ko JH.   +8 more
europepmc   +2 more sources

Clinical implication of voltage-dependent anion channel 1 in uterine cervical cancer and its action on cervical cancer cells. [PDF]

Oncotarget, 2016
Two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometry were performed to investigate the influence of human nonmetastatic clone 23 type 1 (nm23-H1), a metastasis-associated gene on proteomic alterations in cancer cells of ...
Wu CH, Lin YW, Wu TF, Ko JL, Wang PH.
europepmc   +2 more sources