Results 11 to 20 of about 33,437,851 (274)

VDAC1 (voltage-dependent anion channel 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is ...
Shoshan-Barmatz, V, Mizrachi, D
core   +4 more sources

Age-dependent prosttranslational modifications of voltage-dependent anion channel 1

Experimental Gerontology, 2010
The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems.In a quantitative study ...
Klemm-Manns, Martina, Groebe, Karlfried, Tanguay, Robert M., Unterluggauer, Herrmann, Jansen-Dürr, Pidder, Schrattenholz, André, Morrow, Geneviève, Schwall, Gerhard P., Hübenthal, Heiko   +8 more
core   +3 more sources

Tripartite Motif Containing 65 Deficiency Confers Protection Against Acute Kidney Injury via Alleviating Voltage‐Dependent Anion Channel 1–Mediated Mitochondrial Dysfunction [PDF]

MedComm
Acute kidney injury (AKI) is a prevalent and serious clinical disease with a high incidence rate and significant health burden. The limited understanding of the complex pathological mechanisms has hindered the development of efficacious therapeutics ...
Tao Chen, Yang Zhang, Liting Ding, Chenlu Xiong, Chao Mei, Sisi Wei, Ming Jiang, Yingjie Huang, Jianrong Chen, Tao Xie, Qing Zhu, Qi Zhang, Xuan Huang, Shibiao Chen, Yong Li   +14 more
doaj   +2 more sources

Protocol for high-yield bacterial expression and purification of the voltage-dependent anion channel 1 for high-throughput biophysical assays [PDF]

STAR Protocols
Summary: Voltage-dependent anion channel 1 (VDAC1) is a key protein in cellular metabolism and apoptosis. Here, we present a protocol to express and purify milligram amounts of recombinant VDAC1 in Escherichia coli.
Stefano Conti Nibali, Andrea Magrì, Angela Messina, Armin Wagner, Ramona Duman, Vito De Pinto, Cristian Turato, Cristina Arrigoni, Marco Lolicato   +8 more
doaj   +2 more sources

Small molecule inhibition of voltage dependent anion channel 1 reroutes mitochondrial metabolite flux

Molecules and Cells
: Voltage dependent anion channels (VDACs 1, 2 and 3) in the outer mitochondrial membrane control the flux of anions and oxidizable substrates that sustain mitochondrial metabolism.
Seyed Majed Modaresi, Leilei Zhang, Amir Ata Saei, Morris Degen, Mohammad Khavani, Hassan Gharibi, Ákos Végvári, Zhiwei Ye, Jie Zhang, Evgeny Pavlov, Elizabeth A. Jonas, Kenneth D. Tew, Sebastian Hiller, Danyelle M. Townsend, Eduardo N. Maldonado   +14 more
doaj   +2 more sources

Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. [PDF]

PLoS ONE, 2014
Mitochondrial voltage-dependent anion channels (VDACs) play a key role in mitochondria-mediated apoptosis. Both in vivo and in vitro evidences indicate that VDACs are actively involved in tumor progression.
Jae-Hong Ko, Wanjun Gu, Inja Lim, Tong Zhou, Hyoweon Bang   +4 more
doaj   +2 more sources

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

Neurobiology of Disease, 2014
Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear.
Yaping Chu, Jennifer G. Goldman, Leo Kelly, Yinzhen He, Tracy Waliczek, Jeffrey H. Kordower   +5 more
doaj   +3 more sources

Mitochondrial Proteomics Approach Reveals Voltage-Dependent Anion Channel 1 (VDAC1) as a Potential Biomarker of Gastric Cancer

Cellular Physiology and Biochemistry, 2015
Background/Aims: Gastric cancer (GC) remains the second leading cause of cancer-related deaths in the world. Successful early cancer detection is hampered by lack of highly sensitive and specific biomarkers.
Wen Gao, Jing Xu, Fuqiang Wang, Long Zhang, Rui Peng, Yunxia Zhu, Qiyun Tang, Jindao Wu   +7 more
doaj   +3 more sources

The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell.

PLoS ONE, 2013
Voltage-Dependent Anion selective Channel maintains the permeability of the outer mitochondrial membrane and is relevant in bioenergetic metabolism and apoptosis. The structure of the protein was shown to be a β-barrel formed by 19 strands.
Marianna F Tomasello, Francesca Guarino, Simona Reina, Angela Messina, Vito De Pinto   +4 more
doaj   +4 more sources

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca²⁺ Transport, Apoptosis, and Their Regulation. [PDF]

Front Oncol, 2017
In the outer mitochondrial membrane, the voltage-dependent anion channel 1 (VDAC1) functions in cellular Ca2+ homeostasis by mediating the transport of Ca2+ in and out of mitochondria. VDAC1 is highly Ca2+-permeable and modulates Ca2+ access to the mitochondrial intermembrane space.
Shoshan-Barmatz V, De S, Meir A.
europepmc   +4 more sources