Results 11 to 20 of about 91,818 (287)

The Mitochondrial Voltage-Dependent Anion Channel 1, Ca²⁺ Transport, Apoptosis, and Their Regulation. [PDF]

Front Oncol, 2017
In the outer mitochondrial membrane, the voltage-dependent anion channel 1 (VDAC1) functions in cellular Ca2+ homeostasis by mediating the transport of Ca2+ in and out of mitochondria.
Shoshan-Barmatz V, De S, Meir A.
europepmc   +5 more sources

Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities. [PDF]

Oncotarget, 2018
The voltage-dependent anion channel 1 (VDAC1), an outer mitochondria membrane (OMM) protein, serves as a mitochondrial gatekeeper, mediating the transport of nucleotides, Ca2+ and other metabolites across the OMM.
Pahima H, Reina S, Tadmor N, Dadon-Klein D, Shteinfer-Kuzmine A, Mazure NM, De Pinto V, Shoshan-Barmatz V.   +7 more
europepmc   +5 more sources

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

Neurobiology of Disease, 2014
Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear.
Yaping Chu, Jennifer G. Goldman, Leo Kelly, Yinzhen He, Tracy Waliczek, Jeffrey H. Kordower   +5 more
doaj   +4 more sources

Expression profiling of mitochondrial voltage-dependent anion channel-1 associated genes predicts recurrence-free survival in human carcinomas. [PDF]

PLoS ONE, 2014
Mitochondrial voltage-dependent anion channels (VDACs) play a key role in mitochondria-mediated apoptosis. Both in vivo and in vitro evidences indicate that VDACs are actively involved in tumor progression.
Jae-Hong Ko, Wanjun Gu, Inja Lim, Tong Zhou, Hyoweon Bang   +4 more
doaj   +3 more sources

Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast. [PDF]

Cell Mol Life Sci, 2020
The Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In Saccharomyces cerevisiae, inactivation of POR1, encoding VDAC1, produces defective growth in the presence of non-fermentable carbon source.
Magrì A, Di Rosa MC, Orlandi I, Guarino F, Reina S, Guarnaccia M, Morello G, Spampinato A, Cavallaro S, Messina A, Vai M, De Pinto V.   +11 more
europepmc   +6 more sources

The Association of Mitochondrial Translocator Protein and Voltage-Dependent Anion Channel-1 in Granulosa Cells with Estradiol Levels and Presence of Immature Follicles in Polycystic Ovary Syndrome. [PDF]

J Reprod Infertil, 2022
Background: Granulosa cells (GCs) play key roles in oocyte maturation by providing required estradiol (E2). Since the presence of immature oocytes has been reported in cases with polycystic ovary syndrome (PCOS), in this study, the levels of ...
Mazloomi S, Sanoeei Farimani M, Tayebinia H, Karimi J, Amiri I, Abbasi E, Khodadadi I.   +6 more
europepmc   +2 more sources

Crystal structural characterization reveals novel oligomeric interactions of human voltage-dependent anion channel 1. [PDF]

Protein Sci, 2017
AbstractVoltage‐dependent anion channel 1 (VDAC1), which is located in the outer mitochondrial membrane, plays important roles in various cellular processes. For example, oligomerization of VDAC1 is involved in the release of cytochrome c to the cytoplasm, leading to apoptosis. However, it is unknown how VDAC1 oligomerization occurs in the membrane. In
Hosaka T, Okazaki M, Kimura-Someya T, Ishizuka-Katsura Y, Ito K, Yokoyama S, Dodo K, Sodeoka M, Shirouzu M.   +8 more
europepmc   +5 more sources

Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats. [PDF]

Neurosci Bull, 2017
Voltage-dependent anion channel 1 (VDAC1) is thought to contribute to the progression of tumor development. However, whether VDAC1 contributes to bone cancer pain remains unknown. In this study, we found that the expression of VDAC1 was upregulated in the L2-5 segments of the spinal dorsal horn at 2 and 3 weeks after injection of tumor cells into the ...
Kong X, Wei J, Wang D, Zhu X, Zhou Y, Wang S, Xu GY, Jiang GQ.   +7 more
europepmc   +5 more sources

Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1. [PDF]

Int J Mol Med, 2020
20(S)-Ginsenoside Rh2 [20(S)-GRh2], one of the main active components of Panaxginseng, induces apoptosis in a wide range of cancer cell types. The present study found that 20(S)-GRh2 reduces mitochondrial membrane potential, decreases adenosine ...
Liu Y, Wang J, Qiao J, Liu S, Wang S, Zhao D, Bai X, Liu M.   +7 more
europepmc   +2 more sources

The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy [PDF]

Journal of Biological Chemistry, 2015
Danya Ben-Hail, Dario Mizrachi, Varda Shoshan-Barmatz   +2 more
exaly   +3 more sources