Results 31 to 40 of about 32,223 (242)

VDAC1 (voltage-dependent anion channel 1) [PDF]

, 2012
Review on VDAC1 (voltage-dependent anion channel 1), with data on DNA, on the protein encoded, and where the gene is ...
Shoshan-Barmatz, V, Mizrachi, D
core   +1 more source

Two-electrode Voltage-clamp Recordings in Xenopus laevis Oocytes：Reconstitution of Abscisic Acid Activation of SLAC1 Anion Channel via PYL9 ABA Receptor

Bio-Protocol, 2017
Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
doaj   +1 more source

Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. [PDF]

Mol Cell Biol, 2015
The oxygen-limiting (hypoxic) microenvironment of tumors induces metabolic reprogramming and cell survival, but the underlying mechanisms involving mitochondria remain poorly understood. We previously demonstrated that hypoxia-inducible factor 1 mediates
Brahimi-Horn MC, Lacas-Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, Dieu M, Michiels C, Voeltzel T, Maguer-Satta V, Pelletier J, Ilie M, Hofman P, Manoury B, Schmidt A, Hiller S, Pouysségur J, Mazure NM.   +17 more
europepmc   +3 more sources

Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration [PDF]

, 2012
Stomata account for much of the 70% of global water usage associated with agriculture and have a profound impact on the water and carbon cycles of the world.
Yizhou Wang, Adrian Hills, Lew, V.L., Mary Williams, Hills, A., Virgilio L. Lew, Eisenach, C., Papanatsiou, M., Michael R. Blatt, Williams, M., Karnik, R., Maria Papanatsiou, Cornelia Eisenach, Rucha Karnik, Wang, Y., Blatt, M.R.   +15 more
core   +1 more source

Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

Neurobiology of Disease, 2014
Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear.
Yaping Chu, Jennifer G. Goldman, Leo Kelly, Yinzhen He, Tracy Waliczek, Jeffrey H. Kordower   +5 more
doaj   +1 more source

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
Background The cardiac microvascular system ischemia/reperfusion injury following percutaneous coronary intervention is a clinical thorny problem. This study explores the mechanisms by which ischemia/reperfusion injury induces cardiac microcirculation ...
Hao Zhou, Shunying Hu, Qinhua Jin, Chen Shi, Ying Zhang, Pingjun Zhu, Qiang Ma, Feng Tian, Yundai Chen   +8 more
doaj   +1 more source

Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1. [PDF]

Int J Mol Sci
The small GTPase RAS acts as a plasma membrane-anchored intracellular neurotrophin counteracting neuronal degeneration in the brain, but the underlying molecular mechanisms are largely unknown.
Neumann S, Kuteykin-Teplyakov K, Heumann R.   +2 more
europepmc   +2 more sources

Role of voltage-dependent anion channel 1 in neurodegeneration: Mechanisms, implications, and therapeutic potential

Neural Regeneration Research
Voltage-dependent anion channel 1 is an integral outer membrane protein of the mitochondria that governs apoptosis, enables metabolite exchange, and influences mitochondrial activity.
Astha Parikh, Anas Cholavaram, Ajith Kumar Chitti Babu, Kanagavel Deepankumar, Murali Vijayan   +4 more
doaj   +1 more source

VDAC1 oligomerization may enhance DDP‐induced hepatocyte apoptosis by exacerbating oxidative stress and mitochondrial DNA damage

FEBS Open Bio, 2022
Cisplatin (DDP)‐based chemotherapy is a preferred treatment for a broad spectrum of cancers, but the precise mechanisms of its hepatotoxicity are not yet clear.
Xueqin Zhu, Lei Luo, Yanyan Xiong, Nan Jiang, Yurun Wang, Yuan Lv, Ying Xie   +6 more
doaj   +1 more source

Solute channels of the outer membrane: from bacteria to chloroplasts [PDF]

, 2007
Chloroplasts, unique organelles of plants, originated from endosymbiosis of an ancestor of today's cyanobacteria with a mitochondria-containing host cell. It is assumed that the outer envelope membrane, which delimits the chloroplast from the surrounding
Philippar, Katrin, Soll, Jürgen, Duy, Daniela   +2 more
core   +1 more source