Hepatitis C virus replication requires integrity of mitochondria-associated ER membranes
JHEP Reports, 2023 Background & Aims: Chronic HCV infection causes cellular stress, fibrosis and predisposes to hepatocarcinogenesis. Mitochondria play key roles in orchestrating stress responses by regulating bioenergetics, inflammation and apoptosis.
Sarah Duponchel +13 more
doaj +1 more source
Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα
Molecular & Cellular Oncology, 2021 IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB.
Evangelos Pazarentzos
doaj +1 more source
Advanced Science, 2023 Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure.
Cong Liu +9 more
doaj +1 more source
Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure [PDF]
, 2015 Hydrogen sulphide (H2S) is the third biological gasotransmitter and, in animals, affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse physiological responses. H2S closes
Blatt, Mike R. +3 more
core +2 more sources
Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
Molecular Therapy: Nucleic Acids, 2014 Alterations in cellular metabolism and bioenergetics are vital for cancer cell growth and motility. Here, the role of the mitochondrial protein voltage-dependent anion channel (VDAC1), a master gatekeeper regulating the flux of metabolites and ions ...
Tasleem Arif +4 more
doaj +1 more source
Protocol: optimised electrophyiological analysis of intact guard cells from arabidopsis [PDF]
, 2012 Genetic resources available for Arabidopsis thaliana make this species particularly attractive as a model for molecular genetic studies of guard cell homeostasis, transport and signalling, but this facility is not matched by accessible tools for ...
Blatt, M.R. +4 more
core +3 more sources
Age-dependent posttranslational modifications of voltage-dependent anion channel 1
Experimental Gerontology, 2010 The accumulation of oxidative damage in mitochondrial proteins, membranes and DNA during ageing is supposed to lead to mitochondrial inactivation, downstream molecular impairments and subsequent decline of biological systems. In a quantitative study investigating the age-related changes of mitochondrial proteins on the level of oxidative ...
Karlfried, Groebe +8 more
openaire +2 more sources
Neuronal and astroglial correlates underlying spatiotemporal Intrinsic Optical Signal in the rat hippocampal slice [PDF]
, 2013 Widely used for mapping afferent activated brain areas in vivo, the label-free intrinsic optical signal (IOS) is mainly ascribed to blood volume changes subsequent to glial glutamate uptake.
Héja, László +3 more
core +6 more sources
Bio-Protocol, 2017 Two-Electrode Voltage-Clamp (TEVC) recording in Xenopus laevis oocytes provides a powerful method to investigate the functions and regulation of ion channel proteins.
cun wang, Jingbo Zhang, Julian Schroeder
doaj +1 more source
Self-organised criticality and 1/ f noise in single-channel current of voltage-dependent anion channel [PDF]
Europhysics Letters (EPL), 2006 Noise profile of Voltage Dependent Anion Channel (VDAC) is investigated in open channel state. Single-channel currents through VDAC from mitochondria of rat brain reconstituted into a planar lipid bilayer are recorded under different voltage clamped conditions across the membrane.
Banerjee, Jyotirmoy +3 more
openaire +2 more sources