Results 11 to 20 of about 10,788 (194)

VDAC1: From structure to cancer therapy [PDF]

Frontiers in Oncology, 2012
Here, we review current evidence pointing to the function of VDAC1 in cell life and death, and highlight these functions in relation to cancer. Found at the outer mitochondrial membrane, VDAC1 assumes a crucial position in the cell, controlling the ...
Varda eShoshan-Barmatz, Dario eMizrachi
doaj   +4 more sources

VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress [PDF]

Cell Stress, 2017
This review presents current knowledge related to VDAC1 as a multi-functional mitochondrial protein acting on both sides of the coin, regulating cell life and death, and highlighting these functions in relation to disease. It is now recognized that VDAC1
Varda Shoshan-Barmatz, Eduardo N. Maldonado, Yakov Krelin   +2 more
doaj   +4 more sources

A VDAC1-Derived N-Terminal Peptide Inhibits Mutant SOD1-VDAC1 Interactions and Toxicity in the SOD1 Model of ALS [PDF]

Frontiers in Cellular Neuroscience, 2019
Mutations in superoxide dismutase (SOD1) are the second most common cause of familial amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease caused by the death of motor neurons in the brain and spinal cord.
Anna Shteinfer-Kuzmine, Shirel Argueti, Rajeev Gupta, Neta Shvil, Salah Abu-Hamad, Yael Gropper, Jan Hoeber, Andrea Magrì, Angela Messina, Elena N. Kozlova, Varda Shoshan-Barmatz, Adrian Israelson   +11 more
doaj   +6 more sources

The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide [PDF]

Biomolecules, 2022
The mitochondrial voltage-dependent anion channel-1 (VDAC1) protein functions in a variety of mitochondria-linked physiological and pathological processes, including metabolism and cell signaling, as well as in mitochondria-mediated apoptosis.
Uttpal Anand, Anna Shteinfer-Kuzmine, Gal Sela, Manikandan Santhanam, Benjamin Gottschalk, Rajaa Boujemaa-Paterski, Ohad Medalia, Wolfgang F. Graier, Varda Shoshan-Barmatz   +8 more
doaj   +6 more sources

Decoding Cancer through Silencing the Mitochondrial Gatekeeper VDAC1

Biomolecules
Mitochondria serve as central hubs for regulating numerous cellular processes that include metabolism, apoptosis, cell cycle progression, proliferation, differentiation, epigenetics, immune signaling, and aging.
Tasleem Arif, Anna Shteinfer-Kuzmine, Varda Shoshan-Barmatz   +2 more
doaj   +5 more sources

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target [PDF]

Frontiers in Physiology, 2017
Mitochondria are the key source of ATP that fuels cellular functions, and they are also central in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been implicated in a wide range of diseases, including neurodegenerative ...
Amadou K. S. Camara, Amadou K. S. Camara, YiFan Zhou, Po-Chao Wen, Emad Tajkhorshid, Wai-Meng Kwok, Wai-Meng Kwok, Wai-Meng Kwok   +7 more
doaj   +4 more sources

Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1

Pharmaceuticals
Background: Besides diabetes mellitus, metformin has been identified as a potential therapeutic agent for treating various other conditions that include various cancers, cardiovascular diseases, neurodegenerative diseases, and aging. In cancer, metformin
Anna Shteinfer-Kuzmine, Meital M. Moyal, Aditya Karunanithi Nivedita, Sweta Trishna, Almog Nadir, Shubhandra Tripathi, Varda Shoshan-Barmatz   +6 more
doaj   +4 more sources

News about VDAC1 in Hypoxia [PDF]

Frontiers in Oncology, 2016
The voltage-dependent anion channel (VDAC) is the main interface between the cytosol and mitochondria of cells. It plays a crucial role in both mitochondrial metabolism and cell death. The main basic function of this channel is to mediate and gate the flux of small ions, metabolites, and adenosine triphosphate.
Nathalie M. Mazure, N. M. Mazure
openaire   +4 more sources

HSP90 C-terminal domain inhibition promotes VDAC1 oligomerization via decreasing K274 mono-ubiquitination in Hepatocellular Carcinoma [PDF]

Neoplasia: An International Journal for Oncology Research, 2023
Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress.
Jinxin Zhang, Lixia Liu, Yan Li, Yaling Huang, Senbo Xiao, Zihao Deng, Zhenming Zheng, Jieyou Li, Manfeng Liang, Guantai Xie, Xiao Chen, Yaotang Deng, Wenchong Tan, Hairou Su, Guibing Wu, Chunqing Cai, Xuemei Chen, Fei Zou   +17 more
doaj   +2 more sources

PGC1α and VDAC1 expression in endometrial cancer

Molecular and Clinical Oncology, 2020
Endometrial cancer (EC) is one of the ten most common gynecological cancers. As in most cancers, EC tumour progression involves alterations in cellular metabolism and can be associated with, for instance, altered levels of glycolytic enzymes. Mitochondrial functions and proteins are known to serve key roles in tumour metabolism and progression.
Ofra Castro, Wersäll, Lina, Löfstedt, Igor, Govorov, Miriam, Mints, Marike, Gabrielson, Maria, Shoshan   +5 more
openaire   +4 more sources