Results 11 to 20 of about 17,038 (231)
Metformin-Induced Apoptosis Is Mediated Through Mitochondrial VDAC1
PharmaceuticalsBackground: Besides diabetes mellitus, metformin has been identified as a potential therapeutic agent for treating various other conditions that include various cancers, cardiovascular diseases, neurodegenerative diseases, and aging. In cancer, metformin
Anna Shteinfer-Kuzmine +6 more
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VDAC1: The mitochondrial gatekeeper in the battle against hearing loss (Review). [PDF]
Biomed RepThe development of hearing loss is strongly associated with mitochondrial damage, particularly downstream of mitochondrial autophagy, which is a process that is coincidentally key for selectively removing damaged mitochondria.
Ding ZJ, Wang Y.
europepmc +2 more sources
VDAC1-interacting proteins: binding site mapping and their derived peptides induce apoptosis and multifaceted cellular effects. [PDF]
ApoptosisThe mitochondrial voltage-dependent anion channel-1 (VDAC1) protein plays a central role in regulating mitochondrial metabolism, energy production, and apoptosis.
Santhanam M +4 more
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VDAC1 Intervention Alleviates Bisphenol AF-Induced Succinate Metabolism Dysregulation and Inflammatory Responses [PDF]
PharmaceuticalsBackground/Objectives: Bisphenol AF (BPAF) is a prevalent environmental contaminant with demonstrated metabolic and immunological toxicity. This study aimed to investigate whether VDAC1 (Voltage-Dependent Anion Channel 1) mediates BPAF-induced succinate ...
Xinyu Hong +7 more
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Experimental and Molecular MedicineMetformin (MetF) is used worldwide as a first-line therapy for type 2 diabetes. Recently, interest in the pleiotropic effects of MetF, such as its anticancer and antiaging properties, has increased.
Minjeong Ko +8 more
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Neoplasia: An International Journal for Oncology Research, 2023 Voltage-dependent anion-selective channel protein 1 (VDAC1) is the most abundant protein in the mitochondrial outer membrane and plays a crucial role in the control of hepatocellular carcinoma (HCC) progress.
Jinxin Zhang +17 more
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VDAC1: A Key Player in the Mitochondrial Landscape of Neurodegeneration
BiomoleculesVoltage-Dependent Anion Channel 1 (VDAC1) is a mitochondrial outer membrane protein that plays a crucial role in regulating cellular energy metabolism and apoptosis by mediating the exchange of ions and metabolites between mitochondria and the cytosol ...
Shirel Argueti-Ostrovsky +3 more
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VDAC1-based peptide as potential treatment for pathologies of the liver and pancreas
Медицинский совет, 2022 Diseases associated with damage to such vital organs of the digestive system as the liver and pancreas are an urgent problem of world health. Non-alcoholic fatty liver disease (NAFLD) is a worldwide epidemic; the problem of type 2 diabetes (T2D) mellitus
V. N. Nikolenko +3 more
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Вавиловский журнал генетики и селекции, 2023 The phenomenon of DNA import into mitochondria has been shown for all major groups of eukaryotes. In plants and animals, DNA import seems to occur in different ways. It has been known that nucleic acids enter plant organelles through alternative channels,
T. A. Tarasenko +4 more
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VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway
Cell Death and Disease, 2022 The voltage-dependent anion channel 1 (VDAC1) was first described as a mitochondrial porin that mediates the flux of metabolites and ions, thereby integrating both cell survival and death signals.
Erica de Sousa +9 more
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