Results 21 to 30 of about 21,928 (305)
Nucleotide Interactions of the Human Voltage-dependent Anion Channel [PDF]
Journal of Biological Chemistry, 2014 The voltage-dependent anion channel (VDAC) mediates and gates the flux of metabolites and ions across the outer mitochondrial membrane and is a key player in cellular metabolism and apoptosis. Here we characterized the binding of nucleotides to human VDAC1 (hVDAC1) on a single-residue level using NMR spectroscopy and site-directed mutagenesis.
Saskia Villinger +6 more
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VDAC: Voltage Dependant Anion Channel
The FASEB Journal, 2011 VDAC (Voltage Dependent Anion Channel) is a channel protein located on the outer mitochondrial membrane. It regulates mitochondria functions and cell respiration through the exchange of molecules between the cytoplasm and the organelle, such as ADP, ATP, anions, cations, and other small, hydrophilic molecules.
Patrick Jordan +18 more
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Subcellular Localization of Human Voltage-dependent Anion Channel Isoforms [PDF]
Journal of Biological Chemistry, 1995 The voltage-dependent anion channel of the outer mitochondrial membrane, VDAC (also known as mitochondrial porin), is a small abundant protein which forms a voltage-gated pore when incorporated into planar lipid bilayers. This protein forms the primary pathway for movement of major metabolites through the outer membrane.
W H, Yu, W, Wolfgang, M, Forte
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Neuroactive Steroids: Receptor Interactions and Responses
Frontiers in Neurology, 2017 Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs).
Kald Beshir Tuem, Tesfay Mehari Atey
doaj +1 more source
A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings
Micromachines, 2020 Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano +6 more
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β-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel [PDF]
Structure, 2012 The voltage-dependent anion channel (VDAC) is the major protein in the outer mitochondrial membrane, where it mediates transport of ATP and ADP. Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in apoptotic pathways.
Zachariae, Ulrich +12 more
openaire +5 more sources
LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Nature Communications, 2018 Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening.
Till Stuhlmann +2 more
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Physiology and pathophysiology of ClC-K/barttin channels
Frontiers in Physiology, 2010 ClC-K channels form a subgroup of anion channels within the ClC family of anion transport proteins. They are expressed predominantly in the kidney and in the inner ear, and are necessary for NaCl resorption in the loop of Henle and for K+ secretion by ...
Christoph eFahlke, Martin eFischer
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Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions
Frontiers in Physiology, 2021 Mitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria.
Maria Carmela Di Rosa +7 more
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Arabidopsis voltage-dependent anion channel 1 (AtVDAC1) is required for female development and maintenance of mitochondrial functions related to energy-transaction. [PDF]
PLoS ONE, 2014 The voltage-dependent anion channels (VDACs), prominently localized in the outer mitochondrial membrane, play important roles in the metabolite exchange, energy metabolism and mitochondria-mediated apoptosis process in mammalian cells.
Xiaodi Pan +3 more
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