Voltage-Dependent Anion Selective Channel Isoforms in Yeast: Expression, Structure, and Functions
Frontiers in Physiology, 2021 Mitochondrial porins, also known as voltage-dependent anion selective channels (VDACs), are pore-forming molecules of the outer mitochondrial membranes, involved in the regulation of metabolic flux between cytosol and mitochondria.
Maria Carmela Di Rosa +7 more
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β-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel [PDF]
Structure, 2012 The voltage-dependent anion channel (VDAC) is the major protein in the outer mitochondrial membrane, where it mediates transport of ATP and ADP. Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in apoptotic pathways.
Zachariae, Ulrich +12 more
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LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
Nature Communications, 2018 Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening.
Till Stuhlmann +2 more
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Physiology and pathophysiology of ClC-K/barttin channels
Frontiers in Physiology, 2010 ClC-K channels form a subgroup of anion channels within the ClC family of anion transport proteins. They are expressed predominantly in the kidney and in the inner ear, and are necessary for NaCl resorption in the loop of Henle and for K+ secretion by ...
Christoph eFahlke, Martin eFischer
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Arabidopsis voltage-dependent anion channel 1 (AtVDAC1) is required for female development and maintenance of mitochondrial functions related to energy-transaction. [PDF]
PLoS ONE, 2014 The voltage-dependent anion channels (VDACs), prominently localized in the outer mitochondrial membrane, play important roles in the metabolite exchange, energy metabolism and mitochondria-mediated apoptosis process in mammalian cells.
Xiaodi Pan +3 more
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Cell-free electrophysiology of human VDACs incorporated into nanodiscs: An improved method
Biophysical Reports, 2021 Voltage-dependent anion-selective channel (VDAC) is one of the main proteins of the outer mitochondrial membrane of all eukaryotes, where it forms aqueous, voltage-sensitive, and ion-selective channels.
Stefano Conti Nibali +5 more
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Amphiphilic blockers punch through a mutant CLC-0 pore. [PDF]
, 2009 Intracellularly applied amphiphilic molecules, such as p-chlorophenoxy acetate (CPA) and octanoate, block various pore-open mutants of CLC-0. The voltage-dependent block of a particular pore-open mutant, E166G, was found to be multiphasic. In symmetrical
Chen, Tsung-Yu, Zhang, Xiao-Dong
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MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Microcrystal electron diffraction (MicroED) is an electron cryo-microscopy (cryoEM) method for determining structures using submicron crystals. Until now, determining structures of membrane proteins by MicroED required that the protein crystals be in a solution amenable to standard cryoEM blotting and vitrification ...
Michael W. Martynowycz +4 more
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SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia
Nature Communications, 2018 Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here Kang et al.
Chen Kang +10 more
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Frontiers in Physiology, 2021 The voltage-dependent anion-selective channel (VDAC) is a porin in the mitochondrial outer membrane (MOM). Unlike bacterial porins, several mitochondrial β-barrels comprise an odd number of β-strands, as is the case for the 19-β-stranded VDAC. Previously,
Fraser G. Ferens +5 more
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