A novel binding site between the voltage-dependent calcium channel CaV1.2 subunit and CaVβ2 subunit discovered using a new analysis method for protein–protein interactions [PDF]
Scientific Reports, 2023 We developed a new method to analyze protein–protein interactions using a dual-inducible prokaryotic expression system. To evaluate protein–protein binding, a chimeric fusion toxin gene was constructed using a DNase-treated short DNA fragment (epitope ...
Agnieszka M. Murakami +5 more
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Bio-inspired voltage-dependent calcium channel blockers. [PDF]
Nat Commun, 2013 Ca(2+) influx via voltage-dependent CaV1/CaV2 channels couples electrical signals to biological responses in excitable cells. CaV1/CaV2 channel blockers have broad biotechnological and therapeutic applications. Here we report a general method for developing novel genetically encoded calcium channel blockers inspired by Rem, a small G-protein that ...
Yang T +4 more
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Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration [PDF]
Drug Design, Development and Therapy, 2023 Lian Zhong,1,* Xiaoyu Cao,2,* Li Li,1 Yuanyuan He,1 Yanxia Liu,1 Weiwei Chen,1 Fuzhen Yang,1 Ni Xiao,1 Jun Zhang,1 Huifen He3 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of ...
Zhong L +9 more
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Shear-induced ciliary autotomy mediated by a TRP channel and a voltage-dependent calcium channel [PDF]
iScienceSummary: Cilium, an organelle for sensory transduction and cell motility, dynamically grows and disappears depending on stimulus perception and cell-cycle progression.
Shiyi Hui +6 more
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Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii. [PDF]
PLoS Pathog, 2017 Kanatani S +7 more
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Fast Inactivation of Voltage-dependent Calcium Channels [PDF]
Journal of Biological Chemistry, 2000 Stephanie C. Stotz +4 more
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Transcriptional analysis reveals a markedly reduced expression of the voltage-dependent calcium channel α2δ1 subunit in canine prostate cancer compared to benign prostatic hyperplasia. [PDF]
BMC Vet ResZacharski M +10 more
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Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. [PDF]
PLoS ONE, 2014 Anoctamin1 (Ano1, or TMEM16A) is a Ca2+-activated chloride channel that is gated by both voltage and Ca2+. We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium ...
Qinghuan Xiao, Yuanyuan Cui
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Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts. [PDF]
PLoS ONE, 2015 Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including ...
Xuemei Zhang +6 more
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Voltage-dependent calcium channels.
General physiology and biophysics, 2005 Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA). Auxiliary subunits of the HVA calcium channels contribute significantly to biophysical properties of the channels.
LUBICA LACINOVÁ, FRANZ HOFMANN
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