Bio-inspired voltage-dependent calcium channel blockers. [PDF]
Nat Commun, 2013 Ca2+ influx via voltage-dependent CaV1/CaV2 channels couples electrical signals to biological responses in excitable cells. CaV1/CaV2 channel blockers have broad biotechnological and therapeutic applications.
Yang T +4 more
europepmc +8 more sources
Renzhu Ointment Regulates L-Type Voltage-Dependent Calcium Channel in Mice Model of Senna-Induced Diarrhea by Transdermal Administration [PDF]
Drug Design, Development and Therapy, 2023 Lian Zhong,1,* Xiaoyu Cao,2,* Li Li,1 Yuanyuan He,1 Yanxia Liu,1 Weiwei Chen,1 Fuzhen Yang,1 Ni Xiao,1 Jun Zhang,1 Huifen He3 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of ...
Zhong L +9 more
doaj +2 more sources
The Requirement of L-Type Voltage-Dependent Calcium Channel (L-VDCC) in the Rapid-Acting Antidepressant-Like Effects of Scopolamine in Mice. [PDF]
Int J Neuropsychopharmacol, 2018 Background Previous studies have shown that a low dose of scopolamine produces rapid-acting antidepressant-like actions in rodents. Understanding the mechanisms underlying this effect and the dose-dependent variations of drug responses remains an ...
Yu H +8 more
europepmc +2 more sources
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channels [PDF]
eLife, 2016 The auxiliary α2δ subunits of voltage-gated calcium channels are extracellular membrane-associated proteins, which are post-translationally cleaved into disulfide-linked polypeptides α2 and δ.
Ivan Kadurin +11 more
doaj +5 more sources
A novel binding site between the voltage-dependent calcium channel CaV1.2 subunit and CaVβ2 subunit discovered using a new analysis method for protein–protein interactions [PDF]
Scientific Reports, 2023 We developed a new method to analyze protein–protein interactions using a dual-inducible prokaryotic expression system. To evaluate protein–protein binding, a chimeric fusion toxin gene was constructed using a DNase-treated short DNA fragment (epitope ...
Agnieszka M. Murakami +5 more
doaj +2 more sources
The Voltage-dependent Calcium Channel β Subunit Contains Two Stable Interacting Domains* [PDF]
Journal of Biological Chemistry, 2003 Voltage-dependent calcium channels selectively enable Ca2+ ion movement through cellular membranes. These multiprotein complexes are involved in a wide spectrum of biological processes such as signal transduction and cellular homeostasis.
Y. Opatowsky +4 more
semanticscholar +2 more sources
L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes [PDF]
Journal of Neuroscience, 2009 The perirhinal cortex of the temporal lobe is essential for the familiarity discrimination component of recognition memory. In view of the importance of changes in calcium ion concentration for synaptic plasticity, the present study examined the effects ...
Ana Seoane +4 more
semanticscholar +2 more sources
Functional Properties of a New Voltage-dependent Calcium Channel α2δ Auxiliary Subunit Gene (CACNA2D2) * [PDF]
Journal of Biological Chemistry, 2000 We have positionally cloned and characterized a new calcium channel auxiliary subunit, α2δ-2 (CACNA2D2), which shares 56% amino acid identity with the known α2δ-1 subunit.
B. Gao +11 more
semanticscholar +2 more sources
Biological and Pharmaceutical Bulletin, 2009 We compared the inhibitory action of gabapentin, which is used to treat neuropathic pain, on mechanical allodynia induced by chemotherapeutic agents, paclitaxel, oxaliplatin, and vincristine, in mice.
Punam Gauchan +6 more
semanticscholar +3 more sources
Abundant expression and cytoplasmic aggregations of [alpha]1A voltage-dependent calcium channel protein associated with neurodegeneration in spinocerebellar ataxia type 6. [PDF]
Human Molecular Genetics, 1999 K. Ishikawa +15 more
semanticscholar +2 more sources