Results 261 to 270 of about 95,928 (309)

INVERTEBRATE VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBTYPES

Biological Reviews, 1996
82494
Skeer, JM, Norman, RI, Sattelle, DB
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Voltage‐Dependent Calcium Channel Mutations in Neurological Disease

Annals of the New York Academy of Sciences, 1999
ABSTRACT: Calcium ion channel mutations disrupt channel function and create recognizable disease phenotypes in the nervous system. The broad array of underlying cellular alterations is commensurate with the expanding genetic diversity of the voltage‐gated calcium ion channel complex and its critical role in regulating cell function.
D L, Burgess, J L, Noebels
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Acetaldehyde Inhibits Current through Voltage-Dependent Calcium Channels

Toxicology and Applied Pharmacology, 1997
Ethanol consumption is often accompanied by an increase in both cardiac and vascular dysfunction. Underlying mechanisms may include direct actions of acetaldehyde (ACA), the principal by-product of ethanol metabolism, which has previously been shown to decrease both KCl- and nonrepinephrine-elicited contractions of isolated aortic rings.
J A, Morales, J L, Ram, J, Song, R A, Brown   +3 more
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Voltage-dependent calcium channels in mammalian spermatozoa revisited

Frontiers in Bioscience, 2007
The last few years have seen an explosion in the number of voltage-dependent ion channel sequences detected in sperm and testes. The complex structural paradigm of these channels is now known to include a pore-forming alpha1 subunit(s) whose electrophysiological properties are modulated by an intracellular beta subunit, a disulfide-linked complex of a ...
Susan, Benoff, Charles C, Chu, Joel L, Marmar, Rebecca Z, Sokol, Leslie O, Goodwin, Ian R, Hurley   +5 more
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In Vivo Analysis of Voltage-Dependent Calcium Channels

Journal of Bioenergetics and Biomembranes, 2003
The molecular cloning of calcium channel subunits has identified an unexpectedly large number of genes and splicing variants, many of whichhave complex expression patterns: a central problem of calcium channel biology is to understand the functional significance of this genetic complexity.
Ling, Liu, Theresa A, Zwingman, Colin F, Fletcher   +2 more
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Kupffer cells contain voltage-dependent calcium channels.

Molecular Pharmacology, 1992
Kupffer cells, the resident hepatic macrophages, are activated by calcium, but conclusive evidence that they contain voltage-dependent calcium channels has not been presented previously. In this study, the cytosolic free calcium concentration ([Ca2+]i) of cultured Kupffer cells was measured with the fluorescent Ca2+ indicator fura-2.
T, Hijioka, R L, Rosenberg, J J, Lemasters, R G, Thurman   +3 more
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Voltage dependent calcium channels in mammalian spermatozoa

Frontiers in Bioscience, 1998
Calcium influx is an absolute requirement for the physiological acrosome reaction in sperm from all sources examined, both invertebrate and mammalian. Pharmacological studies suggest that the major channel in the sperm head plasma membrane responsible for modulating calcium entry and intracellular ionized calcium levels could be either an L-type (a ...
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Voltage-dependent calcium channels: From structure to function

2005
Voltage-activated calcium channels regulate the intracellular calcium concentration and contribute thereby to calcium signalling in numerous cell types. These channels are widely distributed in the animal kingdom and are an essential part of many excitable and non-excitable mammalian cells.
F, Hofmann, L, Lacinová, N, Klugbauer
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Voltage-Dependent Calcium Channels in Glial Cells

Science, 1984
The electrophysiological properties of glial cells were examined in primary culture in the presence of tetraethylammonium and Ba 2+ , a treatment that reduces K + permeability of the membrane and enhances currents through voltage-dependent Ca 2+ channels.
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Pharmacology of voltage-dependent calcium channels

1998
Abstract Voltage-dependent calcium channels are present in the cell membranes of many cells and serve a variety of functions. In a few cell types, calcium channels play an important role in electrical activity. In many cells, though, the most important role of calcium channels is to transduce the electrical signal of an action potential ...
B P Bean, I M Mintz, L M Boland, D W Y Sah,, J A Morrill   +4 more
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