Results 251 to 260 of about 193,576 (303)

Noradrenaline contracts arteries by activating voltage-dependent calcium channels

Nature, 1988
Noradrenaline (NA) regulates arterial smooth muscle tone and hence blood vessel diameter and blood flow. NA apparently increases tone by causing a calcium influx through the cell membrane. Two calcium influx pathways have been proposed: voltage-activated calcium channels and NA-activated calcium-permeable channels that are voltage-insensitive. Although
Nelson, M. T., Standen, N. B., Brayden, J. E., Worley, J. F.   +3 more
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Genetic Analysis of Voltage-Dependent Calcium Channels

Journal of Bioenergetics and Biomembranes, 1998
Molecular cloning of calcium channel subunit genes has identified an unexpectedly large number of genes and splicing variants, and a central problem of calcium channel biology is to now understand the functional significance of this genetic complexity. While electrophyisological, pharmacological, and molecular cloning techniques are providing one level
C F, Fletcher, N G, Copeland, N A, Jenkins   +2 more
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Voltage-Dependent Calcium Channels in Plant Vacuoles

Science, 1992
Free calcium (Ca 2+ ) in the cytoplasm of plant cells is important for the regulation of many cellular processes and the transduction of stimuli. Control of cytoplasmic Ca 2+ involves the activity of pumps, carriers, and possibly ion channels. The patch-clamp technique was used to study Ca
O, Pantoja, A, Gelli, E, Blumwald
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Toxins that affect voltage-dependent calcium channels

Biochemical Pharmacology, 1987
At this time, there are five potential candidates for calcium channel specific toxins. All five of these toxins appear to affect the function of voltage-dependent calcium channels. Atrotoxin, beta-leptinotarsin-h and maitotoxin activate channels, whereas both taicatoxin and omega-conotoxin are inhibitors.
S L, Hamilton, M, Perez
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Voltage-dependent calcium channels — beyond dihydropyridine antagonists

Current Opinion in Pharmacology, 2001
The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as
T P, Snutch, K G, Sutton, G W, Zamponi
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Overview of Voltage-Dependent Calcium Channels

Journal of Bioenergetics and Biomembranes, 1998
Voltage-dependent calcium channels couple electrical signals to cellular responses in excitable cells. Calcium channels are crucial for excitation-secretion coupling in neurons and endocrine cells, and excitation-contraction coupling in muscle. Several pharmacologically and kinetically distinct calcium channel types have been identified at the ...
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Voltage-dependent Calcium Channels of Smooth Muscle Cells

Journal of Cardiovascular Pharmacology, 1988
Channels highly selective for calcium, which open when the membrane is depolarized, have been found in all smooth muscle cells examined, whether or not they can generate action potentials. The current through these channels can also be carried by barium and is blocked by cadmium, cobalt, or manganese.
T B, Bolton, I, MacKenzie, P I, Aaronson
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INVERTEBRATE VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBTYPES

Biological Reviews, 1996
82494
Skeer, JM, Norman, RI, Sattelle, DB
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Voltage‐Dependent Calcium Channel Mutations in Neurological Disease

Annals of the New York Academy of Sciences, 1999
ABSTRACT: Calcium ion channel mutations disrupt channel function and create recognizable disease phenotypes in the nervous system. The broad array of underlying cellular alterations is commensurate with the expanding genetic diversity of the voltage‐gated calcium ion channel complex and its critical role in regulating cell function.
D L, Burgess, J L, Noebels
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Acetaldehyde Inhibits Current through Voltage-Dependent Calcium Channels

Toxicology and Applied Pharmacology, 1997
Ethanol consumption is often accompanied by an increase in both cardiac and vascular dysfunction. Underlying mechanisms may include direct actions of acetaldehyde (ACA), the principal by-product of ethanol metabolism, which has previously been shown to decrease both KCl- and nonrepinephrine-elicited contractions of isolated aortic rings.
J A, Morales, J L, Ram, J, Song, R A, Brown   +3 more
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