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Voltage-dependent calcium channels in mammalian spermatozoa revisited
Frontiers in Bioscience, 2007The last few years have seen an explosion in the number of voltage-dependent ion channel sequences detected in sperm and testes. The complex structural paradigm of these channels is now known to include a pore-forming alpha1 subunit(s) whose electrophysiological properties are modulated by an intracellular beta subunit, a disulfide-linked complex of a ...
Susan, Benoff +5 more
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In Vivo Analysis of Voltage-Dependent Calcium Channels
Journal of Bioenergetics and Biomembranes, 2003The molecular cloning of calcium channel subunits has identified an unexpectedly large number of genes and splicing variants, many of whichhave complex expression patterns: a central problem of calcium channel biology is to understand the functional significance of this genetic complexity.
Ling, Liu +2 more
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Kupffer cells contain voltage-dependent calcium channels.
Molecular Pharmacology, 1992Kupffer cells, the resident hepatic macrophages, are activated by calcium, but conclusive evidence that they contain voltage-dependent calcium channels has not been presented previously. In this study, the cytosolic free calcium concentration ([Ca2+]i) of cultured Kupffer cells was measured with the fluorescent Ca2+ indicator fura-2.
T, Hijioka +3 more
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Voltage dependent calcium channels in mammalian spermatozoa
Frontiers in Bioscience, 1998Calcium influx is an absolute requirement for the physiological acrosome reaction in sperm from all sources examined, both invertebrate and mammalian. Pharmacological studies suggest that the major channel in the sperm head plasma membrane responsible for modulating calcium entry and intracellular ionized calcium levels could be either an L-type (a ...
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Voltage-dependent calcium channels: From structure to function
2005Voltage-activated calcium channels regulate the intracellular calcium concentration and contribute thereby to calcium signalling in numerous cell types. These channels are widely distributed in the animal kingdom and are an essential part of many excitable and non-excitable mammalian cells.
F, Hofmann, L, Lacinová, N, Klugbauer
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Voltage-Dependent Calcium Channels in Glial Cells
Science, 1984The electrophysiological properties of glial cells were examined in primary culture in the presence of tetraethylammonium and Ba 2+ , a treatment that reduces K + permeability of the membrane and enhances currents through voltage-dependent Ca 2+ channels.
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Pharmacology of voltage-dependent calcium channels
1998Abstract Voltage-dependent calcium channels are present in the cell membranes of many cells and serve a variety of functions. In a few cell types, calcium channels play an important role in electrical activity. In many cells, though, the most important role of calcium channels is to transduce the electrical signal of an action potential ...
B P Bean +4 more
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Extracellular Calcium Sensitivity and Voltage-Dependent Calcium Channels in C Cells*
Endocrine Reviews, 1995An essential function of C cells is to monitor [Ca2+]e and to increase CT secretion in response to small increments in [Ca2+]e. CT, in turn, decreases [Ca2+]e via its effects on bone and kidney. [Ca2+]e-dependent CT secretion is known to be mediated by corresponding changes in [Ca2+]i.
F, Raue, H, Scherübl
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PKCε upregulates voltage‐dependent calcium channels in cultured astrocytes
Glia, 2007AbstractAstrocytes express voltage‐gated calcium channels (VGCCs) that are upregulated in the context of the reactive astrogliosis occurring in several CNS pathologies. Moreover, the ability of selective calcium channel blockers to inhibit reactive astrogliosis has been revealed in a variety of experimental models. However, the functions and regulation
M, Burgos +9 more
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Molecular determinants of voltage-dependent inactivation in calcium channels
Nature, 1994Voltage-dependent Ca2+ channels respond to membrane depolarization by conformational changes that control channel opening and eventual closing by inactivation. The kinetics of inactivation differ considerably between types of Ca2+ channels and are important in determining the amount of Ca2+ entry during electrical activity and its resulting impact on ...
J F, Zhang +3 more
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