Results 21 to 30 of about 95,928 (309)

Different functions of two putative Drosophila α2δ subunits in the same identified motoneurons

Scientific Reports, 2020
Voltage gated calcium channels (VGCCs) regulate neuronal excitability and translate activity into calcium dependent signaling. The α1 subunit of high voltage activated (HVA) VGCCs associates with α2δ accessory subunits, which may affect calcium channel ...
Laurin Heinrich, Stefanie Ryglewski
doaj   +1 more source

Cinacalcet inhibition of neuronal action potentials preferentially targets the fast inactivated state of voltage-gated sodium channels

Frontiers in Physiology, 2022
Voltage-gated sodium channel (VGSC) activation is essential for action potential generation in the brain. Allosteric calcium-sensing receptor (CaSR) agonist, cinacalcet, strongly and ubiquitously inhibits VGSC currents in neocortical neurons via an ...
Jamie S. Lindner, Jamie S. Lindner, Salil R. Rajayer, Salil R. Rajayer, Briana J. Martiszus, Briana J. Martiszus, Stephen M. Smith, Stephen M. Smith   +7 more
doaj   +1 more source

Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus

Frontiers in Cellular Neuroscience, 2019
Voltage-gated ion channels are essential for signal generation and propagation in neurons and other excitable cells. The high-voltage activated calcium-channel Cav2.3 is expressed throughout the central and peripheral nervous system, and within CA1 ...
Jakob J. Gutzmann, Lin Lin, Dax A. Hoffman   +2 more
doaj   +1 more source

Voltage-dependent calcium channels in the renal microcirculation [PDF]

Nephrology Dialysis Transplantation, 2004
Voltage-dependent calcium channels (Cav) play an important role in the excitation–contraction coupling in vascular smooth muscle by linking hormoneinduced depolarization to calcium influx and contraction. In keeping with this central role of Cav, the channels are targets for pharmacological intervention in conditions such as hypertension.
Boye L, Jensen, Ulla G, Friis, Pernille B, Hansen, Ditte, Andreasen, Torben, Uhrenholt, Jeppe, Schjerning, Ole, Skøtt   +6 more
openaire   +2 more sources

Medaka as a model for ECG analysis and the effect of verapamil

Journal of Pharmacological Sciences, 2018
The heart of the medaka, a small fish native to East Asia, has electrophysiological aspects similar to mammalian hearts. We found that the heart rates of medaka were more similar to humans than mice or rats.
Manabu Yonekura, Nami Kondoh, Chong Han, Yuichi Toyama, Takayoshi Ohba, Kyoichi Ono, Shirou Itagaki, Hirofumi Tomita, Manabu Murakami   +8 more
doaj   +1 more source

A Lipid Bilayer Formed on a Hydrogel Bead for Single Ion Channel Recordings

Micromachines, 2020
Ion channel proteins play important roles in various cell functions, making them attractive drug targets. Artificial lipid bilayer recording is a technique used to measure the ion transport activities of channel proteins with high sensitivity and ...
Minako Hirano, Daiki Yamamoto, Mami Asakura, Tohru Hayakawa, Shintaro Mise, Akinobu Matsumoto, Toru Ide   +6 more
doaj   +1 more source

Gene regulation by voltage-dependent calcium channels

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Ca2+ is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca2+ in the regulation of long-term cell adaptation through its ability to control gene expression.
Barbado, Maud, Fablet, Katell, Ronjat, Michel, de Waard, Michel   +3 more
openaire   +4 more sources

Dexmedetomidine-induced contraction of isolated rat aorta is dependent on extracellular calcium concentration [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundDexmedetomidine is a highly selective α2-adrenoceptor agonist that is widely used for sedation and analgesia during the perioperative period. Intravenous administration of dexmedetomidine induces transient hypertension due to vasoconstriction ...
Seong-Ho Ok, Sung Il Bae, Haeng Seon Shim, Ju-Tae Sohn   +3 more
doaj   +1 more source

Role of the CaV1.2 distal carboxy terminus in the regulation of L-type current

Channels
L-type calcium channels are essential for the excitation-contraction coupling in cardiac muscle. The CaV1.2 channel is the most predominant isoform in the ventricle which consists of a multi-subunit membrane complex that includes the CaV1.2 pore-forming ...
Felipe Arancibia, Daniela De Giorgis, Franco Medina, Tamara Hermosilla, Felipe Simon, Diego Varela   +5 more
doaj   +1 more source

A genetic screen for dihydropyridine (DHP)-resistant worms reveals new residues required for DHP-blockage of mammalian calcium channels. [PDF]

PLoS Genetics, 2008
Dihydropyridines (DHPs) are L-type calcium channel (Ca(v)1) blockers prescribed to treat several diseases including hypertension. Ca(v)1 channels normally exist in three states: a resting closed state, an open state that is triggered by membrane ...
Trevor C Y Kwok, Kwokyin Hui, Wojciech Kostelecki, Nicole Ricker, Guillermo Selman, Zhong-Ping Feng, Peter John Roy   +6 more
doaj   +1 more source