Results 21 to 30 of about 248,505 (393)
Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes. [PDF]
PLoS ONE, 2013 Calcium-activated potassium channels of the KCa1.1 class are known to regulate repolarization of action potential discharge through a molecular association with high voltage-activated calcium channels.
Renata Rehak +5 more
doaj +1 more source
Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling
eLife, 2020 Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer +5 more
doaj +1 more source
Voltage-dependent calcium channels in the renal microcirculation [PDF]
Nephrology Dialysis Transplantation, 2004 Voltage-dependent calcium channels (Cav) play an important role in the excitation–contraction coupling in vascular smooth muscle by linking hormoneinduced depolarization to calcium influx and contraction. In keeping with this central role of Cav, the channels are targets for pharmacological intervention in conditions such as hypertension.
Pernille B. Lærkegaard Hansen +6 more
openaire +3 more sources
Inactivation of CACNA1H induces cell apoptosis by initiating endoplasmic reticulum stress in glioma
Translational Neuroscience, 2023 Ca2+ channels are abnormally expressed in various tumor cells and are involved in the progression of human glioma. Here, we explored the role of a calcium channel, voltage-dependent, T-type, alpha 1H subunit (CACNA1H), which encodes T-type Ca2+ channel ...
Liu Sheng +3 more
doaj +1 more source
Effects of cromakalim (BRL 34915) on potassium conductances in CA3 neurons of the guinea-pig hippocampus in vitro [PDF]
, 1989 The action of the potassium channel activator, cromakalim (BRL 34915), on membrane potential, input resistance and current-voltage-relationship of CA3 neurons in a slice preparation of the guinea-pig hippocampus was investigated by means of intracellular
Alzheimer, Christian +2 more
core +1 more source
A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels
Molecular Brain, 2021 A novel missense mutation in the CACNA1A gene that encodes the pore forming α1 subunit of the CaV2.1 voltage-gated calcium channel was identified in a patient with trigeminal neuralgia.
Eder Gambeta +4 more
doaj +1 more source
The roles of the subunits in the function of the calcium channel [PDF]
, 1991 Dihydropyridine-sensitive voltage-dependent L-type calcium channels are critical to excitation-secretion and excitation-contraction coupling. The channel molecule is a complex of the main, pore-forming subunit alpha 1 and four additional subunits: alpha ...
Biel, Martin +5 more
core +1 more source
A chloride channel in rat and human axons [PDF]
, 1991 Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at ...
Baker +19 more
core +1 more source
Voltage-dependent inactivation of a calcium channel. [PDF]
Proceedings of the National Academy of Sciences, 1981 The inactivation of Ca currents in unfertilized eggs of the marine polychaete Neanthes arenaceodentata was investigated by using a voltage clamp technique. These Ca currents do not appear to be masked by other currents in the voltage range studied.
openaire +3 more sources
Voltage-dependent calcium channel in the squid axon. [PDF]
Proceedings of the National Academy of Sciences, 1983 A voltage-dependent inward calcium current insensitive to tetrodotoxin has been measured in internally perfused or dialyzed squid giant axons. Sodium conductance was blocked by tetrodotoxin, and potassium conductance was irreversibly destroyed by the lack of potassium in the external and internal medium.
R DiPolo +2 more
openaire +3 more sources