Results 141 to 150 of about 63,537 (256)

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, EarlyView.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch. [PDF]

PLoS One
Braz JM, Jewell M, Bhardwaj K, Rodriguez-Rosado S, Craik V, Basbaum AI.   +5 more
europepmc   +1 more source

Small Molecules as Modulators of Voltage-Gated Calcium Channels in Neurological Disorders: State of the Art and Perspectives. [PDF]

Molecules, 2022
Lanzetti S, Di Biase V.
europepmc   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

Degradation of voltage-gated calcium channels: mechanisms and applications in neurological and cardiovascular diseases. [PDF]

Cell Commun Signal
Liu L, Zhou Y, Liao P, Soong TW, Hu Z.
europepmc   +1 more source

Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain. [PDF]

Neurobiol Pain, 2023
Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R.   +10 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Differential contribution of T-type voltage-gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits. [PDF]

Exp Physiol
Suarez A, Guerra-Ojeda S, Zarzoso M, Serna-García M, Vila JM, Serna E, Mauricio MD.   +6 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Crotoxin B from the South American Rattlesnake <i>Crotalus vegrandis</i> Blocks Voltage-Gated Calcium Channels Independent of Its Intrinsic Catalytic Activity. [PDF]

Toxins (Basel)
Eicheldinger M, Miranda-Laferte E, Castilla F, Jordan N, Santiago-Schübel B, Hidalgo P.   +5 more
europepmc   +1 more source