Results 271 to 280 of about 157,979 (315)
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On the opening of voltage-gated ion channels
Physiology & Behavior, 2007Voltage-gated ion channels are key players in fast neuronal signalling. Detailed knowledge about channel gating is essential for our understanding of channel function in general and of drug action of channels in particular. Despite a number of recent atomic channel structures, the opening of voltage-gated channels is the subject of heated debates. Here
Fredrik, Elinder +2 more
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Voltage-Gated Sodium Channels and Hyperalgesia
Annual Review of Pharmacology and Toxicology, 2004Physiological and pharmacological evidence both have demonstrated a critical role for voltage-gated sodium channels (VGSCs) in many types of chronic pain syndromes because these channels play a fundamental role in the excitability of neurons in the central and peripheral nervous systems. Alterations in function of these channels appear to be intimately
Josephine, Lai +3 more
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2008
How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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How and where simple volatile organic molecules act in the central nervous system to cause loss of consciousness and insensitivity to pain has eluded investigation; yet remarkable progress has been made recently towards identifying possible molecular targets through which the mechanism of anesthesia is tranduced.
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Voltage-gated calcium channels and disease
BioFactors, 2011Voltage-gated calcium channels are a family of integral membrane calcium-selective proteins found in all excitable and many nonexcitable cells. Calcium influx affects membrane electrical properties by depolarizing cells and generally increasing excitability.
Stuart M, Cain, Terrance P, Snutch
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The kinetics of voltage-gated ion channels
Quarterly Reviews of Biophysics, 1994When Hodgkin & Huxley (1952) first embarked on the analysis of their voltageclamp data on the ionic currents in the squid giant axon, they hoped to be able to deduce a mechanism from it, but it soon became clear that the electrical data would by themselves yield only very general information about the class of system likely to be involved.
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Ubiquitylation of Voltage-Gated Sodium Channels
2014Ion channel proteins are regulated by different types of posttranslational modifications. The focus of this review is the regulation of voltage-gated sodium channels (Navs) upon their ubiquitylation. The amiloride-sensitive epithelial sodium channel (ENaC) was the first ion channel shown to be regulated upon ubiquitylation.
Laedermann, Cédric J +2 more
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2020
This chapter describes the main properties of a voltage-dependent channel presented firstly as a prototype of conducting channels, that is, pore-forming molecules managing transient transmembrane ion fluxes. At resting potential, the voltage sensor adopts a depolarized conformation, and the pore is closed.
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This chapter describes the main properties of a voltage-dependent channel presented firstly as a prototype of conducting channels, that is, pore-forming molecules managing transient transmembrane ion fluxes. At resting potential, the voltage sensor adopts a depolarized conformation, and the pore is closed.
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Diversity of voltage gated proton channels
Frontiers in Bioscience, 2003Voltage gated proton channels were first discovered in snail neurons and recently have been found in many mammalian cells. As their name suggests, H+ channels are sensitive to voltage, with an open probability that increases with membrane depolarization.
Deri, Morgan, Thomas E, DeCoursey
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Thermodynamics of a voltage-gated potassium channel
Physical Review EIn order to know how a single potassium channel works in its microscopic niche, a hybrid process about the observables of channel state and voltage is constructed, which comprises the interweaving kinetics of channel gating, voltage decay, and thermal noise. The formula of entropy production rates (i.e., power dissipation) is derived and the stationary
Jia-Zeng Wang +3 more
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Voltage-Gated Calcium Channels in Nociception
2008Voltage-gated calcium channels (VGCCs) are a large and functionally diverse group of membrane ion channels ubiquitously expressed throughout the central and peripheral nervous systems. VGCCs contribute to various physiological processes and transduce electrical activity into other cellular functions.
Yasuda, T., Adams, D. J.
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