Results 281 to 290 of about 157,979 (315)

A Prokaryotic Voltage-Gated Sodium Channel

Science, 2001
The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. The sequence,
D, Ren, B, Navarro, H, Xu, L, Yue, Q, Shi, D E, Clapham   +5 more
openaire   +2 more sources

The voltage-gated potassium channels and their relatives

Nature, 2002
The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration.
openaire   +2 more sources

Voltage Gated Ion Channels and Sleep

The Journal of Membrane Biology
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal excitability, synaptic transmission and plasticity. Dysfunction in these channels, such as improper expression or localization, can lead to irregular neuronal excitability and synaptic communication, which may manifest as various ...
Yan, Zhang, Jiawen, Wu, Yuxian, Zheng, Yangkun, Xu, Ziqi, Yu, Yong, Ping   +5 more
openaire   +2 more sources

Pharmacology of Voltage-Gated Proton Channels

Current Pharmaceutical Design, 2007
Voltage-gated proton channels are highly proton selective ion channels that are present in many cells. Although their unitary conductance is 1000 times smaller than that of most ion channels, detection of single-channel currents supports their identification as channels rather than carriers.
Thomas E, DeCoursey, Vladimir V, Cherny
openaire   +2 more sources

Voltage-Gated Sodium Channels and Pain

Current Drug Target -CNS & Neurological Disorders, 2004
Voltage-gated sodium channels are highly specialized molecular transducers that play a significant role in the creation and transmission of electrical activity throughout the neuraxis. These ion channels are fundamentally involved in sensory neuron physiology and pathophysiology; a complete but localized suspension of their normal function can prevent ...
openaire   +2 more sources

Evolution of voltage-gated Na+ channels

Journal of Experimental Biology, 2002
SUMMARY Voltage-gated Na+ channels play important functional roles in the generation of electrical excitability in most vertebrate and invertebrate species. These channels are members of a superfamily that includes voltage-gated K+, voltage-gated Ca2+ and cyclic-nucleotide-gated channels.
openaire   +2 more sources

Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes

Molecular Cell, 2022
Wenlei Ye, Hongtu Zhao, Yingdi Wang
exaly  

A review of a new voltage-gated Ca 2+ channel α 2 δ ligand, mirogabalin, for the treatment of peripheral neuropathic pain

Expert Opinion on Pharmacotherapy, 2021
Jitsu Kato, Teruyoshi Inoue, Mizuka Yokoyama   +2 more
exaly  

Hunting for the pore of voltage-gated channels

Current Biology, 1992
C, Miller, H, Hughes
openaire   +2 more sources

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

Cell, 2019
Goragot Wisedchaisri, Lige Tonggu, Tamer M Gamal El-Din   +2 more
exaly