Results 91 to 100 of about 238,298 (223)

The envenomation of general physiology throughout the last century. [PDF]

, 2017
Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
core   +1 more source

CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons [PDF]

, 2007
The inhibitor cystine-knot motif identified in the structure of CSTX-1 from Cupiennius salei venom suggests that this toxin may act as a blocker of ion channels.
Beirão, PSL, Boehm, S, Chong, Y, Cruz, JS, Kubista, H, Kuhn-Nentwig, L, Mafra, RA, Nentwig, W, Nicholson, GM   +8 more
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Idiopathic Generalized Epilepsy and Hypokalemic Periodic Paralysis in a Family of South Indian Descent

Case Reports in Neurological Medicine, 2015
Inherited channelopathies are a heterogeneous group of disorders resulting from dysfunction of ion channels in cellular membranes. They may manifest as diseases affecting skeletal muscle contraction, the conduction system of the heart, nervous system ...
Muthiah Subramanian, N. Senthil, S. Sujatha   +2 more
doaj   +1 more source

Subthreshold Voltage Noise Due to Channel Fluctuations in Active Neuronal Membranes [PDF]

, 1999
Voltage-gated ion channels in neuronal membranes fluctuate randomly between different conformational states due to thermal agitation. Fluctuations between conducting and nonconducting states give rise to noisy membrane currents and subthreshold voltage ...
Amit Manwani, Christof Koch, Idan Segev, K, Michael London, Peter N. Steinmetz   +5 more
core   +3 more sources

A Quantum-mechanical description of ion motion within the confining potentials of voltage gated ion channels

, 2012
Voltage gated channel proteins cooperate in the transmission of membrane potentials between nerve cells. With the recent progress in atomic-scaled biological chemistry it has now become established that these channel proteins provide highly correlated ...
Bernroider G., Bernroider G., Briegel H. J., Corry B., Gustav Bernroider, Johann Summhammer, Thomas J. W., Vahid Salari   +7 more
core   +2 more sources

Conotoxins Targeting Voltage-Gated Sodium Ion Channels

Pharmacological Reviews
Voltage-gated sodium (NaV) channels are intimately involved in the generation and transmission of action potentials, and dysfunction of these channels may contribute to nervous system diseases, such as epilepsy, neuropathic pain, psychosis, autism, and cardiac arrhythmia. Many venom peptides selectively act on NaV channels.
Shengrong Pei, Nan Wang, Zaoli Mei, Dongting Zhangsun, David J. Craik, J. Michael McIntosh, Xiaopeng Zhu, Sulan Luo   +7 more
openaire   +2 more sources

M‐type K⁺ channels in peripheral nociceptive pathways

, 2018
Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain, we need to develop a mechanistic insight into the key ion ...
Abd-Elsayed, Alexander, Alexander, Alexander, Alexander, Amir, Anonymous, Bandell, Barkai, Bentzen, Bernal, Bierbower, Breivik, Breyer, Brown, Brueggemann, Bushell, Cai, Campbell, Chen, Cisneros, Couture, Crozier, Cruzblanca, Dalby-Brown, Daniluk, Davoren, Debanne, Delmas, Devaux, Devor, Devor, Devulder, Dray, Du, Du, Fawcett, Ferrero-Miliani, Filippov, Fritch, Gamper, Gamper, Gamper, Gamper, Gao, Gao, Gemes, Govrin-Lippmann, Greene, Gribkoff, Grunnet, Ha, Hayashi, Heidenreich, Hernandez, Hille, Hirano, Hoheisel, Hoshi, Huang, Huang, Huang, Iannotti, Jentsch, Jia, Jin, Kanda, Keele, King, King, Kolosov, Kosenko, Kuhn, Kumar, L'Heureux, Lang, Laumet, Lee, Li, Linley, Linley, Linley, Linley, Liu, Liu, Luscher, Miceli, Mucha, Munro, O'Connor, Ooi, Ooi, Passmore, Passmore, Peiris, Peretz, Peretz, Peretz, Petho, Prinsloo, Qi, Rivera-Arconada, Rivera-Arconada, Rose, Roza, Roza, Schenzer, Schroeder, Schutze, Serhan, Shapiro, Southan, Stafstrom, Stoney, Stott, Sugiura, Suh, Suh, Sundt, Tatulian, Tatulian, Teng, Uchida, Vetter, Visockis, Wall, Wang, Wang, Wickenden, Wickenden, Willis, Wladyka, Wood, Wu, Wu, Wu, Wu, Wuttke, Xiong, Xu, Zaika, Zaika, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zheng   +148 more
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Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

Diabetes, 2010
OBJECTIVE To document the properties of the voltage-gated ion channels in human pancreatic α-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS Glucagon release was measured from intact islets.
R. Ramracheya, C. Ward, M. Shigeto, Jonathan N. Walker, S. Amisten, Quan Zhang, P. Johnson, P. Rorsman, M. Braun   +8 more
semanticscholar   +1 more source

Isolated pores dissected from human two-pore channel 2 are functional [PDF]

Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the
Miles, A.J., Patel, S., Penny, C.J., Rahman, T., Sula, A., Wallace, Bonnie A.   +5 more
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Voltage gating of mechanosensitive PIEZO channels

Nature Communications, 2018
PIEZO proteins form mechanosensitive ion channels. Here the authors present electrophysiological measurements that show that PIEZO channels are also modulated by voltage and can switch to a purely voltage gated mode, which is an evolutionary conserved ...
Mirko Moroni, M. Rocio Servin-Vences, Raluca Fleischer, Oscar Sánchez-Carranza, Gary R. Lewin   +4 more
doaj   +1 more source