Results 151 to 160 of about 238,298 (223)

Voltage-Gated Sodium Ion Channel Activation [PDF]

, 2020
openaire   +1 more source

Pathophysiology of homocysteine: insights into ion channel dysfunction. [PDF]

Pflugers Arch
Chmúrčiaková N, Stringer RN, Cmarko L, Filipova A, Lacinova L, Weiss N.   +5 more
europepmc   +1 more source

Spectrum and functions of ion channels and transporters in osteoclasts. [PDF]

Bone Res
Chen H, Zhang Y, Zhu Y, Xiao X, Huang S, Duan X.   +5 more
europepmc   +1 more source

Polypharmacology of anthelmintics at host and parasite ion channels. [PDF]

PLoS Pathog
Chan JD, Ericksen SS, Zamanian M.
europepmc   +1 more source

Modular Model of Neuronal Activity That Captures the Dynamics of Main Molecular Targets of Antiepileptic Drugs. [PDF]

Int J Mol Sci
Kondrakhin PY, Kolpakov FA.
europepmc   +1 more source

Special Issue "Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation 2.0. [PDF]

Int J Mol Sci
Guerrini G, Giovannoni MP.
europepmc   +1 more source

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Voltage-Gated Ion Channels and Hereditary Disease

Physiological Reviews, 1999
By the introduction of technological advancement in methods of structural analysis, electronics, and recombinant DNA techniques, research in physiology has become molecular. Additionally, focus of interest has been moving away from classical physiology to become increasingly centered on mechanisms of disease.
F, Lehmann-Horn, K, Jurkat-Rott
openaire   +3 more sources

Structure and Function of Voltage-Gated Ion Channels

Annual Review of Biochemistry, 1993
The principal subunits of the voltage-gated Na+, Ca2+ and K+ channels are members of a related gene family and are functionally autonomous in voltage-dependent activation, ion conductance and inactivation. In this article, recent work locating the structural elements that are responsible for these three basic functions of the voltage-gated ion channels
W. Catterall
openaire   +4 more sources

Structural biology and molecular pharmacology of voltage-gated ion channels

Nature Reviews Molecular Cell Biology
Jian Huang, Xiaojing Pan, Nieng Yan
semanticscholar   +3 more sources

Drug Development in Channelopathies: Allosteric Modulation of Ligand-Gated and Voltage-Gated Ion Channels.

Journal of Medicinal Chemistry, 2020
Ion channels have been characterized as promising drug targets for treatment of numerous human diseases. Functions of ion channels can be fine-tuned by allosteric modulators, which interact with channels and modulate their activities by binding to sites ...
Yanyun Zhang, Ke Wang, Zhiyi Yu
semanticscholar   +1 more source