Results 81 to 90 of about 238,298 (223)

Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization

Nature Communications, 2023
Ion channels function within a membrane environment characterized by dynamic lipid compartmentalization. Limited knowledge exists regarding the response of voltage-gated ion channels to transmembrane potential within distinct membrane compartments.
Lucas J. Handlin, Gucan Dai
doaj   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Bowden, S, Brust, A, Cesare, P, Colless, B, Drew, LJ, Gale, JE, Heinzmann, S, Lewis, RJ, Robinson, M, Rugiero, F, Wood, JN   +11 more
core  

Coupled Movements in Voltage-gated Ion Channels [PDF]

The Journal of General Physiology, 2002
Ion channels, like most other proteins, are designed to move. To preserve ionic gradients across cell membranes, they are usually closed and open their gates only when called upon to do electric work.
openaire   +2 more sources

Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons

Frontiers in Cell and Developmental Biology
Transient Receptor Potential (TRP) ion channels like Vanilloid 1 (TRPV1) and Melastatin 3 (TRPM3) are nonselective cation channels expressed in primary sensory neurons and peripheral nerve endings, which are located in cholesterol- and sphingolipid-rich ...
Maja Payrits, Maja Payrits, Maja Payrits, Balázs Zoltán Zsidó, Balázs Zoltán Zsidó, Andrea Kinga Nehr-Majoros, Andrea Kinga Nehr-Majoros, Andrea Kinga Nehr-Majoros, Rita Börzsei, Rita Börzsei, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Csaba Hetényi, Csaba Hetényi, Éva Szőke, Éva Szőke, Éva Szőke   +17 more
doaj   +1 more source

Voltage-Gated K+/Na+ Channels and Scorpion Venom Toxins in Cancer

Frontiers in Pharmacology, 2020
Ion channels have recently been recognized as novel therapeutic targets in cancer research since they are overexpressed in different histological tissues, and their activity is linked to proliferation, tumor progression, angiogenesis, metastasis, and ...
Alexis Díaz-García, Alexis Díaz-García, Diego Varela, Diego Varela   +3 more
doaj   +1 more source

Molecular basis of ion permeability in a voltage-gated sodium channel [PDF]

, 2016
Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other cations, enabling the finely tuned cascade of events associated with action potentials.
Altin Sula, Antonella Scaglione, BA Wallace, Bricogne G, Claire Bagnéris, Claire E Naylor, David E Clapham, Eswar N, Evans PR, Kabsch W, Paul G DeCaen, Zhang X   +11 more
core   +2 more sources

Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules [PDF]

, 2007
Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions.
Georgiev, Danko, Glazebrook, James, Papaioanou, Stelios   +2 more
core   +1 more source

The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

Frontiers in Cellular Neuroscience, 2017
Neurons are highly polarized cells with apparent functional and morphological differences between dendrites and axon. A critical determinant for the molecular and functional identity of axonal and dendritic segments is the restricted expression of ...
Jeffrey Lopez-Rojas, Maël Duménieu, Marie Oulé, Michael R. Kreutz, Michael R. Kreutz   +4 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Voltage-dependent gating in a "voltage sensor-less" ion channel.

PLoS Biology, 2010
The voltage sensitivity of voltage-gated cation channels is primarily attributed to conformational changes of a four transmembrane segment voltage-sensing domain, conserved across many levels of biological complexity.
Harley T Kurata, Markus Rapedius, Marc J Kleinman, Thomas Baukrowitz, Colin G Nichols   +4 more
doaj   +1 more source