Results 201 to 210 of about 59,499 (256)

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Development and characterization of the mode-of-action of inhibitory and agonist peptides targeting the voltage-gated sodium channel SCN1B beta-subunit. [PDF]

J Mol Cell Cardiol
Williams ZJ, Alvarez-Laviada A, Hoagland D, Jourdan LJ, Poelzing S, Gorelik J, Gourdie RG.   +6 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Quercetin, Main Active Ingredient of Moutan Cortex, Alleviates Chronic Orofacial Pain via Block of Voltage-Gated Sodium Channel. [PDF]

Anesth Analg
Liu Z, Shan Z, Yang H, Xing Y, Guo W, Cheng J, Jiang Y, Cai S, Wu C, Liu JA, Cheung CW, Pan Y.   +11 more
europepmc   +1 more source

Metabolic Resistance and Not Voltage-Gated Sodium Channel Gene Mutation Is Associated with Pyrethroid Resistance of Aedes albopictus (Skuse, 1894) from Cambodia. [PDF]

Insects
Marcombe S, Doeurk B, Thammavong P, Veseli T, Heafield C, Mills MA, Kako S, Prado MF, Thomson S, Millett S, Hill T, Kentsley I, Davies S, Pathiraja G, Daniels B, Browne L, Nyamukanga M, Harvey J, Rubinstein L, Townsend C, Allen Z, Davey-Spence C, Hupi A, Jones AK, Boyer S.   +24 more
europepmc   +1 more source

Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating

Hollingworth D, Herold KF, Kelly G, Mykhaylyk VB, Zhang D, Wallace BA, Hemmings HC.   +6 more
europepmc   +1 more source

Isoform-specific N-linked glycosylation of voltage-gated sodium channel alpha-subunits alters beta-subunit binding sites

Beaudoin CA, Kohli M, Salvage SC, Liu H, Arundel SJ, Hamaia SW, Lei M, Huang CL, Jackson AP.   +8 more
europepmc   +1 more source

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Voltage-gated sodium channels

Current Opinion in Pharmacology, 2015
Voltage-gated sodium channels play a key role in the transmission of sensory information about the status of organs in the periphery. Sensory fibers contain a heterogeneous yet specific distribution of voltage-gated sodium channel isoforms. Major efforts by industry and academic groups are underway to develop medicines that interrupt inappropriate ...
Kevin, Kwong, Michael J, Carr
openaire   +3 more sources