Results 141 to 150 of about 59,574 (256)

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABA_A Receptor and Voltage-Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies. [PDF]

Brain Behav
Mia E, Rahman MA, Shipon MNH, Mou MA, Mandal P, Rakib IH, Sayeed MA, Islam MT, Al Hasan MS, Ansari MA.   +9 more
europepmc   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Correction: Kdr genotyping and the first report of V410L and V1016I kdr mutations in voltage-gated sodium channel gene in Aedes aegypti (Diptera: Culicidae) from Iran. [PDF]

Parasit Vectors
Enayati A, Valadan R, Bagherzadeh M, Cheraghpour M, Nikookar SH, Fazeli-Dinan M, Hosseini-Vasoukolaei N, Rostami FS, Kordshouli RS, Raeisi A, Nikpour F, Mirolyaei A, Bagheri F, Sedaghat MM, Zaim M, Weetman D, Hemigway J.   +16 more
europepmc   +1 more source

Molecularly Engineered Wing‐Shaped Azobenzene Memristors for Logic‐in‐Memory and Edge Visual Intelligence

Advanced Science, EarlyView.
Rational engineering of terminal substituents in symmetric azobenzene‐based molecules enables precise control over conformationally coupled charge‐transfer processes. This design yields tunable nonvolatile resistive memory behaviors, ranging from write‐once‐read‐many‐times (WORM) to rewritable switching.
Yanze Liu, Tao Han, Jiahui Ding, Hong Lian, Lingling Yao, Zhaoxin Xu, Xingyu Zhang, Shuanglong Wang, Jiangnan Xia, Tianchi Zhang, Weiwei Kang, Qingchen Dong   +11 more
wiley   +1 more source

High voltage-gated sodium channel gene diversity in Aedes albopictus across Brazil. [PDF]

Sci Rep
Nascimento GJ, Cosme LV, Torres ALQ, Lima JBP, Martins AJ.   +4 more
europepmc   +1 more source

Role of the voltage‑gated sodium channel Nav1.6 in glioma and candidate drugs screening. [PDF]

Int J Mol Med, 2023
Ai Y, Zhang X, Hu X, Gao J, Liu J, Ou S, Wang J.   +6 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Voltage-Gated Sodium Channel, as an Ion Channel in Therapeutics: A Bibliometric Analysis of Global Trends (1984-2023). [PDF]

Malays J Med Sci
Mohd Noor MR, Jamaludin SYN, Senik MH, Abdul Aziz MY.   +3 more
europepmc   +1 more source

Author Correction: Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. [PDF]

Nat Commun, 2023
Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, Yang R, Pan M, Landstrom AP, Henriquez C, Bursac N.   +10 more
europepmc   +1 more source