Results 161 to 170 of about 115,275 (296)

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Surveillance of pyrethroid resistance and detection of voltage-gated sodium channel gene mutations in Aedes albopictus populations from Shanghai, China. [PDF]

Parasit Vectors
Qian K, Dai Y, Qin S, Wang Y, Meng X, Wang J, Liu H.   +6 more
europepmc   +1 more source

Role of the voltage‑gated sodium channel Nav1.6 in glioma and candidate drugs screening. [PDF]

Int J Mol Med, 2023
Ai Y, Zhang X, Hu X, Gao J, Liu J, Ou S, Wang J.   +6 more
europepmc   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

High voltage-gated sodium channel gene diversity in Aedes albopictus across Brazil. [PDF]

Sci Rep
Nascimento GJ, Cosme LV, Torres ALQ, Lima JBP, Martins AJ.   +4 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Voltage-Gated Sodium Channel, as an Ion Channel in Therapeutics: A Bibliometric Analysis of Global Trends (1984-2023). [PDF]

Malays J Med Sci
Mohd Noor MR, Jamaludin SYN, Senik MH, Abdul Aziz MY.   +3 more
europepmc   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, EarlyView.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Na_v1.7 by Two Novel Arachnid Toxins. [PDF]

Toxins (Basel)
Johnson JW, Rikli HG, Johnson SR.
europepmc   +1 more source

Scanning mutagenesis of the voltage-gated sodium channel Na_V1.2 using base editing. [PDF]

Cell Rep, 2023
Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL, Pan JQ.   +12 more
europepmc   +1 more source