Results 201 to 210 of about 66,157 (301)

Thermally Processable, Transparent, Mechanically Tunable and Robust Bioplastics From Wastepaper

Advanced Science, EarlyView.
Unlike conventional inefficient or low‐value wastepaper recycling, a directional transformation strategy is employed to convert whole wastepaper into intact bioplastics with tunable mechanical properties in our work. These bioplastics can be processed into flexible bags or rigid containers and exhibit high transparency, water resistance, repairability,
Zhezhe Zhou, Tao Chu, Boyou Hou, Mark Lynch, Siqi Huo, Min Hong, Jianguo Yang, Paulomi (Polly) Burey, Qiang Gao, Guobo Huang, Pingan Song   +10 more
wiley   +1 more source

The local anesthetic, lidocaine, suppresses the growth of colon cancer SW480 cells by decreasing the voltage-gated sodium channel subunit Na_v1.5. [PDF]

Sci Rep
Haraguchi-Suzuki K, Suzuki T, Nakasone C, Kawabata-Iwakawa R, Saito S.   +4 more
europepmc   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Effects of natural Lithium and Lithium isotopes on voltage gated sodium channel activity in SH-SY5Y and IPSC derived cortical neurons. [PDF]

Sci Rep
Bukhteeva I, Livingstone JD, Singh K, Pavlov EV, Beazely MA, Gingras MJP, Leonenko Z.   +6 more
europepmc   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Mutations in the voltage-gated sodium channel associated with permethrin resistance in Rhipicephalus linnaei populations in Thailand. [PDF]

Sci Rep
Takhampunya R, Ngonsawan W, Longkunan A, Phasomkusolsil S, Promsathaporn S, Tippayachai B, Sakolvaree J, Mann AN, Lindroth EJ.   +8 more
europepmc   +1 more source

In Situ Confinement of 0D Halometallates Within Deep Eutectic Solvents: From Systematic Screening to Metal‐Tunable Luminescence for Anti‐Counterfeiting Eutectogels

Advanced Science, EarlyView.
We report photostable, photoluminescent deep eutectic solvents (DESs) powered by in situ‐formed zero‐dimensional (0D) halometallates. Stabilized by microenvironment‐controlling hydrogen bond acceptor (HBA) and donor (HBD) networks, these DESs exhibit vibrant, metal ion‐tunable emission (PLQY = 60.2%).
Jeesu Moon, Minkyu Jung, Woojin Jung, Jaeyune Ryu, Jae‐Seung Lee   +4 more
wiley   +1 more source

L-quebrachitol Modulates the Anti-convulsant Effects of Carbamazepine Possibly Through Voltage-gated Sodium Channel Blocking Mechanism in Chicks: In Vivo and In Silico Studies. [PDF]

Brain Behav
Asrafi A, Aslam M, Alkhathami AG, Hossain MS, Rakib IH, Al Hasan MS, Nun FK, Amin MF, Islam MT.   +8 more
europepmc   +1 more source

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

The Plant Alkaloid Harmaline Blocks the Voltage-Gated Sodium Channel Na_v1.7: A Study Using an Automated Patch-Clamp. [PDF]

Int J Mol Sci
Eisfeld J, Schumacher M, Krautwald M, Wierschke S, Qin L, Fechtali T, Brinkmeier H.   +6 more
europepmc   +1 more source