Results 61 to 70 of about 59,574 (256)

Voltage-gated sodium channels and metastatic disease [PDF]

Channels, 2012
Voltage-gated Na (+) channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSCs are expressed in metastatic cells from a number of cancers. In these cells, Na (+) current carried by α subunits enhances migration, invasion and metastasis in vivo.
openaire   +4 more sources

Boolean Logic‐Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery

Advanced Materials, EarlyView.
Fully recombinant protein‐based biomaterials execute complex Boolean logic for user‐programmable material degradation and concomitant therapeutic cargo release. Biologics, such as growth factors, can be incorporated within the crosslinkers as “drugamers”, while encapsulated cells can be released according to nested YES/OR/AND‐type logical operations ...
Murial L. Ross, Ryan Gharios, Shivani Kottantharayil, Cole A. DeForest   +3 more
wiley   +1 more source

Structure and function of voltage‐gated sodium channels

The Journal of Physiology, 1998
Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. Sodium channels have a modular architecture, with distinct regions for the pore and the gates.
E, Marban, T, Yamagishi, G F, Tomaselli
openaire   +3 more sources

Voltage-gated sodium channels assemble and gate as dimers

Nature Communications, 2017
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this ...
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes   +9 more
doaj   +1 more source

Differential lipid dependence of the function of bacterial sodium channels.

PLoS ONE, 2013
The lipid bilayer is important for maintaining the integrity of cellular compartments and plays a vital role in providing the hydrophobic and charged interactions necessary for membrane protein structure, conformational flexibility and function.
Nazzareno D'Avanzo, Emily C McCusker, Andrew M Powl, Andrew J Miles, Colin G Nichols, B A Wallace   +5 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

Computational drug repositioning approach to predict multi-target therapeutics for epilepsy

Scientific Reports
Epilepsy affects millions of people globally, with approximately one-third of patients experiencing drug-resistant seizures. Developing new anti-epileptic drugs is time-intensive and costly, prompting interest in computational drug repositioning ...
Pawan Kumar, Vivek Kumar, Raveena Chauhan, Vandana Saini, Ajit Kumar   +4 more
doaj   +1 more source

Sustainable and Multifunctional Natural Macromolecular Polymers for Aqueous Zn Metal Batteries

Advanced Materials, EarlyView.
We comprehensively review the structure‐function relationships and regulatory mechanism of natural macromolecular polymers in stabilizing zinc anodes at the microscopic and mesoscopic scales. The interactions among polymer structures, optimization strategies, and regulatory mechanisms are discussed systematically summarizing recent related research ...
Yunuo Shi, Bo Jiang, Jingcheng Zhang, Xiaodong Shao, Peixun Xiong, Lutong Shan, Shengyang Huang, Mengfang Liang, Mengyao Chang, Fangyan Liu, Wenwu Li, Baoyu Xia, Wei Ji, Ho Seok Park   +13 more
wiley   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source