Results 181 to 190 of about 59,509 (256)

Scanning mutagenesis of the voltage-gated sodium channel Na_V1.2 using base editing. [PDF]

Cell Rep
Pablo JLB, Cornett SL, Wang LA, Jo S, Brünger T, Budnik N, Hegde M, DeKeyser JM, Thompson CH, Doench JG, Lal D, George AL, Pan JQ.   +12 more
europepmc   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

V1848I Mutation in the Voltage-Gated Sodium Channel Confers High-Level Resistance to Indoxacarb and Metaflumizone in Spodoptera exigua. [PDF]

Insects
Liu X, Cao M, Mei W, Wang X, Wu Y.
europepmc   +1 more source

Solvent Oxidation‐Directed Synthesis of Highly Crystalline Iron Oxide Nanoparticles With Near‐Bulk Magnetization

Advanced Science, EarlyView.
Controlled oxidation of benzyl ether is established as a key synthetic parameter in the thermal decomposition of iron(III) acetylacetonate. Oxygenated solvent species alter precursor coordination and nucleation–growth kinetics, producing highly crystalline, magnetite‐rich nanoparticles with tunable size, controlled morphology, and near‐bulk ...
Lukas Hertle, Valentin Gantenbein, Joaquim Llacer‐Wintle, Mingchen Ma, Ziyu Li, Pu Luo, Zhengwei Tan, Fei Chen, Chen Chen, Chuanyi Wu, Chenxin Gao, Chenyi Zhou, Carlos Franco, Pere Bruna, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Bradley J. Nelson, Salvador Pané   +17 more
wiley   +1 more source

First detection of the S989P+V1016G+D1763Y haplotype and expansion of voltage-gated sodium channel mutations in Aedes aegypti in Taiwan in 2016-2023. [PDF]

PLoS Negl Trop Dis
Chung HH, Teng HJ, Huang CG, Tsai IJ, Chen HJ, Komagata O, Kasai S, Tsai KH, Chen SL.   +8 more
europepmc   +1 more source

Ion Superhighways in a Hierarchical Polymer‐Ceramic Membrane Enable Rapid and Selective Lithium Extraction

Advanced Science, EarlyView.
A flexible PDMS‐LATP polymer‐ceramic membrane creates lithium‐ion “superhighways” for rapid and selective extraction from complex brines. The amorphous PDMS matrix suppresses nonselective leakage and stabilizes the ceramic network, while LATP provides preferential Li+ conduction.
Xinxin Wei, Jiawei Sun, Min Wei Boey, Xiaolu Li, Minji Kim, Junghwan Kim, Hongjiang Chen, Patrick H.‐L. Sit, Yixiang Wang, Zhigang Li, Ze‐Xian Low, Jason Chun‐Ho Lam, Alicia Kyoungjin An   +12 more
wiley   +1 more source

Therapeutic targeting of voltage-gated sodium channel Na_V1.7 for cancer metastasis. [PDF]

Front Pharmacol
Pukkanasut P, Jaskula-Sztul R, Gomora JC, Velu SE.   +3 more
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias? [PDF]

Heart Rhythm
Williams ZJ, Payne LB, Wu X, Gourdie RG.
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source