Results 221 to 230 of about 59,509 (256)

Voltage-gated sodium channels as therapeutic targets

Drug Discovery Today, 2000
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in neurons and other cells. VGSC modulators have their origins in empirical pharmacology and are being used as local anaesthetics, antiarrhythmics, analgesics and antiepileptics, and for other disorders.
, Clare, , Tate, , Nobbs, , Romanos
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Diversity of Mammalian Voltage‐Gated Sodium Channels

Annals of the New York Academy of Sciences, 1999
ABSTRACT: A variety of different isoforms of mammalian voltage‐gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart.
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Voltage Gated Sodium Channels

2014
Overview: biophysical properties and structure of sodium channels.- The voltage sensor module in sodium channels.- Slow inactivation of Na+ channels.- Regulation/modulation of sensory neuron sodium channels.- Ubiquitylation of voltage-gated sodium channels.- Probing gating mechanisms of sodium channel using pore blockers.- Animal toxins influence ...
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Voltage‐gated sodium channels and pain pathways

Journal of Neurobiology, 2004
AbstractAcute, inflammatory, and neuropathic pain can all be attenuated or abolished by local treatment with sodium channel blockers such as lidocaine. The peripheral input that drives pain perception thus depends on the presence of functional voltage‐gated sodium channels.
John N, Wood, James P, Boorman, Kenji, Okuse, Mark D, Baker   +3 more
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Evolutionary History of Voltage-Gated Sodium Channels

2017
Every cell within living organisms actively maintains an intracellular Na+ concentration that is 10-12 times lower than the extracellular concentration. The cells then utilize this transmembrane Na+ concentration gradient as a driving force to produce electrical signals, sometimes in the form of action potentials.
Atsuo, Nishino, Yasushi, Okamura
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pH Modulation of Voltage-Gated Sodium Channels

2018
Changes in blood and tissue pH accompany physiological and pathophysiological conditions including exercise, cardiac ischemia, ischemic stroke, and cocaine ingestion. These conditions are known to trigger the symptoms of electrical diseases in patients carrying sodium channel mutations.
Colin H, Peters, Mohammad-Reza, Ghovanloo, Cynthia, Gershome, Peter C, Ruben   +3 more
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Voltage gated sodium channels

RCSB Protein Data Bank, 2020
Tomas Koltai, Stephan J. Reshkin, Salvador Harguindey   +2 more
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Toxins That Affect Voltage-Gated Sodium Channels

2017
Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years of evolutions.
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A tamoxifen receptor within a voltage-gated sodium channel

Molecular Cell, 2021
David Hollingworth, Paul Decaen, B A Wallace   +2 more
exaly  

Voltage-Gated Sodium Channels

2023
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